FASEB Summer Conference, July 20-25, 2002

FASEB 夏季会议，2002 年 7 月 20-25 日

• 批准号: 6507107
• 负责人: Fuyuhiko Tamanoi
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6507107
• 关键词: biological signal transduction; cell membrane; meeting /conference /symposium; neoplasm /cancer immunology; proteolipids; proteomics; travel

DESCRIPTION (provided by applicant): We request partial support for a Federation of American Societies of Experimental Biology (FASEB) conference on AProtein Lipidation, Signaling and Membrane Domains@, July 20-25, 2002 at Tucson, AZ. This meeting will feature exciting developments in the area of signal transduction, cancer research, immunology and infectious diseases. One highly topical focus concerns lipid rafts, cholesterol-rich membrane domains that function as organizing centers for signal transduction. The importance of this type of membrane domain in signal transduction in Cancer and Immunology is becoming increasingly clear. This field is expanding rapidly and this meeting provides a timely platform to discuss developments. Another timely topic that will be featured at this meeting concerns farnesyltransferase inhibitors (FTIs), rationally-designed anti-cancer drugs derived from the study of protein lipidation. FTIs inhibit prenylation and membrane association of proteins such as Ras. They inhibit tumor growth or even regress tumors in a variety of animal model systems and are currently being evaluated in phase II and III clinical trials. Insight obtained from the use of FTIs as well as related inhibitors GGTIs will be discussed. We will also feature anti-parasite drugs; in addition to the use of FTIs as anti-parasite drugs, drugs based on the study of GPI biosynthesis are emerging. In addition, novel insight into enzymes catalyzing thioacylation has been obtained, including the potential identification of the elusive first protein; fatty acyltransferases. Structural studies of the enzymes involved in protein prenylation and myristoylation have yield understanding at an atomic level. Studies on the transport and biosynthesis of prenylated proteins are beginning to uncover a novel intracellular transport pathway. Finally, gene knockouts in mice as well as in plants continue to provide novel insight into biological significance of protein lipidation. This, combined with the utilization of genomics and proteomics, is yielding a whole genome view of protein lipidation. This meeting will be a premier conference on the topic of membranes and protein lipidation. Our unique focus on lipid rafts and their significance in signal transduction as well as focus on cancer therapy and anti-parasite strategies promises to bring together a wide range of researchers.

描述（由申请人提供）： 我们请求对美国实验生物学学会联合会（FASEB）2002年7月20-25日在亚利桑那州图森举行的A蛋白质脂化、信号传导和膜结构域会议的部分支持。 这次会议将在信号转导，癌症研究，免疫学和传染病领域的令人兴奋的发展。 一个高度关注的焦点是脂筏，富含胆固醇的膜结构域，作为信号转导的组织中心。 这种类型的膜结构域在癌症和免疫学信号转导中的重要性越来越清楚。 这一领域正在迅速扩大，本次会议为讨论事态发展提供了一个及时的平台。 另一个及时的主题，将在这次会议上关注法尼基转移酶抑制剂（FTIs），合理设计的抗癌药物来自蛋白质脂化的研究。 FTIs抑制异戊二烯化和蛋白质如Ras的膜结合。 它们在各种动物模型系统中抑制肿瘤生长甚至使肿瘤消退，目前正在II期和III期临床试验中进行评估。 将讨论从使用FTI以及相关抑制剂GGTI获得的见解。 我们还将介绍抗寄生虫药物;除了使用FTIs作为抗寄生虫药物外，基于GPI生物合成研究的药物正在出现。 此外，新的洞察酶催化硫酰化已获得，包括潜在的第一个难以捉摸的蛋白质的鉴定;脂肪酰基转移酶。 对蛋白质异戊二烯化和肉豆蔻酰化中涉及的酶的结构研究已经在原子水平上产生理解。 对异戊二烯化蛋白质转运和生物合成的研究开始揭示一种新的细胞内转运途径。 最后，小鼠和植物中的基因敲除继续为蛋白质脂化的生物学意义提供新的见解。 这与基因组学和蛋白质组学的利用相结合，产生了蛋白质脂化的全基因组视图。 这次会议将是关于膜和蛋白质脂化主题的主要会议。 我们对脂筏及其在信号转导中的重要性的独特关注，以及对癌症治疗和抗寄生虫策略的关注，有望汇集广泛的研究人员。