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Enhancing host defence against intracellular pathogens by preventing iNOS interaction with a negative regulator, SSB-2

Enhancing host defence against intracellular pathogens by preventing iNOS interaction with a negative regulator, SSB-2
通过防止 iNOS 与负调节因子 SSB-2 相互作用,增强宿主对细胞内病原体的防御
批准号:
nhmrc : 637348
负责人:
A/Pr Sandra Nicholson
金额:
$29.93万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2010
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2010-01-01 至 2012-12-31

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中文摘要
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英文摘要
Secretion of nitric oxide (NO) gas by immune cells is a critical defence mechanism for the killing of intracellular pathogens. Production of NO within cells is regulated by the enzyme iNOS. We propose that preventing iNOS from interacting with its natural inhibitor protein (SSB-2) would allow enhanced and prolonged iNOS expression leading to increased NO and increased killing of pathogens such as the mycobacterium tuberculosis and the Leishmania parasite.
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