Portable Non-Invasive Acoustic Identification of Stroke

描述（由申请人提供）：Active Signal Technologies与马里兰大学医学中心的脑攻击团队合作，提出改进和测试一种新型便携式、非侵入性系统，该系统将能够快速识别中风。每年大约有75万人中风，其中80%以上是缺血性中风。然而，只有1%的患者接受了TPA等药物治疗，如果在发病3小时内服用，TPA可以溶解血栓并促进良好的结果。这一严重的健康和经济问题的众多原因之一是无法迅速区分缺血性和出血性中风，从而无法进行干预。该设备是一种小型的非侵入性系统，可以测量大脑的声学特征，并将其与患者的动脉波形进行比较。Active Signal将添加代码来计算在第一阶段确定的信号特征，以指示患者的中风状况，研究小组将对200名患者进行临床测试，以确定第一阶段确定的中风识别假设。该系统将小型化，以便EMS单位在受伤现场使用。这将大大增加接受时效性治疗的缺血性中风患者的百分比，减少残疾和医疗费用。

DESCRIPTION (provided by applicant): Active Signal Technologies, in partnership with the Brain Attack Team of the University of Maryland Medical Center, proposes to refine and test a novel portable, non-invasive system that will enable rapid identification of stroke. Approximately 750,000 people suffer a stroke each year and over 80% of these are ischemic. Yet only 1% of this number receives medical treatment such as TPA that is known to dissolve clots and promote favorable outcome if administered within 3 hours of onset. Among the many causes of this serious health and ultimately economic problem is the inability to rapidly differentiate ischemic from hemorrhagic strokes to allow intervention. The device is a small non-invasive system that measures the acoustic signature of the brain and compares it with the patient's arterial waveform. Active Signal will add code to calculate those signal features identified in Phase I as indicative of the patient's stroke condition, and the team will clinically test on 200 patients the hypotheses for stroke identification determined in Phase I. The system will be miniaturized for EMS units to use at the scene of injury. This would significantly increase the percentage of ischemic stroke patients who would receive time-sensitive therapies, reducing disability and medical costs.