Training in Biomolecular Pharmacology

生物分子药理学培训

• 批准号: 9062038
• 负责人: David H Farb
• 金额: $ 8.48万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9062038
• 关键词: Pharmacology; Training

DESCRIPTION (provided by applicant): The predoctoral Training Program in Biomolecular Pharmacology at Boston University was launched in 1991 as a training center that would meld quantitative principles of biomedical engineering (BME) with pharmacology and experimental therapeutics, and was honored in July 1997 with the award of an NIGMS T32. In the succeeding 14 years, this university-wide program has continued to provide a supportive learning environment for predoctoral students. Program characteristics include an innovative curriculum, interdisciplinary laboratory rotations, an industrial summer internship, and diverse research training opportunities that span the Medical and Charles-River campuses. Students enter the Program via the Departments of Pharmacology or BME. Program trainees in BME and other departments experience an integrated curriculum designed to provide enriched training in the principles and practice of pharmacology that is coordinated with specialized training in their primary discipline. Trainees in Pharmacology gain access to diverse research and educational experiences that build upon those provided by core pharmacology faculty. The core curriculum stresses fundamental pharmacological principles as well as key issues governing interactions of bioactive molecules, challenges of drug delivery for novel therapeutics, animal models for drug action, their relevance to the clinic, and the challenges for modern drug discovery. Participating faculty, originally 21 and now 52, contribute expertise in focus areas including neuropharmacology, vascular and cancer pharmacology, genomics, gene therapy, proteomics, animal models (transgenic and behavioral), structural biology, nanotechnology, systems biology and medicinal chemistry. Sites for thesis research are also located in departments of Anatomy & Neurobiology, Biochemistry, Biology, Chemistry, Medicine, Neurology, Pathology, Physiology and Biophysics, Psychiatry, and Psychology. A major innovation implemented in 2010 is the university-wide Graduate Program for Neuroscience (GPN), which is attracting a large additional pool of high quality students with interests in pharmacological neuroscience. The Program has continued offering summer internships with collaborating scientists at local pharmaceutical companies. Career guidance with active oversight by faculty and senior student mentors engages trainees and provides leadership opportunities that are relevant to their career paths whether in academia, government or the private sector. Training duration is about 5.7 years and graduating students perform exceptionally well at competing for high level positions in various sectors. There are currently 46 students (41 TGE) in the program including 4 TGE from underrepresented minorities. This renewal application seeks funding for 8 trainees each year. The requested increase in the number of slots is to leverage the increased interest of highly qualified BME and GPN candidates in pharmacology training.

描述（由申请人提供）：波士顿大学生物分子药理学前培训培训计划于1991年启动，是一个培训中心，该中心将与药理学和实验治疗学融合生物医学工程（BME）的定量原理，并于1997年7月授予了Nigms T32的授予。在随后的14年中，该大学范围的计划继续为前学生提供支持性学习环境。课程特征包括创新的课程，跨学科实验室轮换，工业暑期实习以及跨越医疗和查尔斯 - 河流校园的各种研究培训机会。学生通过药理学或BME部门进入该计划。 BME和其他部门的计划培训人员经历了一项综合课程，旨在在药理学原理和实践中提供丰富的培训，并通过其主要学科的专门培训进行了协调。药理学学员获得了基于核心药理学教师提供的多种研究和教育经验。核心课程强调了基本的药理学原理以及有关生物活性分子相互作用的关键问题，药物递送的新型治疗学挑战，药物作用的动物模型，与诊所的相关性以及对现代药物发现的挑战。参与的教师最初是21岁，现在是52岁，在焦点领域提供了专业知识，包括神经药理学，血管和癌症药理学，基因组学，基因治疗，蛋白质组学，动物模型（转基因和行为），结构生物学，纳米技术，系统生物学和药物化学。论文研究的站点也位于解剖与神经生物学，生物化学，生物学，化学，医学，神经病学，病理学，生理学和生物物理学，精神病学和心理学的部门。 2010年实施的一项重大创新是大学范围内的神经科学研究生计划（GPN），该计划吸引了对药理学神经科学感兴趣的高质量高质量学生。该计划继续与当地制药公司的科学家合作提供暑期实习。教师和高级学生导师的积极监督的职业指导会吸引学员，并提供与学术界，政府或私营部门的职业道路相关的领导机会。培训时间约为5。7年，即将毕业的学生在争夺各个部门的高级职位方面表现出色。该计划中目前有46名学生（41个TGE），其中包括来自代表性不足的少数民族的4个TGE。该更新申请每年寻求8名学员的资金。所需的插槽数量增加是利用药理学培训中高素质的BME和GPN候选者的利益增加。