Post-transcriptional Control of Gene Expression

描述(由申请人提供)： 这项提案要求为美国联邦政府提供部分资金 美国实验生物学学会(FASE B)会议题为“后 基因表达的转录控制：信使核糖核酸衰变的效应“。 会议将于2002年7月6日至11日在亚利桑那州图森市举行。信使核糖核酸衰变 在决定基因表达水平方面起着重要作用。这个 微阵列的出现牢固地确立了两个关键概念：(1) 不同信使核糖核酸的半衰期与信使核糖核酸的相关方式不同 功能，以及(2)单个mRNAs的半衰期随 与信使核糖核酸功能相关的代谢条件。因此，理解 信使核糖核酸降解的机制对于理解 基因是受调控的。这种理解变得更加有价值。 考虑到可以使用操纵信使核糖核酸降解的许多情况 作为疾病治疗的手段。参与者将包括研究mrna的人。 原核生物和真核生物的腐烂，使这次会议与众不同 另一项是为所有研究mRNA衰变的个人提供交换机会 想法。有36位杰出的特邀演讲者，其中10位是女性和 其中7人是助理教授或助理教授级别的杰出科学家 较少。会议的目标是将大约120个人聚集在一个 会议环境，允许通过主旨演讲自由流动信息 演讲、平台演示、海报演示、圆桌讨论 和研讨会。将制作一本摘要手册来提供摘要 以及所有参与者的邮件/电子邮件地址作为补充方式 交换信息。将涵盖的主题包括 了解原核生物和真核生物的多功能核酸酶 信使核糖核酸定位和翻译影响信使核糖核酸半衰期，顺式作用 信使核糖核酸半衰期的序列和反式作用效应物，以及RNA作为 药物设计的工具和目标。

DESCRIPTION (provided by applicant): This proposal requests partial funding for the Federation of American Societies of Experimental Biology (FASEB) conference entitled "Post- Transcriptional Control of Gene Expression: Effectors of mRNA Decay". This conference will be held July 6-11, 2002 in Tucson, Arizona. MRNA decay plays a major role in determining the level at which genes are expressed. The advent of microarrays has firmly established two critical concepts: (1) the half-lives of different mRNAs differ in ways that correlate with mRNA function, and (2) the half-lives of individual mRNAs vary in response to metabolic conditions that relate to mRNA function. Therefore, understanding the mechanisms of mRNA degradation becomes very important to understanding how genes are regulated. This understanding becomes all the more valuable considering the many cases where manipulation of mRNA degradation can be used as means of disease therapy. Participants will include those studying mRNA decay in both prokaryotes and eukaryotes, making this meeting unique from all others in offering all individuals who study mRNA decay a chance to exchange ideas. There are 36 distinguished invited speakers, 10 of whom are women and 7 of whom are outstanding scientists at the level of Assistant Professor or less. The goal of the meeting is to gather approximately 120 individuals in a conference environment that allows the free flow in information via a keynote talk, platform presentations, poster presentations, round-table discussions and workshops. An Abstract Booklet will be created to provide the abstracts and mailing/email addresses of all participants as a supplementary way to exchange information. Topics to be covered include the recent advances in understanding multifunctional nucleases of prokaryotes and eukaryotes, how mRNA localization and mRNA translation affect mRNA half-lives, cis-acting sequences and trans-acting effectors of mRNA half-lives, and the use of RNA as a tool and target for drug design.