Hair coloring products & NHL--InterLymph-based analysis

描述(由申请人提供)： 在过去的几十年里，非霍奇金淋巴瘤(NHL)的发病率在世界各地的男性和女性中都急剧上升。尽管NHL具有相当大的公共卫生意义，但人们对其病因知之甚少。染发产品被认为是非霍奇金淋巴瘤的危险因素，因为一些成分被发现是诱变和/或致癌的。然而，流行病学研究的结果并不一致。几项流行病学研究表明，染发产品导致非霍奇金淋巴瘤的风险因疾病亚型和染发剂类型而异。然而，由于样本量小，个体流行病学研究考虑暴露和疾病亚型的风险因素对非霍奇金淋巴瘤的影响的能力一直受到限制。此外，由于染发剂配方的含量在1980年左右发生了变化，因此按使用时间段检查染发产品与非霍奇金淋巴瘤风险之间的关系是至关重要的，但以前的流行病学研究都没有按使用时间段来检查这种关系。考虑到每年有数百万人使用染发产品，以及染发产品使用与非霍奇金淋巴瘤风险之间关系的不确定性，迫切需要使用更大的样本量来评估染发剂对非霍奇金淋巴瘤的影响。致力于淋巴瘤流行病学研究的国际研究人员联盟(InterLymph)的成立是为了促进大型非霍奇金淋巴瘤流行病学研究之间的合作，为我们提供了一个探索染发产品和非霍奇金淋巴瘤之间关系的机会。因此，我们建议对作为InterLymph一部分的几项病例对照研究的数据进行汇集分析。这项综合分析的主要目的是确定非霍奇金淋巴瘤的风险是否与染发产品有关，以及这种风险是否因疾病亚型、染发产品类型和使用时间而异。这项基于InterLymph的汇集分析将包括在美国进行的三项基于人群的病例对照研究和在欧洲进行的一项多中心病例对照研究，从六个SEER地点和六个欧洲国家总共产生4893例经组织学确认的事件病例和6589例对照。几项大型流行病学研究的合作将导致样本量的增加，这将使我们能够有足够的统计能力来检查染发产品和非霍奇金淋巴瘤之间的联系的强度和一致性。

DESCRIPTION (provided by applicant): Over the past several decades, incidence rates of non-Hodgkin's lymphoma (NHL) have increased dramatically throughout the world among both men and women. In spite of the considerable public health significance, little is known about the etiology of NHL. Hair coloring products have been suggested as risk factors for NHL because some of the constituents have been found to be mutagenic and/or carcinogenic. However, the results from epidemiologic studies have been inconsistent. Several epidemiologic studies have suggested that the risk of NHL from hair coloring products varies by disease subtype and by the type of hair dyes. However, individual epidemiologic studies have been limited in their ability to consider the impact of risk factors on NHL by both exposure and disease subtypes because of small sample sizes. In addition, because hair dye formula contents have been changed around 1980, it is crucial to examine the relationship between hair coloring products and NHL risk by time period of use, but none of the previous epidemiological studies have examined this relationship by time period of use. Considering millions of people using hair coloring products each year and the uncertainty surrounding the relationship between hair coloring product use and risk of NHL, there exists an urgent need to assess the impact of hair dyes on NHL using a larger sample size. The International Consortium of Investigators Working on Lymphoma Epidemiologic Studies (InterLymph) was established to facilitate the cooperation between large, epidemiologic studies of NHL, providing us with an opportunity to explore the relationships between hair coloring products and NHL. Therefore, we propose to conduct a pooled analysis of data from several case-control studies that are a part of InterLymph. The primary aim of this pooled analysis is to determine if the risk of NHL is associated with hair coloring products, and whether this risk varies by disease subtype, type of hair coloring products, and time period of use. This InterLymph-based pooled analysis will include three population-based case-control studies conducted in the United States and one multi-center case-control study conducted in Europe, resulting in a total of 4,893 histologically-confirmed, incident cases and 6,589 controls, from six SEER sites and six European countries. The increased sample size that will result from the collaboration of several large, epidemiologic studies will enable us to have sufficient statistical power to examine the strength and consistency of the associations between hair coloring products and NHL.