Post-transcriptional Control of Gene Expression

描述（由申请人提供）： 该提案要求为美国联邦政府提供部分资金， 实验生物学学会（FASEB）会议题为“后- 基因表达的转录控制：mRNA衰变的效应子”。 这 会议将于2002年7月6日至11日在亚利桑那州图森市举行。 mRNA衰变作用 在决定基因表达水平方面起主要作用。 的 微阵列的出现已经牢固地建立了两个关键概念：（1） 不同mRNA的半衰期不同， 功能，和（2）个别mRNA的半衰期不同， 与mRNA功能相关的代谢条件。 因此了解 mRNA降解的机制对于理解 基因受到调控。 这种理解变得更加有价值 考虑到可以使用mRNA降解的操纵的许多情况 作为疾病治疗的手段。 参与者将包括那些研究mRNA的人 在原核生物和真核生物的衰变，使这次会议从所有独特的 另一些人则为所有研究mRNA衰变的人提供了一个交换的机会， 想法. 有36位杰出的特邀演讲者，其中10位是妇女， 其中7人是助理教授级的杰出科学家， 会议的目标是聚集大约120人， 一种会议环境，允许信息通过基调自由流动 演讲、平台展示、海报展示、圆桌讨论 和讲习班。 将创建摘要小册子以提供摘要 和所有与会者的邮寄/电子邮件地址，作为补充方式， 交换信息 所涵盖的主题包括： 了解原核生物和真核生物的多功能核酸酶， mRNA定位和mRNA翻译影响mRNA半衰期，顺式作用 序列和mRNA半衰期的反式作用效应物，以及RNA作为 药物设计的工具和目标。

DESCRIPTION (provided by applicant): This proposal requests partial funding for the Federation of American Societies of Experimental Biology (FASEB) conference entitled "Post- Transcriptional Control of Gene Expression: Effectors of mRNA Decay". This conference will be held July 6-11, 2002 in Tucson, Arizona. MRNA decay plays a major role in determining the level at which genes are expressed. The advent of microarrays has firmly established two critical concepts: (1) the half-lives of different mRNAs differ in ways that correlate with mRNA function, and (2) the half-lives of individual mRNAs vary in response to metabolic conditions that relate to mRNA function. Therefore, understanding the mechanisms of mRNA degradation becomes very important to understanding how genes are regulated. This understanding becomes all the more valuable considering the many cases where manipulation of mRNA degradation can be used as means of disease therapy. Participants will include those studying mRNA decay in both prokaryotes and eukaryotes, making this meeting unique from all others in offering all individuals who study mRNA decay a chance to exchange ideas. There are 36 distinguished invited speakers, 10 of whom are women and 7 of whom are outstanding scientists at the level of Assistant Professor or less. The goal of the meeting is to gather approximately 120 individuals in a conference environment that allows the free flow in information via a keynote talk, platform presentations, poster presentations, round-table discussions and workshops. An Abstract Booklet will be created to provide the abstracts and mailing/email addresses of all participants as a supplementary way to exchange information. Topics to be covered include the recent advances in understanding multifunctional nucleases of prokaryotes and eukaryotes, how mRNA localization and mRNA translation affect mRNA half-lives, cis-acting sequences and trans-acting effectors of mRNA half-lives, and the use of RNA as a tool and target for drug design.