Development of novel and industrially-relevant liquid pharmaceutical formulations to enable paediatric combination drug therapy

开发新型且工业相关的液体药物制剂，以实现儿科联合药物治疗

• 批准号: 2098554
• 金额: --
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2098554
• 关键词: Development; novel; industrially; relevant; liquid

Co-encapsulation and co-delivery of two or more functional molecules from a single formulation is an emerging academic and industrial research field for a wide range of applications. More specifically, in the pharmaceutical industry there has been extensive research in this area, in order to develop fixed-dose combination (FDC) drugs to treat conditions where multiple active pharmaceutical ingredients (APIs) are required. Liquid formulations offer dosage flexibility, while addressing dosage form needs of specific patient populations (e.g. paediatrics). In addition, emulsions are attractive microstructures for the encapsulation/controlled delivery of functional molecules due to their multiphase attributes, ease of formation, as well as their utilisation in a number of structured liquid/semi-liquid products currently on the market. In this project, processing and formulation routes for the fabrication of novel sub-micrometre particles from pharmaceutically-relevant materials will be explored. The fabricated particles will be used to encapsulate an API of paediatric relevance, and different strategies will be developed to trigger and optimise the API release, while devising approaches to promote their Pickering functionality. Simple o/w emulsions will be employed to optimise the encapsulation and release of a secondary active ingredient. Once a better understanding of the mechanisms underpinning the encapsulation and release of a sole API from either particles or liquid droplets is achieved, the two will be combined to investigate the co-encapsulation and co-delivery of two APIs.

将两个或多个功能分子从单一配方中进行共封装和共输送是一个新兴的学术和工业研究领域，具有广泛的应用前景。更具体地说，在制药行业，已经在这一领域进行了广泛的研究，以开发固定剂量组合(FDC)药物来治疗需要多种活性药物成分(API)的情况。液体制剂提供了剂量灵活性，同时满足了特定患者群体(如儿科)的剂型需求。此外，由于乳液的多相性质、易于形成以及在目前市场上的许多结构化液体/半液体产品中的应用，乳液是用于包裹/控制输送功能分子的极具吸引力的微结构。在这个项目中，将探索从与药物相关的材料中制备新型亚微米颗粒的工艺和配方路线。制造的颗粒将被用来包裹一种与儿科相关的原料药，并将开发不同的策略来触发和优化原料药的释放，同时设计方法来促进其Pickering功能。将使用简单的O/W乳剂来优化二次活性成分的包封和释放。一旦更好地了解了从颗粒或液滴中包裹和释放单一原料药的机理，就将结合两者来研究两种原料药的共包裹和共传递。