High Resolution Dermatological Acoustic Microscopy

高分辨率皮肤声学显微镜

• 批准号: 6802012
• 负责人: BAHRAM JADIDIAN
• 金额: $ 22.78万
• 依托单位: J&W MEDICAL, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-18 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6802012
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; histopathology; melanoma; microscopy; skin disorder diagnosis; sound; swine

DESCRIPTION (provided by applicant): A novel, broadband dermatological scanning acoustic microscope (DSAM) for in vivo imaging and characterization of micro-cellular structures of the skin is proposed. It will operate over three frequency octaves, from 25 to 200 MHz, for detecting and screening dermatological cancer and environmentally induced diseases, providing tissue penetration to at least 1.0 cm and axial/lateral resolutions less than 8111microns at the skin surface. Each pixel of a cross-sectional B-Scan or planar C-Scan image will provide information about the absorption, elastic properties and density of tissue cells, which may improve the visualization and clinical assessment of consistent patterns of cellular malignancy. The transducer configuration will be a novel annular array comprised of a bundle of fine-grain ceramic fibers, filled with an epoxy to enhance its acoustic properties. A feasibility assessment of the clinical utility of the proposed design will be carried out at Thomas Jefferson University Hospital (Philadelphia. PA). The acoustic images will be obtained first of normal and abnormal histological swine tissue sections in vitro and then of a swine melanoma model in vivo. Measured acoustic features of the tissue specimens will be compared with those features obtained with standard optical techniques for tissue characterization. If the development of a dermatological scanning acoustic microscope (DSAM) is successful, then J&W Medical Inc. is prepared to explore a number of options for commercialization. This includes either licensing the technology, entering into a strategic alliance with a mature company looking for a novel medical imaging product, or seeking venture capital for in-house manufacturing.

描述（由申请人提供）：提出了一种新型的宽带皮肤扫描声学显微镜（DSAM），用于皮肤微细胞结构的体内成像和表征。它将在25至200 MHz的三个频率范围内工作，用于检测和筛查皮肤病癌症和环境引起的疾病，提供至少1.0厘米的组织穿透和皮肤表面的轴向/横向分辨率小于8111微米。横断面b扫描或平面c扫描图像的每个像素将提供有关组织细胞的吸收，弹性特性和密度的信息，这可能会改善细胞恶性肿瘤一致模式的可视化和临床评估。换能器的结构将是一种新型的环形阵列，由一束细颗粒陶瓷纤维组成，填充环氧树脂以增强其声学性能。将在托马斯·杰斐逊大学医院（费城）对拟议设计的临床效用进行可行性评估。PA)。首先在体外获得正常和异常组织学猪组织切片的声学图像，然后在体内获得猪黑色素瘤模型的声学图像。测量的声学特征的组织标本将与那些特征获得的标准光学技术的组织表征进行比较。