AL/ZIRCONIA COMPOSITE FILM FOR ORTHOPEDIC PROSTHESES

用于矫形假肢的铝/氧化锆复合薄膜

• 批准号: 2837568
• 负责人: STEPHEN N BUNKER
• 金额: $ 10万
• 依托单位: IMPLANT SCIENCES CORPORATION
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-15 至 1999-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2837568
• 关键词: X ray crystallography; aluminum; biomaterial development /preparation; biomaterial evaluation; ceramics; chemical synthesis; joint prosthesis; knee; medical implant science; orthopedics; spectrometry; surface coating; zirconium

Over 300,000 total knee replacement procedures are performed in the United States alone, and their performance is limited by wear. Coatings of ceramics are known to decrease wear of the ultra-high molecular weight polyethylene (UHMWPE) component of orthopedic joint replacements. Polyethylene wear debris is known to cause osteolysis which is a key factor in loosening of the prosthesis, leading to the need for a revision procedure. An alumina-zirconia composite is proposed as a new material to serve as the ceramic coating. With the hardness of alumina and the toughening effects of zirconia, the coating promises to be superior to either material alone. Both materials are biocompatible. The films will be coated by metalo-organic chemical vapor deposition (MOCVD), a method which is characterized by high growth rates and excellent surface conformality. Films will be coated at reduced and at atmospheric pressure onto CoCr surfaces which have been preconditioned with a thin ion-implanted layer of alumina. The important properties of film adhesion, composition, and hardness will be tested and analyzed. PROPOSED COMMERCIAL APPLICATIONS: This proposal addresses a process for increasing the lifetime of orthopedic devices in a manner which is nearly of equivalent cost compared to conventional ion implantation, which is presently being employed. ISC has production facilities for such implantation treatment having nitrogen ion implanted over 30,000 units to date. The proposed coating may represent at least one of the next generation solutions to the problem of enhanced service lifetime.

仅在美国就进行了超过30万例全膝关节置换术，其效果受到磨损的限制。众所周知，陶瓷涂层可以减少矫形关节置换物中超高分子量聚乙烯（UHMWPE）成分的磨损。聚乙烯磨损碎片已知会导致骨溶解，这是假体松动的关键因素，导致需要翻修手术。提出了一种氧化铝-氧化锆复合材料作为陶瓷涂层的新材料。由于氧化铝的硬度和氧化锆的增韧作用，该涂层有望优于单独使用任何一种材料。这两种材料都具有生物相容性。薄膜将通过金属有机化学气相沉积（MOCVD）进行涂层，这种方法具有高生长速率和良好的表面一致性。薄膜将在减压和常压下被涂在CoCr表面上，CoCr表面已经用一层薄薄的离子注入的氧化铝进行预处理。将测试和分析薄膜附着力、成分和硬度等重要性能。拟议的商业应用：该提案提出了一种增加骨科设备使用寿命的方法，与目前正在使用的传统离子注入相比，该方法的成本几乎相当。ISC拥有这种注入治疗的生产设施，迄今已注入3万多个氮离子。所建议的涂层可以代表延长使用寿命问题的下一代解决方案中的至少一种。

项目成果

Use of differentiating adult stem cells (marrow stromal cells) to identify new downstream target genes for transcription factors.

使用分化成体干细胞（骨髓基质细胞）来识别转录因子的新下游靶基因。

• DOI: 10.1634/stemcells.2005-0270
• 发表时间: 2006
• 期刊: Stem cells (Dayton, Ohio)
• 作者: Ylostalo,Joni;Smith,JasonR;Pochampally,RadhikaR;Matz,Robert;Sekiya,Ichiro;Larson,BenjaminL;Vuoristo,JussiT;Prockop,DarwinJ
• 通讯作者: Prockop,DarwinJ