2010 Post-Transcriptional Gene Regulation Biology of Gordon Research Conference

描述（由申请人提供）：本提案要求对将于2010年7月18日至7月23日在罗得岛纽波特的Salve Regina大学举行的关于转录后基因调控生物学的戈登研究会议（GRC）提供部分支持。这是自2004年以来每两年举行一次的系列会议中的第四次。会议的广泛和长期目标是提高我们目前对正常和疾病状态下RNA生物合成的基本机制和调控的理解。重点是涉及mRNA的产生和代谢的转录后交易，但这延伸到转录偶联，以及涉及翻译及其控制的因子，包括tRNA和非编码（例如，微）RNA。本次会议的具体目标是召集约45位代表转录后基因调控关键领域的国际知名演讲者，共有150名与会者，为期五天。该计划将包括九个上午或晚上的会议，将广泛解决前沿问题：转录和RNA加工之间的耦合;基因组学和RNA加工信号和因子的进化（包括使用免疫沉淀法，然后使用微阵列或高通量测序，确定正常和疾病中RNA结合蛋白的靶点）; RNA剪接催化、保真度、调节和参与疾病; RNA周转，包括无义介导的mRNA衰变; RNA转运和定位;非编码RNA;翻译控制;以及RNA-蛋白质相互作用。此外，在四个下午晚些时候举行的小型海报会议将使所有与会者都能对这些专题作出贡献并了解这些专题。在Salve Regina University相对孤立的夏季环境中，免费的下午早些时候和傍晚时段将激发来自美国和国外的既定和初级主要研究人员，博士后学员和研究生之间富有成效的非正式讨论。这个应用程序的意义在于，这个GRC有一个独特的格式，并汇集了研究人员，尽管有共同的兴趣，很少有机会作为一个群体见面。由此产生的讨论和交流将有助于确定推动这一领域向前发展的关键领域。此外，阐明转录后基因调控的基本机制对于全面了解人类基因组的组织、功能和进化至关重要。这种应用的健康相关性反映了RNA加工功能障碍在许多遗传疾病、神经和神经肌肉疾病以及癌症中的广泛参与。1 公共卫生相关性：这种应用与公共卫生的相关性反映了与许多人类遗传疾病、神经和神经肌肉疾病以及癌症相关的RNA代谢缺陷的广泛参与。此外，阐明基因组网络以及基因调控步骤的基本机制，这是本次会议的重点，对于充分了解人类基因组的组织，功能和进化至关重要。

DESCRIPTION (provided by applicant): This proposal requests partial support for a Gordon Research Conference (GRC) on The Biology of Post- Transcriptional Gene Regulation, to be held at Salve Regina University in Newport, Rhode Island, from July 18th to July 23rd, 2010. This GRC is the fourth of a series that has been held every other year since 2004. The broad and long-term goal of the Conference is to improve our current understanding of fundamental mechanisms and regulation of RNA biogenesis in normal and disease states. The emphasis is on post- transcriptional transactions involving the generation and metabolism of mRNA, but this extends to transcriptional coupling, and to factors involved in translation and its control, including tRNA and non-coding (e.g., micro) RNAs. The Specific Aims of this meeting will be to convene approximately 45 internationally known speakers representing key areas of post-transcriptional gene regulation, with a total of 150 participants, for a five-day meeting. The program will consist of nine morning or evening sessions that will broadly address cutting-edge issues in: coupling between transcription and RNA processing; genomics and evolution of RNA- processing signals and factors (including defining sites that are targets for RNA-binding proteins normally and in disease using immunoprecipitation followed by microarrays or high-throughput sequencing); RNA splicing catalysis, fidelity, regulation, and involvement in disease; RNA turnover, including nonsense-mediated mRNA decay; RNA transport and localization; non-coding RNA; translational control; and RNA-protein interactions. In addition, small poster sessions on four late afternoons will enable all participants to contribute to, and learn about, these topics. Free early-afternoon and late-evening periods in the relatively isolated summer setting of Salve Regina University will stimulate productive, informal discussions among established and junior principal investigators, post-doctoral trainees and graduate students from the U.S. and abroad. The significance of this application is that this GRC has a unique format and brings together sets of researchers who, despite having converging interests, have infrequent opportunities to meet as a group. The resulting discussions and cross- fertilization will help define critical areas to propel this field forward. In addition, elucidating the basic mechanisms of post-transcriptional gene regulation will be essential to gain a full understanding of the organization, function, and evolution of the human genome. The health relatedness of this application reflects the extensive involvement of RNA-processing dysfunction in numerous genetic diseases, neurological and neuromuscular disorders, and cancer. 1 PUBLIC HEALTH RELEVANCE: The relevance of this application to public health reflects the extensive involvement of defects in RNA metabolism associated with many human genetic diseases, neurological and neuromuscular disorders, and cancer. In addition, elucidating genomic networks as well as the basic mechanisms of the steps of gene regulation, which are the focus of this conference, will be essential to gain a full understanding of the organization, function, and evolution of the human genome.