Genome-wide investigation of bovine respiratory virus infection and host defence

牛呼吸道病毒感染和宿主防御的全基因组研究

• 批准号: 2885882
• 金额: --
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2885882
• 关键词: Genome; wide; investigation; bovine; respiratory

Bovine respiratory disease (BRD) - commonly known as "shipping fever" - affects millions of feedlot calves every year and, in addition to causing significant animal welfare issues, is a major cause of economic loss throughout the world. BRD is caused by a complex of pathogens including infection with respiratory viruses such as bovine respiratory syncytial virus (BRSV), bovine parainfluenza virus 3 (BPIV3), bovine herpes virus 1 (BoHV1). These pathogens cause damage to cells of the respiratory tract that hinders pulmonary clearance leaving calves susceptible to secondary bacterial infections. Therefore, a better understanding of virus biology, particularly what host factors are key to successful infection is needed. Likewise, knowledge of how the host defence system attempts to limit their replication is required to better inform the development of new therapeutic approaches or how to develop more sustainable and resilient animals.

牛呼吸道疾病（BRD）——通常被称为“运输热”——每年影响数百万只饲养场小牛，除了造成严重的动物福利问题外，也是世界各地经济损失的一个主要原因。BRD是由多种病原体引起的，包括感染呼吸道病毒，如牛呼吸道合胞病毒（BRSV）、牛副流感病毒3 （BPIV3）、牛疱疹病毒1 （BoHV1）。这些病原体对呼吸道细胞造成损害，阻碍肺部清除，使小牛易受继发性细菌感染。因此，需要更好地了解病毒生物学，特别是哪些宿主因素是成功感染的关键。同样，需要了解宿主防御系统如何试图限制它们的复制，以便更好地为开发新的治疗方法或如何开发更具可持续性和弹性的动物提供信息。