HOWARD UNIVERSITY GENERAL CLINICAL RESEARCH CENTER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 描述(由申请人提供)： 具体目标： (1)确定在以非裔美国人为主的社区中，在以医院为基础的初级临床环境中接受护理的患者中暴露于特定类型创伤经历的流行率。 (2)确定创伤后应激障碍(PTSD)和相关精神障碍(如重度抑郁症)在经历过重大创伤的人中的患病率。 (3)确定影响创伤幸存者发生创伤后应激障碍和/或抑郁的风险和保护因素，以及没有发生创伤后应激障碍和/或抑郁的人。我们将具体评估：a.应对策略，并确定患有创伤后应激障碍的幸存者与未患创伤后应激障碍的幸存者在应对方式上是否存在差异；b.与焦虑和抑郁有关的基因多态，并确定它们与严重创伤暴露者中是否存在创伤后应激障碍的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Description (provided by applicant): Specific Aims: (1) To determine the prevalence of exposure to specific types of traumatic experiences among patients receiving care in a hospital based, primary clinical setting in a predominantly African American community. (2) To determine the prevalence of posttraumatic stress disorder (PTSD) and related psychiatric disorders such as major depression among those who have experienced significant trauma. (3) To identify risk and protective factors that influence which trauma survivors develop posttraumatic stress disorder and/or depression and those who do not. We will specifically evaluate: a. coping strategies and determine whether there are differences in coping styles for trauma survivors that develop PTSD versus those survivors that do not develop PTSD; b. genetic polymorphisms that have been linked to anxiety and depression and determine their associations with the presence or absence of PTSD among those with exposure to severe trauma.