Biology, Biomechanics and Atherosclerosis

生物学、生物力学和动脉粥样硬化

• 批准号: 7822529
• 负责人: William Robert Taylor
• 金额: $ 1.86万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7822529
• 关键词: Abdominal Aortic Aneurysm; Age; American; Aneurysm; Area; Atherosclerosis; Biological; Biology; Biomechanics; Biomedical Engineering; Blood Vessels; Cathepsins; Cells; Clinical; Collagen; Computer Simulation; Coronary Arteriosclerosis; Cysteine Protease; Data; Development; Diagnosis; Disease; Elastin; Employee Strikes; Engineering; Extravasation; Family; Funding; Goals; Hand; Human; Human Resources; Hypertension; In Vitro; Incidence; Incidence Study; Inflammatory; Knowledge; Laboratories; Length; Longevity; Mechanics; Mediating; Modeling; Molecular; Morbidity - disease rate; Operative Surgical Procedures; Papain; Pathway interactions; Peripheral Vascular Diseases; Play; Population; Process; Property; Prosthesis; Protein Family; Protein-Lysine 6-Oxidase; Proteins; Published Comment; Regulation; Research; Research Personnel; Risk Factors; Role; Rupture; Ruptured Aneurysm; Series; Staging; Stress; Testing; Tissues; United States; abdominal aorta; base; cardiovascular risk factor; computerized tools; crosslink; effective therapy; improved; in vivo; infancy; insight; macrophage; member; men; molecular imaging; mortality; novel; oxidized lipid; response; shear stress; syndecan

DESCRIPTION (provided by applicant): This proposal is for continued support of our Bioengineering Research Partnership entitled Biology, Biomechanics and Atherosclerosis. Over the first 4 years of our BRP funding, our group has focused on obtaining a better understanding of the basic mechanism of atherosclerosis with a particular focus on the interrelationships between biomechanical forces and atherosclerosis. Our initial efforts have been broad in scope incorporating the expertise of engineers, biologists and clinicians from an expansive range of clinical and academic areas. In this, our request for continued support, we have elected to focus our efforts on a single atherosclerotic disease entity, abdominal aortic aneurysms (AAA). We have taken this approach based on several factors including the importance of the clinical problem, the development of extensive, relevant preliminary data by members of the BRP and the potential benefit of having a greater focus for the members of the BRP. The overall goal of this BRP is to gain a better understanding of the biology and biomechanics of AAA formation with the overall goal of gaining new insights into the underlying mechanisms of AAA development. This project is support my novel data from the members of this BRP that implicate additional protein families in the maladaptive remodeling of the aortic wall that occurs during AAA formation. This proposal will focus on developing aneurysms at the earliest stages of remodeling so as to study the most biologically relevant aspects of AAA formation.

描述(由申请人提供)：本提案是为了继续支持我们的生物工程研究伙伴关系，名为生物学、生物力学和动脉粥样硬化。在我们BRP资助的头4年里，我们的团队专注于更好地了解动脉粥样硬化的基本机制，特别是生物力学力量和动脉粥样硬化之间的相互关系。我们最初的努力范围很广，融合了来自广泛临床和学术领域的工程师、生物学家和临床医生的专业知识。在这方面，我们请求继续支持，我们选择将我们的努力集中在单一的动脉粥样硬化性疾病实体-腹主动脉瘤(AAA)上。我们采取这一方法是基于几个因素，包括临床问题的重要性，BRP成员广泛相关的初步数据的发展，以及BRP成员更多关注的潜在好处。 这项BRP的总体目标是更好地了解AAA形成的生物学和生物力学，总的目标是对AAA发展的潜在机制获得新的见解。这个项目支持我来自BRP成员的新数据，这些数据表明在AAA形成过程中发生的主动脉壁不适应性重构中涉及到额外的蛋白质家族。这项建议将侧重于在重建的早期阶段发展动脉瘤，以研究AAA形成中最具生物学意义的方面。