Ultra-High resolution Acoustic Microscopy

超高分辨率声学显微镜

• 批准号: 6438959
• 负责人: BAHRAM JADIDIAN
• 金额: $ 16.58万
• 依托单位: J&W MEDICAL, LLC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6438959
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; biophysics; density; elasticity; histology; image enhancement; microscopy; sound

DESCRIPTION (provided by applicant): A novel, broadband scanning acoustic microscope (SAM) for in vivo imaging and characterization of micro-cellular biological tissue structures is proposed. It will operate at a frequency of 4.0 GHz, which offers a resolution of less than 0.4 microns, orders of magnitude less than that commercially available for medical diagnostic and non-destructive testing applications. The transducer will be fabricated by two methods: (1) utilizing a sol-gel process to grow the element as a single crystal, and (2) forming the element with pulsed laser deposition (PLD). Each pixel of an acoustic C-Scan image will provide information about the absorption, elastic properties and density of tissue cells, which may improve the visualization and clinical assessment of consistent patterns of cellular malignancy. The C-Scan image will be formed with a novel technique that utilizes a piezoelectric actuator for precise and reliable micro-stepping in a raster format for data acquisition and image presentation. A feasibility assessment of the clinical utility of the proposed design will be carried out at Thomas Jefferson University Hospital (Philadelphia., PA). Acoustic images will be taken of a wide variety of normal tissue specimens and the measured acoustic features compared with those obtained with standard transmissive and reflective optical techniques for tissue characterization. Proposed Commercial Application: A 4.0 GHz acoustic microscope offer significant benefits for both medical and material science applications. If successful, Layered Manufacturing Inc. is prepared to license the technology to all interested ultrasound system companies.

描述（由申请人提供）： 一种新型宽带扫描声学显微镜 (SAM)，用于体内成像和 提出了微细胞生物组织结构的表征。 它将在 4.0 GHz 频率下运行，分辨率更低 小于 0.4 微米，比市售产品小几个数量级 用于医疗诊断和无损检测应用。这 传感器将通过两种方法制造：（1）利用溶胶-凝胶工艺 将元件生长为单晶，并且（2）用以下方法形成元件： 脉冲激光沉积（PLD）。声学 C 扫描图像的每个像素将 提供有关吸收性、弹性特性和密度的信息 组织细胞，这可以改善可视化和临床评估 细胞恶性肿瘤的一致模式。将形成 C 扫描图像 采用一种新技术，利用压电致动器实现精确和 以光栅格式进行可靠的微步进，用于数据采集和图像 推介会。对所提议的临床效用的可行性评估 设计将在托马斯杰斐逊大学医院进行 （宾夕法尼亚州费城）。将拍摄各种正常情况的声学图像 组织样本和测量的声学特征与这些样本的比较 通过标准透射和反射光学技术获得 组织表征。 拟议的商业应用： 4.0 GHz 声学显微镜为医学和材料科学应用带来显着优势。如果成功，Layered Manufacturing Inc. 准备将该技术授权给所有感兴趣的超声系统公司。