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Electrochemical Flow Reactors in High Value Chemical Manufacturing

高价值化学品制造中的电化学流动反应器

基本信息

批准号：
2090544
负责人：
金额：
--
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2017
资助国家：
英国
起止时间：
2017 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2090544
关键词：
Electrochemical Flow Reactors Value Chemical

项目摘要

Context of research: Electrochemistry has made substantial advances in synthetic organic chemistry methods over the past 20 years. It has allowed chemists to run difficult chemical reactions without the use of expensive, and often toxic, metal catalysts. Despite these, standardised reactors and techniques are still the major obstacles preventing wider development and application of these reactions in synthetic processes.Aims and objectives: In this project, standardised and open-access electrochemical flow reactors (EFRs) will be developed for application in organic reactions. Once built and validated, the reactors will be used to develop a series of three novel reactions with significant synthetic importance: (i) C-H activation/amination, (ii) catalytic Wittig reaction, and (iii) Ni(III) catalysed coupling reaction.Potential applications and benefits: The project delivers the following benefits: (i) enabling technology to facilitate development and adoption of electrochemical reaction in synthetic science in wider academia and industry; (ii) more sustainable processes with simpler product purification, less waste, and easier to scale-up; (iii) important novel reactions which will have significant impact in synthetic technology. Research areas: Flow chemistry, electrochemistryQualification to be attained: PhD degree in Organic Chemistry

研究背景：在过去的20年里，电化学在合成有机化学方法方面取得了实质性的进展。它使化学家能够在不使用昂贵且通常有毒的金属催化剂的情况下进行复杂的化学反应。尽管如此，标准化的反应器和技术仍然是阻碍这些反应在合成过程中更广泛发展和应用的主要障碍。目的和目标：在这个项目中，标准化和开放式电化学流动反应器（EFRs）将被开发用于有机反应。一旦建成并验证，反应器将用于开发一系列具有重要合成意义的三种新型反应：(i) C-H活化/胺化反应，（ii）催化Wittig反应，以及（iii） Ni（iii）催化偶联反应。潜在的应用和好处：该项目带来以下好处：(i)使技术能够促进合成科学中电化学反应的发展和采用，并在更广泛的学术界和工业界得到应用；（ii）更可持续的工艺，产品净化更简单，浪费更少，更容易扩大规模；（iii）对合成技术有重大影响的重要的新反应。研究方向：流动化学，电化学。资格要求：有机化学博士学位