Parietal and Temporal Circuits in Cognition

描述：（申请人提供） 该项目的目标是定位大脑中的认知功能， 皮质，识别相关的解剖通路，并揭示 在二级目标结构上的局部大脑失活， 特定认知任务的神经回路。调查 将集中在两个大脑皮层区域，这两个区域是不同认知功能的基础。 功能：顶叶区域的中上裂（MS）皮层， 有助于空间和运动的认知， 颞叶上（vPS）皮层，它有助于学习， 形式和模式的识别。该项目将测试MS 和vPS皮质通过差异化的 在执行过程中对主要和次要目标结构的影响 运动和形式识别任务。这将通过以下方式进行测试：1）分离 使用可逆冷却失活的形式和运动功能，2） 分离在成功或失败期间冷却失活的神经影响， 使用2（任务）× 3（区域）的实验矩阵， 条件和使用2-脱氧葡萄糖作为神经细胞的准确标记物， 活动，以及3）将解剖电路的组织与 可逆失活的功能影响。因此，该项目将连接 大脑网络结构和活动水平的专门认知 功能协调发展的

DESCRIPTION: (provided by applicant) The goal of the project is to localize cognitive functions in the cerebral cortex, identify associated anatomical pathways and reveal the impact of localized, cerebral deactivations on secondary target structures to identify the neural circuits that underlie specific cognitive tasks. The investigation will center on two cerebral cortical regions which underlie distinct cognitive functions: Middle suprasylvian (MS) cortex in the parietal region, which subserves cognition of space and movement, and the ventral posterior suprasylvian (vPS) cortex in the temporal region, which subserves learning and recognition of forms and patterns. The project will test the hypothesis that MS and vPS cortices make specific functional contributions through a differential impact on primary and secondary target structures during performance of movement and form discrimination tasks. This will be tested by: 1) dissociating form and movement functions using reversible cooling deactivation, 2) dissociating the neural impact of cooling deactivation during successful or impaired task performance using a 2 (task) x 3 (region) matrix of experimental conditions and employing 2-deoxyglucose as an accurate marker of neural activity, and 3) relating the organization of anatomical circuits to the functional impacts of reversible deactivation. Thus, the project will link cerebral network architecture and activity levels to specialized cognitive functions.