Electrochemical Flow Reactors in High Value Chemical Manufacturing

研究背景：在过去的20年里，电化学在合成有机化学方法方面取得了重大进展。它允许化学家在不使用昂贵且通常有毒的金属催化剂的情况下进行困难的化学反应。尽管如此，标准化的反应器和技术仍然是阻碍这些反应在合成过程中更广泛开发和应用的主要障碍。目的和目标：在本项目中，标准化和开放式电化学流动反应器（EFR）将被开发用于有机反应。一旦建成和验证，这些反应器将用于开发一系列具有重要合成意义的三种新型反应：（i）C-H活化/胺化，（ii）催化Wittig反应，（iii）Ni（III）催化偶联反应。潜在应用和效益：该项目提供以下效益：（i）使技术能够促进在更广泛的学术界和工业界开发和采用合成科学中的电化学反应;（ii）更可持续的工艺，产品纯化更简单，废物更少，更容易扩大规模;（iii）重要的新反应，将对合成技术产生重大影响。研究领域：流动化学、电化学资格要求：有机化学博士学位

Context of research: Electrochemistry has made substantial advances in synthetic organic chemistry methods over the past 20 years. It has allowed chemists to run difficult chemical reactions without the use of expensive, and often toxic, metal catalysts. Despite these, standardised reactors and techniques are still the major obstacles preventing wider development and application of these reactions in synthetic processes.Aims and objectives: In this project, standardised and open-access electrochemical flow reactors (EFRs) will be developed for application in organic reactions. Once built and validated, the reactors will be used to develop a series of three novel reactions with significant synthetic importance: (i) C-H activation/amination, (ii) catalytic Wittig reaction, and (iii) Ni(III) catalysed coupling reaction.Potential applications and benefits: The project delivers the following benefits: (i) enabling technology to facilitate development and adoption of electrochemical reaction in synthetic science in wider academia and industry; (ii) more sustainable processes with simpler product purification, less waste, and easier to scale-up; (iii) important novel reactions which will have significant impact in synthetic technology. Research areas: Flow chemistry, electrochemistryQualification to be attained: PhD degree in Organic Chemistry