Neuronal Basis of Conditioned Defeat

条件性失败的神经元基础

基本信息

  • 批准号:
    6538370
  • 负责人:
  • 金额:
    $ 0.9万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-05-01 至
  • 项目状态:
    未结题

项目摘要

Many species experience social stressors during their lifetimes. This is especially true for humans, whose overwhelming source of conflict and stress is social in nature. A large body of evidence suggests that exposure to traumatic events or persistent high levels of stress are linked to the development and expression of a number of stress-related disorders (i.e. PTSD, depression, anxiety disorders). Animal models of stress-related disorders have provided important information about the neurobiological basis of many psychopathologies. Very few models, however, have examined these disorders in a biologically relevant paradigm. Conditioned defeat in Syrian hamsters provides an ideal model for studying the neurobiological basis of stress-related disorders in an ecologically relevant context. The goal of the current proposal is to explore the neuroanatomical and neurochemical basis of conditioned defeat by using site-specific microinjections into specific brain nuclei. The present proposal will test the hypothesis that the brain areas and neurochemicals that are involved in fear, anxiety and behavioral responses to stressors, in general, are also critical in the acquisition and expression of conditioned defeat. The results of the current proposal will provide important insight into the underlying physiological mechanisms of conditioned defeat. Additionally, these data will contribute to our knowledge about the neurobiological basis of human stress-related disorders.
许多物种在其一生中都会经历社会压力。这对人类来说尤其如此,他们的冲突和压力的压倒性来源是社会性的。大量证据表明,暴露于创伤性事件或持续的高水平压力与许多与压力有关的疾病(即创伤后应激障碍,抑郁症,焦虑症)的发展和表达有关。应激相关疾病的动物模型为许多精神病理学的神经生物学基础提供了重要信息。然而,很少有模型在生物学相关的范式中研究这些疾病。条件性失败在叙利亚仓鼠提供了一个理想的模型,研究神经生物学基础的压力相关的障碍,在生态相关的背景下。目前的建议的目标是探索神经解剖学和神经化学基础的条件性失败,通过使用特定部位的显微注射到特定的脑核团。本提案将检验这样的假设:一般来说,参与恐惧、焦虑和对压力源的行为反应的大脑区域和神经化学物质在条件性失败的获得和表达中也至关重要。目前的建议的结果将提供重要的洞察条件失败的潜在生理机制。此外,这些数据将有助于我们了解人类压力相关疾病的神经生物学基础。

项目成果

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Aaron M Jasnow其他文献

Aaron M Jasnow的其他文献

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{{ truncateString('Aaron M Jasnow', 18)}}的其他基金

Cholinergic regulation of amygdalar circuits in emotional memory
情绪记忆中杏仁核回路的胆碱能调节
  • 批准号:
    10737193
  • 财政年份:
    2023
  • 资助金额:
    $ 0.9万
  • 项目类别:
Neuroendocrine mechanisms of emotional behavior
情绪行为的神经内分泌机制
  • 批准号:
    6835423
  • 财政年份:
    2004
  • 资助金额:
    $ 0.9万
  • 项目类别:
Neuronal Basis of Conditioned Defeat
条件性失败的神经元基础
  • 批准号:
    6340396
  • 财政年份:
    2001
  • 资助金额:
    $ 0.9万
  • 项目类别:

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