Increasing screening in families with colorectal cancer

加强对结直肠癌家族的筛查

• 批准号: 6546228
• 负责人: SUSAN M RAWL
• 金额: $ 15.05万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6546228
• 关键词: cancer risk; clinical research; disease /disorder prevention /control; family; genetic susceptibility; health behavior; human subject; interview; long term survivor; rectum neoplasms

DESCRIPTION (provided by applicant): First-degree relatives of colorectal cancer (CRC) survivors have a two- to threefold increased risk of developing the same disease. Screening which leads to removal of precancerous polyps has been shown to decrease CRC incidence by 75-90%. Despite their increased risk, rates of participation in CRC screening among first-degree relatives are low. Tailored print interventions which are based on theories of behavior change have demonstrated considerable promise as interventions that motivate people to change health behaviors. The primary purpose of the proposed study is to develop and test the readership, relevance, and satisfaction of a theoretically-based tailored print intervention designed to increase participation in CRC screening among first-degree relatives of CRC survivors. A secondary purpose is to estimate the effect size of the tailored print intervention through comparison with a generic print intervention. The tailored print intervention will contain messages that are individually tailored for each participant based on baseline assessment of their individual demographics, CRC risk factors, health beliefs (perceived risk, benefits, barriers, self-efficacy), and stages of change for CRC screening. This preliminary efficacy study contrasts groups of first-degree relatives who will be randomly assigned to receive the tailored print intervention or the generic print intervention. Participants will be 220 first-degree relatives referred by CRC survivors. Data will be collected via structured telephone interviews at baseline, one week post-intervention, and three months post-baseline. Assessments of readership, relevance, and satisfaction with the print interventions will conducted one week post-intervention. Comparisons between tailored and generic interventions on readership relevance and satisfaction will be made using chi-square tests of independence. Preliminary effects of the interventions on knowledge, perceived risk, benefits, barriers, and self-efficacy at three months will be assessed using ANCOVA models. Screening participation will be assessed in two ways; coverage and compliance. Intervention effects on coverage and compliance will be estimated with logistics models adjusting for each demographic, family history, and index patient characteristics. Transition probabilities for stage of change will be calculated separately for the intervention groups for each screening test.

描述（由申请人提供）：结直肠癌（CRC）幸存者的一级亲属具有两到三倍的增加，患有同一疾病的风险增加了。导致去除癌息肉的筛查已显示可将CRC发病率降低75-90％。尽管风险增加了，但一级亲戚参与CRC筛查的率很低。基于行为改变理论的量身定制的印刷干预措施表现出了巨大的希望，这是激励人们改变健康行为的干预措施。拟议的研究的主要目的是开发和测试基于理论的量身定制的印刷干预措施的读者群，相关性和满意度，旨在增加CRC幸存者一级亲戚参与的参与。次要目的是通过比较通用打印干预措施来估计量身定制的打印干预措施的效果。量身定制的打印干预措施将根据对个人人口统计学，CRC风险因素，健康信念（感知风险，福利，障碍，自我效能感）以及CRC筛查的变化阶段的基线评估，对每个参与者进行单独量身定制的信息。这项初步疗效研究与一级亲戚的群体进行了对比，他们将被随机分配接受量身定制的印刷干预措施或通用打印干预措施。参与者将是CRC幸存者提到的220个一级亲戚。数据将在基线，干预后一周和基线后三个月通过结构化电话采访来收集数据。对印刷干预措施的读者人数，相关性和满意度的评估将在干预后一周进行。量身定制干预措施与读者相关性和满意度之间的比较将使用卡方独立性测试进行。干预措施对三个月时的知识，感知风险，收益，障碍和自我效能感的初步影响将使用ANCOVA模型进行评估。筛查参与将通过两种方式进行评估；覆盖范围和合规性。干预对覆盖范围和合规性的影响将通过对每个人口统计，家族病史和索引患者特征进行调整的物流模型估计。对于每个筛查测试的干预组，将分别计算变化阶段的过渡概率。