Training in Cellular, Biochemical and Molecular Sciences

描述（由申请人提供）：我们描述了在细胞，生物化学和分子生物学（http：//dbb.urmc.rochester.edu/T32/index.htm）的博士前培训计划的延续与RNA，DNA和蛋白质生物化学的交互式研究人员的核心。拟议的培训计划利用（一）在罗切斯特医学中心（URMC）和艺术与科学学院（CAS）的大学扩大研究和教育的举措，及（ii）增强教育的选择，从生物医学科学研究生教育（GEBS）的成功重组。学生被接受到多学科的“集群”。他们在第一年通过课程，教师研究演示和实验室轮换体验不同的研究领域。然后，他们从广泛的机会中选择研究顾问和学位课程。我们将保持成功的T32举措：1）为6-8名进行跨学科研究的学生提供一年的财政支持; 2）促进学生和来访的研讨会演讲者之间的直接互动; 3）提供研究科学批判性思维的实践; 4）为场外学生旅行提供机会，参加会议，参加课程，并在外面的实验室工作; 5）辅导女性和少数民族学生实现职业目标; 6）通过课程要求和年度务虚会促进研究人员和学生在RNA，DNA和蛋白质生物化学领域的互动; 7）通过培训补助教育福利增加有效的学生招聘。该大学受益于最近任命的新校长和医疗中心主任。自从T32项目获得资助以来，URMC不仅填补了两个新的研究设施（40万平方米）。（英尺）并开始在遗传学，生物化学，结构生物学，病毒学，信号传导，免疫学，神经生物学和干细胞的新计划，增加PI的数量从150到约250，但也启动了一个战略计划，建设500，000平方米。英尺新的实验室该战略计划包括建立五个创新科学方案，增加研究生培训的机会。在这个不断扩大的基础设施，我们的T32继续促进实验室之间的互动，在研究导师的选择灵活性，并改善毕业生招聘。 公共卫生相关性：由该T32资助的研究涉及细胞，生物化学和分子生物学，重点是DNA，RNA和蛋白质的结构和功能。鉴于最近的认识，大多数基因组DNA被转录成RNA，许多基因编码一种以上的蛋白质，由这个T32支持的研究将提供重要的洞察细胞的维持，生长和分化的机制。

DESCRIPTION (provided by applicant): We describe the continuation of a pre-doctoral training program in Cellular, Biochemical and Molecular Biology (http://dbb.urmc.rochester.edu/T32/index.htm) with a core of interactive investigators in RNA, DNA, and protein biochemistry. The proposed training program capitalizes on (i) initiatives that expand research and education at the University of Rochester Medical Center (URMC) and College of Arts and Sciences (CAS), and (ii) enhanced educational choices resulting from the successful reorganization of Graduate Education in Biomedical Sciences (GEBS). Students are accepted into multidisciplinary "Clusters". They experience diverse research areas in their first year through courses, faculty research presentations, and laboratory rotations. They then choose a research advisor and degree program from a wide range of opportunities. We will maintain successful T32 initiatives: 1) provide one year of financial support for 6-8 students performing interdisciplinary research; 2) promote direct interactions between students and visiting seminar speakers; 3) offer practice in critical thinking in research science; 4) provide opportunities for off-site student travel to attend meetings, take courses, and work in outside laboratories; 5) counsel female and minority students to achieve career goals; 6) foster interactions among investigators and students in the areas of RNA, DNA, and protein biochemistry through course requirements and a yearly retreat; and 7) augment effective student recruiting through training-grant educational benefits. The University is benefiting from the recent appointments of a new President and Medical Center Director. Since funding of this T32, the URMC has not only filled two new research facilities (400,000 sq. ft.) and started new programs in Genetics, Biochemistry, Structural Biology, Virology, Signaling, Immunology, Neurobiology and Stem Cells, increasing the number of PIs from 150 to about 250, but also initiated a Strategic Plan with the construction of 500,000 sq. ft. of new labs. The Strategic Plan includes creation of five Innovative Science Programs that increase the opportunities for graduate training. Within this expanding infrastructure, our T32 continues to promote interactions among labs, flexibility in the choice of research mentors, and improved graduate recruiting. PUBLIC HEALTH RELEVANCE: Research funded by this T32 pertains to cellular, biochemical and molecular biology, with a focus on the structure and function of DNA, RNA and proteins. In view of the recent appreciation that most of genomic DNA is transcribed into RNA and that many genes encode more than one protein, research supported by this T32 will lend important insight into the mechanisms of cellular maintenance, growth and differentiation.