Training in Cellular, Biochemical and Molecular Sciences

细胞、生化和分子科学培训

• 批准号: 7849807
• 负责人: Lynne E Maquat
• 金额: $ 26.24万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7849807
• 关键词: Biochemical; Molecular; Science; Training

DESCRIPTION (provided by applicant): We describe the continuation of a pre-doctoral training program in Cellular, Biochemical and Molecular Biology (http://dbb.urmc.rochester.edu/T32/index.htm) with a core of interactive investigators in RNA, DNA, and protein biochemistry. The proposed training program capitalizes on (i) initiatives that expand research and education at the University of Rochester Medical Center (URMC) and College of Arts and Sciences (CAS), and (ii) enhanced educational choices resulting from the successful reorganization of Graduate Education in Biomedical Sciences (GEBS). Students are accepted into multidisciplinary "Clusters". They experience diverse research areas in their first year through courses, faculty research presentations, and laboratory rotations. They then choose a research advisor and degree program from a wide range of opportunities. We will maintain successful T32 initiatives: 1) provide one year of financial support for 6-8 students performing interdisciplinary research; 2) promote direct interactions between students and visiting seminar speakers; 3) offer practice in critical thinking in research science; 4) provide opportunities for off-site student travel to attend meetings, take courses, and work in outside laboratories; 5) counsel female and minority students to achieve career goals; 6) foster interactions among investigators and students in the areas of RNA, DNA, and protein biochemistry through course requirements and a yearly retreat; and 7) augment effective student recruiting through training-grant educational benefits. The University is benefiting from the recent appointments of a new President and Medical Center Director. Since funding of this T32, the URMC has not only filled two new research facilities (400,000 sq. ft.) and started new programs in Genetics, Biochemistry, Structural Biology, Virology, Signaling, Immunology, Neurobiology and Stem Cells, increasing the number of PIs from 150 to about 250, but also initiated a Strategic Plan with the construction of 500,000 sq. ft. of new labs. The Strategic Plan includes creation of five Innovative Science Programs that increase the opportunities for graduate training. Within this expanding infrastructure, our T32 continues to promote interactions among labs, flexibility in the choice of research mentors, and improved graduate recruiting. PUBLIC HEALTH RELEVANCE: Research funded by this T32 pertains to cellular, biochemical and molecular biology, with a focus on the structure and function of DNA, RNA and proteins. In view of the recent appreciation that most of genomic DNA is transcribed into RNA and that many genes encode more than one protein, research supported by this T32 will lend important insight into the mechanisms of cellular maintenance, growth and differentiation.

描述(由申请人提供)：我们描述了细胞、生化和分子生物学(http://dbb.urmc.rochester.edu/T32/index.htm))博士前培训计划的继续，核心是核糖核酸、脱氧核糖核酸和蛋白质生物化学的互动研究人员。拟议的培训计划利用了(I)扩大罗切斯特大学医学中心(URMC)和艺术与科学学院(CAS)研究和教育的举措，以及(Ii)由于生物医学研究生教育(GEBS)的成功重组而增加了教育选择。学生被接纳为多学科的“集群”。他们在第一年通过课程、教师研究报告和实验室轮换来体验不同的研究领域。然后，他们从广泛的机会中选择研究顾问和学位课程。我们将保持成功的T32计划：1)为6-8名从事跨学科研究的学生提供一年的财政支持；2)促进学生与来访研讨会演讲者之间的直接互动；3)提供研究性科学中批判性思维的实践；4)为非现场学生旅行提供参加会议、参加课程和在外部实验室工作的机会；5)为女性和少数族裔学生提供咨询以实现职业目标；6)通过课程要求和年度务虚会促进研究人员和学生在RNA、DNA和蛋白质生物化学领域的互动；以及7)通过培训资助教育福利增加有效的招生。该大学受益于最近任命的一位新校长和医学中心主任。自资助T32以来，市建局不仅填满了两个新的研究设施(40万平方英尺)。英国《金融时报》)并启动了遗传学、生物化学、结构生物学、病毒学、信号学、免疫学、神经生物学和干细胞等新的项目，将PI的数量从150个增加到约250个，但也启动了一个战略计划，建设了50万平方米。英国《金融时报》新的实验室。该战略计划包括创建五个创新的科学计划，以增加研究生培训的机会。在不断扩大的基础设施中，我们的T32继续促进实验室之间的互动，灵活选择研究导师，并改善毕业生招聘。 公共卫生相关性：这项由T32资助的研究涉及细胞、生化和分子生物学，重点是DNA、RNA和蛋白质的结构和功能。鉴于最近人们认识到大多数基因组DNA转录成RNA，以及许多基因编码不止一种蛋白质，由T32支持的研究将为细胞维持、生长和分化的机制提供重要的见解。