PCBs, CYP1A1 Polymorphism and Breast Cancer Risk

PCB、CYP1A1 多态性与乳腺癌风险

• 批准号: 6356704
• 负责人: Tongzhang Zheng
• 金额: $ 27.43万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6356704
• 关键词: alcoholic beverage consumption; blood chemistry; breast neoplasms; cancer risk; clinical research; cytochrome P450; environment related neoplasm /cancer; female; gene environment interaction; genetic polymorphism; halobiphenyl /halotriphenyl compound; human subject; neoplasm /cancer epidemiology; neoplasm /cancer genetics; smoking; tobacco abuse; women's health

Construction industry is both one of the largest and one of the most dangerous industries in the United States. However, there is little literature on the different risk factors and risk groups within this industry. In this study we propose to do research on risk factors and risk groups in construction industry. Furthermore we will investigate the relation between working conditions and health in construction industry in a true longitudinal design, using an existing database. In the Netherlands, data is collected on a yearly basis on working conditions and health in construction industry. Construction workers have the opportunity to have a regular health checkup. The health checkup is performed on a voluntary basis, and at no cost to the employee. It consists of a physical exam (blood pressure, VO2-max, etc.) performed by the company health doctor and health nurse. When employees are invited to their health checkup, via a letter sent to their home address, they are asked to fill out a questionnaire. In the questionnaire, questions are asked about working conditions and health. All the activities the company health care services carry out for the construction industry are recorded in a computerized database. Only after the data has been recorded, are the company health services paid for the checkups. The computerized database (which is called VISA - a Dutch abbreviation for Activity Recording System Arbouw) includes data from the questionnaires filled out by the employees. These questionnaires are scanned and stored in a large database. Following this process, data from over 60,000 employees in the construction industry is collected every two years. To summarize, in the proposed study, we will use the longitudinal information in the database to evaluate risk factors and risk groups within construction industry and examine relations between working conditions and health in construction industry.

建筑业是美国最大的行业之一，也是最危险的行业之一。 然而，很少有文献对不同的风险因素和风险群体在这个行业。 在本研究中，我们建议对建筑业的风险因素和风险群体进行研究。 此外，我们将调查的工作条件和健康之间的关系，在建筑业在一个真正的纵向设计，使用现有的数据库。在荷兰，每年收集建筑业工作条件和健康方面的数据。建筑工人有机会定期进行健康检查。 健康检查是在自愿的基础上进行的，不收取员工任何费用。 它包括体格检查（血压，VO 2-max等）。由公司保健医生和保健护士进行。 当员工被邀请参加健康检查时，通过一封寄到他们家的信，他们被要求填写一份问卷。 在调查表中，询问了有关工作条件和健康的问题。 公司保健服务为建筑业开展的所有活动都记录在计算机化数据库中。 只有在数据被记录之后，公司保健服务部门才支付检查费用。 计算机化数据库（称为VISA -荷兰语活动记录系统Arbouw的缩写）包括雇员填写的调查问卷中的数据。 这些调查问卷被扫描并存储在一个大型数据库中。在这一过程之后，每两年收集一次建筑行业60，000多名员工的数据。总而言之，在拟议的研究中，我们将使用数据库中的纵向信息来评估建筑行业内的风险因素和风险群体，并研究建筑行业工作条件与健康之间的关系。