Parietal and Temporal Circuits in Cognition

认知中的顶叶和颞叶回路

• 批准号: 6622312
• 负责人: RICHARD Jarrett RUSHMORE
• 金额: $ 2.67万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6622312
• 关键词: behavioral /social science research tag; brain mapping; cats; cognition; deoxyglucose; form /pattern perception; histochemistry /cytochemistry; learning; motion perception; neuroanatomy; parietal lobe /cortex; predoctoral investigator; psychological tests; radionuclide imaging /scanning; radiotracer; sensory discrimination; space perception; temporal lobe /cortex

DESCRIPTION: (provided by applicant) The goal of the project is to localize cognitive functions in the cerebral cortex, identify associated anatomical pathways and reveal the impact of localized, cerebral deactivations on secondary target structures to identify the neural circuits that underlie specific cognitive tasks. The investigation will center on two cerebral cortical regions which underlie distinct cognitive functions: Middle suprasylvian (MS) cortex in the parietal region, which subserves cognition of space and movement, and the ventral posterior suprasylvian (vPS) cortex in the temporal region, which subserves learning and recognition of forms and patterns. The project will test the hypothesis that MS and vPS cortices make specific functional contributions through a differential impact on primary and secondary target structures during performance of movement and form discrimination tasks. This will be tested by: 1) dissociating form and movement functions using reversible cooling deactivation, 2) dissociating the neural impact of cooling deactivation during successful or impaired task performance using a 2 (task) x 3 (region) matrix of experimental conditions and employing 2-deoxyglucose as an accurate marker of neural activity, and 3) relating the organization of anatomical circuits to the functional impacts of reversible deactivation. Thus, the project will link cerebral network architecture and activity levels to specialized cognitive functions.

描述：（由申请人提供） 该项目的目标是定位大脑中的认知功能 皮层，识别相关的解剖通路并揭示其影响 对次要目标结构进行局部脑失活以识别 特定认知任务背后的神经回路。调查情况 将以两个大脑皮层区域为中心，这两个区域是不同认知的基础 功能： 顶叶区中侧裂上皮层 (MS)， 促进空间和运动的认知，以及腹侧后部 颞区的外侧裂上皮层 (vPS)，有助于学习和 对形式和模式的识别。该项目将检验 MS 的假设 vPS 皮质通过差异做出特定的功能贡献 执行期间对主要和次要目标结构的影响 运动和形式辨别任务。这将通过以下方式进行测试：1）解离 使用可逆冷却停用的形式和运动功能，2) 在成功或失败期间分离冷却失活的神经影响 使用 2（任务）x 3（区域）实验矩阵削弱任务性能 条件并采用 2-脱氧葡萄糖作为神经元的准确标记 活动，以及3）将解剖回路的组织与 可逆失活的功能影响。因此，该项目将链接 大脑网络结构和活动水平到专业认知 功能。