DESIGN/DEVELOPMENT OF HAP BONE SCAFFOLDS

HAP 骨支架的设计/开发

• 批准号: 6071239
• 负责人: BAHRAM JADIDIAN
• 金额: $ 9.99万
• 依托单位: LAYERED MANUFACTURING, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2001-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6071239
• 关键词: biomaterial development /preparation; bone prosthesis; ceramics; hydroxyapatites; medical implant science; tissue support frame

The replacement of damaged and/or lost bone due to traumatic and non- traumatic events is of considerable interest in medicine. Bioceramics have been used as bone grafts due to their non-toxic nature, biocompatibility, and controlled resorption. This research aims to establish the feasibility of fabricating porous hydroxyapatite (RAP) ceramic structures with unique designs that cannot be made by other available methods. This work will provide a relationship between the mechanical properties of the ceramic implants and the parameters associated with porosity. PROPOSED COMMERCIAL APPLICATION: The development of porous bioceramic materials using FDC technology will provide an opportunity to produce bone graft components with high mechanical strength, biocompatibility, and biodegradation. This process can have a significant impact in the field hard tissue repair and replacement, an industry with a worldwide annual turnover of $2.3 billion and a projected growth rate of 7-12% per year.

由于创伤性和非创伤性事件而导致的受损和/或丢失的骨的替换在医学中具有相当大的兴趣。 生物陶瓷由于其无毒、生物相容性和可控制的吸收而被用作骨移植物。 本研究的目的是建立制造多孔羟基磷灰石（RAP）陶瓷结构的可行性与独特的设计，不能由其他可用的方法。 这项工作将提供陶瓷植入物的机械性能和与孔隙率相关的参数之间的关系。拟定商业应用：使用FDC技术开发多孔生物陶瓷材料将为生产具有高机械强度、生物相容性和生物降解性的骨移植组件提供机会。 这一过程可以在硬组织修复和替换领域产生重大影响，该行业的全球年营业额为23亿美元，预计每年增长率为7-12%。