Parietal and Temporal Circuits in Cognition

描述：(申请人提供) 该项目的目标是定位大脑中的认知功能。 大脑皮层，确定相关的解剖路径并揭示 在次级靶结构上局部的大脑去激活以识别 构成特定认知任务的神经回路。这项调查 将集中在两个大脑皮层区域，这两个区域构成了不同的认知 功能：顶叶中上丘(MS)皮质， 从属于对空间和运动的认知，以及腹后部 颞叶上丘(VPS)皮质，它辅助学习和 对形式和图案的识别。该项目将检验多发性硬化症 而VPS皮层通过差异性产生特定的功能贡献 在执行期间对主要和次要目标结构的影响 运动和形体辨别任务。这将通过以下方式进行测试：1)分离 使用可逆冷却停用的形状和运动功能，2) 成功或失活期间降温失活对神经的影响 使用实验的2(任务)x 3(区域)矩阵影响任务绩效 2-脱氧葡萄糖作为准确的神经标志物的条件和应用 活动，以及3)将解剖回路的组织与 可逆失活的功能影响。因此，该项目将把 大脑网络结构和活动水平与专业认知 功能。

DESCRIPTION: (provided by applicant) The goal of the project is to localize cognitive functions in the cerebral cortex, identify associated anatomical pathways and reveal the impact of localized, cerebral deactivations on secondary target structures to identify the neural circuits that underlie specific cognitive tasks. The investigation will center on two cerebral cortical regions which underlie distinct cognitive functions: Middle suprasylvian (MS) cortex in the parietal region, which subserves cognition of space and movement, and the ventral posterior suprasylvian (vPS) cortex in the temporal region, which subserves learning and recognition of forms and patterns. The project will test the hypothesis that MS and vPS cortices make specific functional contributions through a differential impact on primary and secondary target structures during performance of movement and form discrimination tasks. This will be tested by: 1) dissociating form and movement functions using reversible cooling deactivation, 2) dissociating the neural impact of cooling deactivation during successful or impaired task performance using a 2 (task) x 3 (region) matrix of experimental conditions and employing 2-deoxyglucose as an accurate marker of neural activity, and 3) relating the organization of anatomical circuits to the functional impacts of reversible deactivation. Thus, the project will link cerebral network architecture and activity levels to specialized cognitive functions.