Enhancing host defence against intracellular pathogens by preventing iNOS interaction with a negative regulator, SSB-2

通过防止 iNOS 与负调节因子 SSB-2 相互作用，增强宿主对细胞内病原体的防御

• 批准号: nhmrc : 637348
• 负责人: A/Pr Sandra Nicholson
• 金额: $ 29.93万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/enhancing-host-defence-ssb-2/97095
• 关键词: Enhancing; host; defence; against; intracellular

Secretion of nitric oxide (NO) gas by immune cells is a critical defence mechanism for the killing of intracellular pathogens. Production of NO within cells is regulated by the enzyme iNOS. We propose that preventing iNOS from interacting with its natural inhibitor protein (SSB-2) would allow enhanced and prolonged iNOS expression leading to increased NO and increased killing of pathogens such as the mycobacterium tuberculosis and the Leishmania parasite.

免疫细胞分泌一氧化氮（NO）气体是杀死细胞内病原体的关键防御机制。细胞内 NO 的产生受 iNOS 酶的调节。我们认为，阻止 iNOS 与其天然抑制蛋白 (SSB-2) 相互作用将增强和延长 iNOS 表达，导致 NO 增加，并增加对结核分枝杆菌和利什曼原虫等病原体的杀灭。