Training in Biomolecular Pharmacology

描述(由申请人提供)：波士顿大学医学院生物分子药理学博士前项目于1997年7月获得NIGMS机构培训补助金。在过去的五年中，通过跨学科课程、实验室轮换和扩大研究培训机会，这一全大学范围的计划得到了全面实施。参与该计划的学术单位，药理学和实验治疗学，生物医学工程，生理学和生物物理学，以及分子医学，反映了培养具有从生物活性分子相互作用到疾病的分子基础和新的药物发现方法的药理学专业知识的博士科学家的目标。参与的教员最初是15人，现在是28人，他们贡献了从分子的计算、化学和生物学研究到阐明啮齿动物和灵长类动物模型的认知功能的培训专业知识。主要研究领域包括神经药理学、血管药理学、基因组学和蛋白质组学，辅以结构生物学和DNA、RNA和蛋白质化学的研究。除了医学园区的系外，波士顿大学查德斯河校区的生物医学工程系、化学系、生物学系和心理学系也设有培训地点。在第一年培训的夏天，惠氏研究公司与合作科学家一起进行的四到六周的实习被安排为一种可选的经历。自从NIGMS开始资助以来，17名博士前学生，包括一名代表不足的少数民族，得到了这笔赠款的支持，并得到了机构资源的补充。这些学生是从70多名符合条件的学生中挑选出来的，他们被四个参与的系和项目录取。博士候选人是根据他们本科和研究生水平的成就而被挑选出来的，主要是生物、化学和化学工程专业，以及他们作为分子药理学家的发展潜力。生物分子药理学计划通常需要学习五年，以达到预期的或综合水平的学术和研究生产力。这项续期申请寻求五年的资助，每年资助三名新生，但根据学生头两年的学习需要，将津贴从四笔增加到六笔。

DESCRIPTION (provided by applicant): The pre-doctoral Program in Biomolecular Pharmacology at Boston University School of Medicine received an NIGMS Institutional Training Grant in July of 1997. During the past five years, this University-wide Program has been fully implemented with an interdisciplinary curriculum, laboratory rotations, and expanded opportunities for research training. The academic units participating in this Program, Pharmacology and Experimental Therapeutics, Biomedical Engineering, Physiology and Biophysics, and Molecular Medicine, reflect the goal of producing doctoral scientists with pharmacologic expertise ranging from interactions of bioactive molecules to molecular basis of disease and novel approaches to drug discovery. Participating faculty, originally fifteen and now twenty-eight, contribute training expertise ranging from computational, chemical, and biological study of molecules to elucidation of cognitive function in rodent and primate models. The primary research areas include neuro-pharmacology, vascular pharmacology, and genomics and proteomics, supplemented by studies in structural biology and DNA, RNA, and protein chemistry. In addition to the departments at the medical campus, training sites are located in the Departments of Biomedical Engineering, Chemistry, Biology, and Psychology at the Chades River campus of Boston University. A four to six week internship with collaborating scientists at Wyeth Research has been arranged as an optional experience during the summer of the first year of training. Since inception of NIGMS funding, seventeen pre-doctoral students, including one underrepresented minority, have been supported from this grant, supplemented by institutional resources. These students were chosen from a pool of over seventy eligible students matriculating into the four participating departments and program. Ph.D. candidates have been selected based on the strength of their undergraduate and graduate-level achievement, primarily with majors in biology, chemistry, and chemical engineering, and their potential for development as molecular pharmacologists. The Bio-molecular Pharmacology Program generally entails study for five years to achieve the expected or integrative level of scholarship and research productivity. This renewal application seeks support for five years of funding for three new students each year but with an increase from four to six stipends in response to the need to support students during their first two years of study.