TRAINING GRANT IN NEUROMUSCULAR DISEASES AND BIOLOGY

神经肌肉疾病和生物学培训补助金

• 批准号: 6530979
• 负责人: DANIEL B DRACHMAN
• 金额: $ 3.73万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6530979
• 关键词: TRAINING; GRANT; NEUROMUSCULAR; DISEASES; BIOLOGY

It has been estimated that more than one third of patients with neurological disorders with problems affecting the neuromuscular system. Striking progress has been made in understanding many of these diseases, and in the effective application of the new knowledge to treatment. This progress has been made possible by the intimate interaction of basic and clinical scientific approaches. At the same time, the analysis of human neuromuscular diseases has contributed to the understanding of the basic biology of nerves, muscles, and nerve-muscle interactions. The goal of this proposal is to foster the training of both clinical and basic scientists in the areas of neuromuscular biology and disease, so as to encourage even more intense interactions between these approaches. The faculty, laboratories and programs involved are well-established, highly interactive, and productive. The areas of research focus on the neuromuscular system, but entail a wide range of approaches and methodologies. Representative disease-oriented areas include: amyotrophic lateral sclerosis; spinal muscular atrophy; peripheral neuropathies; myasthenia gravis; muscular dystrophies; and autoimmune myopathies. A wide variety of research approaches are used, and basic methods include those of molecular biology, immunology, morphology, pharmacology, cell culture, and electrophysiology. Clinical material and clinical trials serve as lynch pins of the program. The trainees will be both clinicians and basic scientists with doctoral degrees, (many MD/PhDs) whose goals are to perform significant research in the fields of neuromuscular diseases and biology; Support for four postdoctoral fellows is requested is requested. We will stress the recruitment of minority applicants. The training program involves intensive laboratory research, and postdoctoral fellows are encourage to audit relevant courses and to participate in the well-organized programs on seminars and conferences. Special emphasis is placed on the integration of disease-oriented and basic science research approaches. The facilities available are those of well-equipped ongoing productive laboratories, in the rich environment of the John Hopkins Medical Institutions.

据估计，患有影响神经肌肉系统的问题的神经系统疾病患者中有超过三分之一。在理解许多这些疾病以及新知识将新知识应用于治疗方面，已经取得了惊人的进步。通过基本和临床科学方法的紧密相互作用，已经实现了这一进展。同时，人类神经肌肉疾病的分析有助于理解神经，肌肉和神经肌肉相互作用的基本生物学。该提案的目的是培养神经肌肉生物学和疾病领域中临床和基础科学家的培训，以鼓励这些方法之间更加激烈的相互作用。所涉及的教职员工，实验室和计划是完善的，高度互动和富有成效的。研究领域的重点是神经肌肉系统，但需要多种方法和方法。代表性的面向疾病的区域包括：肌萎缩性侧性硬化症；脊柱肌肉萎缩；周围神经病；肌无力肌肉营养不良；和自身免疫性肌病。使用了多种研究方法，基本方法包括分子生物学，免疫学，形态，药理学，细胞培养和电生理学的方法。临床材料和临床试验是该计划的林奇引脚。学员将是具有博士学位的临床医生和基础科学家（许多MD/PHD），其目标是在神经肌肉疾病和生物学领域进行大量研究；请求支持四个博士后研究员。我们将强调少数民族申请人的招募。该培训计划涉及密集的实验室研究，并鼓励博士后研究员审核相关课程，并参加有关研讨会和会议组织良好的计划。特别强调了面向疾病和基础科学研究方法的整合。在约翰·霍普金斯医疗机构的丰富环境中，可用的设施是设施良好的生产实验室。