HOWARD UNIVERSITY GENERAL CLINICAL RESEARCH CENTER

霍华德大学普通临床研究中心

• 批准号: 8167000
• 负责人: William Robert Taylor
• 金额: --
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167000
• 关键词: African American; Anxiety; Caring; Clinical; Clinical Research; Communities; Computer Retrieval of Information on Scientific Projects Database; Exposure to; Funding; Genetic Polymorphism; Grant; Hospitals; Institution; Link; Major Depressive Disorder; Mental Depression; Mental disorders; Patients; Post-Traumatic Stress Disorders; Prevalence; Research; Research Personnel; Resources; Risk; Source; Survivors; Trauma; United States National Institutes of Health; Universities; base; coping; experience

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Description (provided by applicant): Specific Aims: (1) To determine the prevalence of exposure to specific types of traumatic experiences among patients receiving care in a hospital based, primary clinical setting in a predominantly African American community. (2) To determine the prevalence of posttraumatic stress disorder (PTSD) and related psychiatric disorders such as major depression among those who have experienced significant trauma. (3) To identify risk and protective factors that influence which trauma survivors develop posttraumatic stress disorder and/or depression and those who do not. We will specifically evaluate: a. coping strategies and determine whether there are differences in coping styles for trauma survivors that develop PTSD versus those survivors that do not develop PTSD; b. genetic polymorphisms that have been linked to anxiety and depression and determine their associations with the presence or absence of PTSD among those with exposure to severe trauma.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 描述（申请人提供）： 具体目标： (1)确定在以非裔美国人为主的社区中，在以医院为基础的主要临床环境中接受护理的患者中暴露于特定类型创伤经历的患病率。 (2)确定创伤后应激障碍（PTSD）和相关精神疾病（如重度抑郁症）在经历过严重创伤的人群中的患病率。 (3)确定影响创伤幸存者发展创伤后应激障碍和/或抑郁的风险和保护因素。我们将具体评估：a。应对策略并确定发展PTSD的创伤幸存者与未发展PTSD的那些幸存者的应对方式是否存在差异; B.基因多态性与焦虑和抑郁有关，并决定了它们与暴露于严重创伤的人中PTSD的存在或不存在的关系。