Training in Biomolecular Pharmacology

生物分子药理学培训

• 批准号: 7892108
• 负责人: David H Farb
• 金额: $ 8.7万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7892108
• 关键词: Pharmacology; Training

DESCRIPTION (provided by applicant): The predoctoral Program in Biomolecular Pharmacology at Boston University School of Medicine was initiated in 1990 and received this NIGMS Institutional Training Grant in 1997. In the ensuing ten years of NIGMS support, this university-wide program has flourished, providing a unique learning environment for doctoral students that combines an innovative curriculum, interdisciplinary laboratory rotations, and expanded opportunities for thesis research by bridging multiple departments across Boston University's two campuses. Students enter the program from one of three academic units: Pharmacology and Experimental Therapeutics (PET), Biomedical Engineering (BME), and Molecular Medicine (MM). Program trainees in BME and MM experience an integrated curriculum designed to provide enriched training in pharmacology that is coordinated with specialized training in their discipline while trainees in PET gain access to diverse research and educational experiences that build upon those provided by core pharmacology faculty. The curriculum stresses fundamental pharmacologic principles as well as key issues governing interactions of bioactive molecules, challenges of drug delivery for novel therapeutics, animal models and their relevance to the clinic, and the challenges for modern drug discovery. Participating faculty, originally fifteen and now forty-six, contribute expertise in focus areas including neuropharmacology, vascular and cancer pharmacology, genomics, proteomics, animal models (transgenic and behavioral), structural biology, and DMA, RNA, and protein chemistry. Sites for thesis research are also located in departments of Chemistry, Biology, Psychology, Neurology and Psychiatry. A summer internship with collaborating scientists at Wyeth Research has been fully implemented and career guidance and mentorship/leadership opportunities engage trainees with quality experiences that are relevant to their future careers in pharmacology both in academia and industry. Since inception, forty-two students have been supported by this NIGMS program that was one of the first to provide an interface for quantitatively trained BME students to link their core studies with training in pharmacological sciences. The program has continued this mission and expanded to position students with intellectual tools needed to advance drug discovery, medicine, and the future of global health by training the next generation of leaders equipped to translate basic research advances into medications.

描述（由申请人提供）：波士顿大学医学院生物分子药理学博士前项目于 1990 年启动，并于 1997 年获得 NIGMS 机构培训补助金。在接下来的 10 年 NIGMS 支持下，该大学范围内的项目蓬勃发展，为博士生提供了独特的学习环境，结合了创新课程、跨学科实验室轮换以及通过桥接扩大了论文研究的机会 波士顿大学两个校区的多个系。学生从三个学术单位之一进入该项目：药理学和实验治疗学（PET）、生物医学工程（BME）和分子医学（MM）。 BME 和 MM 项目的学员将体验综合课程，旨在提供丰富的药理学培训，并与其学科的专业培训相协调，而 PET 项目的学员则可以获得基于核心药理学教师提供的多样化研究和教育经验。该课程强调基本药理学原理以及控制生物活性分子相互作用的关键问题、新型疗法的药物输送挑战、动物模型及其与临床的相关性以及现代药物发现的挑战。参与的教员最初有 15 名，现在有 46 名，他们在神经药理学、血管和癌症药理学、基因组学、蛋白质组学、动物模型（转基因和行为）、结构生物学以及 DMA、RNA 和蛋白质化学等重点领域贡献专业知识。论文研究地点也位于化学、生物、心理学、神经病学和精神病学系。惠氏研究中心与合作科学家的暑期实习已经全面实施，职业指导和指导/领导机会让学员获得与他们未来在学术界和工业界药理学职业相关的优质经验。自启动以来，已有 42 名学生得到了 NIGMS 项目的支持，该项目是第一个为接受过定量培训的 BME 学生提供界面，将其核心研究与药理学培训联系起来的项目之一。该项目延续了这一使命，并通过培训下一代领导者将基础研究进展转化为药物，为学生提供推进药物发现、医学和全球健康未来所需的智力工具。