Neuroactive Steroids,Dopamine and Cocaine Sensitization

神经活性类固醇、多巴胺和可卡因致敏

基本信息

  • 批准号:
    6751694
  • 负责人:
  • 金额:
    $ 24.23万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-05-01 至 2006-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The mesotelencephalic dopamine system is implicated in the etiologies of schizophrenia and Parkinson's disease as well as in the reinforcing properties of psychostimulants, including cocaine and amphetamine. Recent evidence from our laboratory indicates that a number of neuroactive steroids influence dopamine transmission in the striatum by potentiating or inhibiting ionotropic glutamate receptor function. The major objective of this project is to follow up on these findings by assessing the activity of these neuroactive steroids in the nucleus accumbens, the limbic portion of the striatal complex that is the locus for the reinforcing effects of many drugs of abuse. To that end, we will assess the modulatory influence of neuroactive steroids on the behavioral and neurochemical effects of ionotropic glutamate receptor agonists in the core and shell of the nucleus accumbens. Using microdialysis (coupled with HPLC-EC and HPLC-MS) and behavioral techniques we will determine, i) the accumulation of systemically administered neuroactive steroids in the brain, ii) the behavioral and neurochemical consequences of neuroactive steroid modulation of ionotropic glutamate receptors in the nucleus accumbens shell, iii) the influence of neuroactive steroids on the initiation of behavioral sensitization to cocaine and iv) the influence of neuroactive steroids on cocaine priming-induced reinstatement of cocaine-seeking behavior. Collectively, these experiments will provide information on the activity of neuroactive steroids in the CNS, which will be invaluable for the development of steroids as potential pharmacological treatments for disorders involving ionotropic glutamate receptors in general and the craving associated with cocaine addiction in particular.
描述(由申请人提供):中脑端多巴胺系统是

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Inhibition of NMDA-induced striatal dopamine release and behavioral activation by the neuroactive steroid 3alpha-hydroxy-5beta-pregnan-20-one hemisuccinate.
神经活性类固醇 3α-羟基-5β-孕-20-一半琥珀酸酯抑制 NMDA 诱导的纹状体多巴胺释放和行为激活。
  • DOI:
    10.1046/j.1471-4159.2003.01814.x
  • 发表时间:
    2003
  • 期刊:
  • 影响因子:
    4.7
  • 作者:
    Sadri-Vakili,G;Johnson,DW;Janis,GC;Gibbs,TT;Pierce,RC;Farb,DH
  • 通讯作者:
    Farb,DH
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David H Farb其他文献

David H Farb的其他文献

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{{ truncateString('David H Farb', 18)}}的其他基金

Age-related Hypertension and Vascular Cognitive Impairment
年龄相关性高血压和血管性认知障碍
  • 批准号:
    10375761
  • 财政年份:
    2022
  • 资助金额:
    $ 24.23万
  • 项目类别:
Age-related Hypertension and Vascular Cognitive Impairment
年龄相关性高血压和血管性认知障碍
  • 批准号:
    10558579
  • 财政年份:
    2022
  • 资助金额:
    $ 24.23万
  • 项目类别:
Age-Related Changes in Neural Network Activity and Tau in a rat model of Alzheimer's Disease
阿尔茨海默病大鼠模型中神经网络活动和 Tau 蛋白与年龄相关的变化
  • 批准号:
    9530214
  • 财政年份:
    2018
  • 资助金额:
    $ 24.23万
  • 项目类别:
Training in Biomolecular Pharmacology
生物分子药理学培训
  • 批准号:
    9062038
  • 财政年份:
    2015
  • 资助金额:
    $ 24.23万
  • 项目类别:
Training in Biomolecular Pharmacology
生物分子药理学培训
  • 批准号:
    7892108
  • 财政年份:
    2009
  • 资助金额:
    $ 24.23万
  • 项目类别:
Neuroactive Steroids,Dopamine and Cocaine Sensitization
神经活性类固醇、多巴胺和可卡因致敏
  • 批准号:
    6624278
  • 财政年份:
    2002
  • 资助金额:
    $ 24.23万
  • 项目类别:
Neuroactive Steroids,Dopamine and Cocaine Sensitization
神经活性类固醇、多巴胺和可卡因致敏
  • 批准号:
    6473346
  • 财政年份:
    2002
  • 资助金额:
    $ 24.23万
  • 项目类别:
MOLECULAR NEUROBIOLOGY DIVISION
分子神经生物学部
  • 批准号:
    6455806
  • 财政年份:
    2001
  • 资助金额:
    $ 24.23万
  • 项目类别:
MOLECULAR NEUROBIOLOGY DIVISION
分子神经生物学部
  • 批准号:
    6344939
  • 财政年份:
    2000
  • 资助金额:
    $ 24.23万
  • 项目类别:
MOLECULAR NEUROBIOLOGY DIVISION
分子神经生物学部
  • 批准号:
    6314109
  • 财政年份:
    2000
  • 资助金额:
    $ 24.23万
  • 项目类别:
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