MALT LIQUOR

麦芽酒

• 批准号: 7607808
• 负责人: William Robert Taylor
• 金额: $ 0.16万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607808
• 关键词: Acute; Address; Advertising; African American; Age; Alcohol abuse; Alcohol dependence; Alcoholism; Alcohols; Beer; Behavioral; Beverages; Biological; Characteristics; Clinical; Computer Retrieval of Information on Scientific Projects Database; Consumption; Cross-Over Studies; Data; Dependence; Development; Drug Kinetics; Economics; Environmental Risk Factor; Frequencies; Funding; Genotype; Goals; Grant; Ingestion; Institution; Malt Grain; Medical; Modeling; National Institute on Alcohol Abuse and Alcoholism; Oral; Outcome; Pattern; Phenotype; Population; Population Study; Procedures; Recruitment Activity; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Resources; Site; Socioeconomic Status; Source; Spirituality; Testing; Tobacco use; Training; United States National Institutes of Health; Woman; absorption; aged; alcohol content; alcohol research; base; clinical phenotype; cohort; design; distilled alcoholic beverage; drinking; experience; instrument; internal control; men; preference; problem drinker; psychosocial; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Alcoholism produces social, environmental and medical outcomes in African Americans with devastating economic consequences. The overall goal of the proposed research is to determine the relationship between high alcohol content malt beverages and the contibution such beverages make to increased consumption patterns among urban African Americans, a study population previously underrespresented in most research activities. The significance of malt liquor as a contributing specific factor in alcoholism or alcohol abuse has not been studied to a significant degree in any population. This study addresses 3 important questions: How is the consumption of malt liquor associated with the onset of drinking, psychosocial phenotypes and the development of alcohol problems, including alcohol abuse and dependence? Are there differences in malt liquor consumption patterns related to age and socioeconomic status? Are there pharmacokinetic differences in alcohol absorption and/or elimination following oral ingestion of malt liquors? Two specific aims are proposed: (1) Using a population-based study design, identify specific user characteristics related to alcohol beverage preferences including use frequency and consumption levels, economic, psychosocial, behavioral and environmental factors, and ADH genotype among a cohort of 300 urban African American men and women with specific emphasis on the relationship of malt alcoholic preference to these factors. The contribution of factors such as advertising, tobacco use and spirituality in the development of malt liquor preference will also be explored. From this data, a clinical phenotype of an active dependent and nondependent user of these beverages will be identified, and (2) Using a cross-over study design, sixty healthy non-alcohol dependent African American men and women, aged 21-25 will be recruited to determine and quantify biological differences in alcohol pharmacokinetics following the acute oral consumption of regular beer and/or malt liquors of varying alcohol concentrations, using an oral challenge model containing internal controls designed to reduce subject variability. The rationale for the proposed study is strengthened by the availability of numerous well developed subject recruitment sites, and existing training/experience in the administration of similar test instruments and clinical procedures, availability of a NIH-funded GCRC with the ability to support the oral alcohol challenge studies, and the administrative and scientific infrastructure of a NIAAA Collaborative Alcohol Research Center. From these studies, our understanding of the critical factors influencing the preference for malt liquor will be identified and the biological basis for the presumed differences in alcohol pharmacokinetics will be described.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 酒精中毒会在经济后果造成毁灭性的非洲裔美国人中产生社会，环境和医疗结果。 拟议的研究的总体目标是确定高酒精含量麦芽饮料的关系和这种饮料对增加城市非洲裔美国人的消费模式所产生的contib饮之间的关系，这项研究人群以前在大多数研究活动中都不足。 在任何人群中，麦芽酒作为酗酒或酗酒的特定因素的重要性尚未得到很大的研究。 这项研究解决了3个重要问题：麦芽酒的消费与饮酒，社会心理表型的发作以及酒精问题（包括酒精滥用和依赖）的发展如何相关？ 与年龄和社会经济地位有关的麦芽饮用液体消费模式是否存在差异？ 口服麦芽酒后，是否存在药代动力学差异？ 提出了两个具体目的：（1）使用基于人群的研究设计，确定与酒精饮料偏好相关的特定用户特征，包括使用频率和消费水平，经济，社会心理，行为和环境因素，以及在300名城市非裔美国人男性和女性中，在同类中，具有特定强调的麦芽酒精宠物与这些因素的关系。 还将探讨广告，烟草使用和灵性等因素在麦芽酒偏好开发中的贡献。 从这些数据中，将确定对这些饮料的积极依赖和非依赖性用户的临床表型，（2）使用跨界研究设计，六十个健康的非酒精依赖的非酒精依赖的非酒精男性和女性，将招募21-25岁的年龄在21-25岁之间，以确定和量化普通啤酒饮酒剂和MAL啤酒的生物学差异，或量化的生物学差异，或者是在急性啤酒中的毒品或MAL TOURCAINT ORAL TORMITISS ORATITS ORALTISS ORALTISS ORALTISS ORITIAS或MAL TORMITIST INFORATION ORATISITS POLITIAS ORITIST INFARES ORITIASS PROTICTICS招募来招募。包含旨在降低主题可变性的内部控制的模型。 拟议研究的基本原理通过众多发达的受试者招聘站点的可用性以及在管理类似测试工具和临床程序中的现有培训/经验，提供NIH资助的GCRC，具有支持口腔酒精挑战研究的能力以及NIAAA协作性酒精研究中心的行政和科学基础设施的能力。 从这些研究中，将确定我们对影响麦芽酒偏好的关键因素的理解，并将描述酒精药代动力学差异的生物学基础。