Rapid Field Device For Measuring Arsenic in Water

快速现场测量水中砷的装置

• 批准号: 6549139
• 负责人: STEPHEN N BUNKER
• 金额: $ 10万
• 依托单位: IMPLANT SCIENCES CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-17 至 2003-08-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6549139
• 关键词: arsenic; bioengineering /biomedical engineering; biomedical equipment development; electrospray ionization mass spectrometry; environmental contamination; field study; ionization; lasers; measurement; monitoring device; portable biomedical equipment; rapid diagnosis; water pollution; water pollution control; water quality; water sampling /testing; water supply

DESCRIPTION (provided by applicant): The presence of arsenic in drinking water is both a national as well as a global concern due to the lack of field equipment capable of verifying compliance with EPA and WHO arsenic safety guidelines. Arsenic is a natural element found in the earth's crust and, when ingested chronically, results in vomiting, esophageal and abdominal pain, and diarrhea. Arsenic is also a proven carcinogen and has been linked to the onset of cancer of the skin, lungs, urinary bladder, and kidneys. Objective: Implant Sciences proposes to investigate a novel, two-stage technique for selectively ionizing arsenic in solution. When coupled with an ion mobility spectrometer, this technique would offer high ionization specificity and efficiency and is expected to result in a method of measuring arsenic in drinking water at concentrations as low as a few parts per trillion. The information obtained in this study would be used to manufacture a rugged and portable field device for quantifying drinking water compliance with EPA and WHO guidelines. Specific Aims: The specific goal of this phase I investigation is to investigate the feasibility of using a two stage ionization method to allow for the measurement of arsenic in water. A secondary goal of this project would be to prove that this two-stage technique would offer arsenic detection capabilities better than 100 ppt, with a desired target sensitivity of 1 ppt. To achieve this goal, an electrospray liquid conversion module will be built and tested for compatibility with a novel laser-enhanced ionization IMS system developed internally at Implant Sciences Corporation. Aqueous arsenic standards will be generated and used for the purposes of this investigation. The proposed IMS system will use these standards to initially identify the arsenic signal at the IMS output. Once the arsenic signal is identified, parameters such as the drift gas, gas pressure, laser energy and density, electrospray voltage and drift tube potential will be optimized to achieve ppt arsenic sensitivity.

描述（由申请人提供）：由于缺乏能够验证是否符合EPA和WHO砷安全指南的现场设备，饮用水中砷的存在是一个国家和全球问题。砷是一种存在于地壳中的天然元素，长期摄入会导致呕吐、食道和腹部疼痛以及腹泻。砷也是一种被证实的致癌物质，与皮肤癌、肺癌、膀胱癌和肾癌的发病有关。 目的：Implant Sciences提出研究一种新的两阶段技术，用于选择性电离溶液中的砷。当与离子迁移谱仪结合使用时，该技术将提供高电离特异性和效率，预计将导致测量饮用水中浓度低至万亿分之几的砷的方法。在这项研究中获得的信息将被用来制造一个坚固的和便携式的现场设备量化饮用水符合EPA和WHO的指导方针。 具体目标：第一阶段研究的具体目标是研究使用两阶段电离方法测量水中砷的可行性。该项目的第二个目标是证明这种两阶段技术将提供优于100 ppt的砷检测能力，所需的目标灵敏度为1 ppt。为了实现这一目标，将建立一个电喷雾液体转换模块，并测试其与植入物科学公司内部开发的新型激光增强电离IMS系统的兼容性。将生成水砷标准品，并用于本研究目的。拟议的国际监测系统将使用这些标准来初步确定国际监测系统输出处的砷信号。一旦识别出砷信号，将优化诸如漂移气体、气体压力、激光能量和密度、电喷雾电压和漂移管电势等参数以实现ppt砷灵敏度。