FASEB Summer Conference, July 20-25, 2002

描述(由申请人提供)： 我们请求部分支持2002年7月20-25日在亚利桑那州图森市举行的美国实验生物学联合会(FASE B)关于AProtein脂化、信号和膜域的会议。这次会议将展示信号转导、癌症研究、免疫学和传染病领域令人兴奋的发展。 一个非常热门的焦点与脂筏有关，脂筏是一种富含胆固醇的膜域，起着信号转导组织中心的作用。这种类型的膜结构域在癌症和免疫学的信号转导中的重要性越来越明显。这一领域正在迅速扩大，这次会议为讨论事态发展提供了一个及时的平台。本次会议的另一个及时主题是关于法尼基转移酶抑制剂(FTI)，这是一种从蛋白质脂肪作用研究中衍生出来的合理设计的抗癌药物。FTI抑制RAS等蛋白质的苯丙基化和膜结合。它们在各种动物模型系统中抑制肿瘤生长，甚至使肿瘤消退，目前正在进行II期和III期临床试验。将讨论通过使用FTIs以及相关的抑制剂GGTIs获得的洞察力。我们还将以抗寄生虫药物为特色；除了将FTI用作抗寄生虫药物外，基于GPI生物合成研究的药物正在出现。此外，对催化硫代酰化的酶有了新的见解，包括对难以捉摸的第一种蛋白质--脂肪酰基转移酶的潜在鉴定。对参与蛋白质预烯基化和肉豆蔻基化的酶的结构研究已经在原子水平上获得了理解。对前烯基化蛋白质的运输和生物合成的研究开始揭示一种新的细胞内运输途径。最后，在老鼠和植物中的基因敲除继续为蛋白质脂肪作用的生物学意义提供新的见解。这一点与基因组学和蛋白质组学的利用相结合，产生了蛋白质脂肪作用的全基因组观点。 这次会议将是关于膜和蛋白质脂肪作用主题的首要会议。我们对脂筏及其在信号转导中的意义的独特关注，以及对癌症治疗和抗寄生虫策略的关注，有望将广泛的研究人员聚集在一起。

DESCRIPTION (provided by applicant): We request partial support for a Federation of American Societies of Experimental Biology (FASEB) conference on AProtein Lipidation, Signaling and Membrane Domains@, July 20-25, 2002 at Tucson, AZ. This meeting will feature exciting developments in the area of signal transduction, cancer research, immunology and infectious diseases. One highly topical focus concerns lipid rafts, cholesterol-rich membrane domains that function as organizing centers for signal transduction. The importance of this type of membrane domain in signal transduction in Cancer and Immunology is becoming increasingly clear. This field is expanding rapidly and this meeting provides a timely platform to discuss developments. Another timely topic that will be featured at this meeting concerns farnesyltransferase inhibitors (FTIs), rationally-designed anti-cancer drugs derived from the study of protein lipidation. FTIs inhibit prenylation and membrane association of proteins such as Ras. They inhibit tumor growth or even regress tumors in a variety of animal model systems and are currently being evaluated in phase II and III clinical trials. Insight obtained from the use of FTIs as well as related inhibitors GGTIs will be discussed. We will also feature anti-parasite drugs; in addition to the use of FTIs as anti-parasite drugs, drugs based on the study of GPI biosynthesis are emerging. In addition, novel insight into enzymes catalyzing thioacylation has been obtained, including the potential identification of the elusive first protein; fatty acyltransferases. Structural studies of the enzymes involved in protein prenylation and myristoylation have yield understanding at an atomic level. Studies on the transport and biosynthesis of prenylated proteins are beginning to uncover a novel intracellular transport pathway. Finally, gene knockouts in mice as well as in plants continue to provide novel insight into biological significance of protein lipidation. This, combined with the utilization of genomics and proteomics, is yielding a whole genome view of protein lipidation. This meeting will be a premier conference on the topic of membranes and protein lipidation. Our unique focus on lipid rafts and their significance in signal transduction as well as focus on cancer therapy and anti-parasite strategies promises to bring together a wide range of researchers.