A Dual Electrospray/Photoionization Source

双电喷雾/光电离源

基本信息

批准号：
6444232
负责人：
Jack Albert Syage
金额：
$ 9.93万
依托单位：
SYAGEN TECHNOLOGY, INC.
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-04-01 至 2002-09-30
项目状态：
已结题

项目摘要

We propose a method to integrate an electrospray (ES) device to an atmospheric pressure photoionization (P I) source. We will employ a proprietary method to generate charged droplets that will undergo charge-repulsion to form volatilized analyte without producing ES positive ions. The positive ion spectrum will be due to PI only. By this means, the benefits of PI can be extended to non-volatile and thermally- labile compounds. PI has proven to be a general purpose ionization source for analyzing a wide variety of compounds, in many cases compounds not detectable by ES ionization (ESI) or atmospheric pressure chemical ionization (A PCI). PI is particularly well suited for drug-like compounds, and is much less susceptible to competition-for- charge and ion-suppression that affects ESI and APCI mass spectra. This proposal is a resubmission that contains new results that greatly raise the probability of success. We are confident that if provided SBIR seed money to test the feasibility in Phase I and solve the R&D issues in Phase II, that the ES/PI source would be immediately commercializable. The ES/PI source could also operate as an ES ionization source thereby providing dual ESI and PI capabilities for large molecules. The latter strategy would lead to rapid acceptance and widespread use in the pharmaceutical industry. PROPOSED COMMERCIAL APPLICATION: The pharmaceutical industry places increasingly greater demands on molecular analysis technology in terms of speed, quantitation, and generality. Development of a dual ESI/PI source would greatly expand capabilities and would be widely accepted into use as an enhanced ESI source.

我们提出了一种将电喷雾设备（ES）设备集成到大气压光电离（P I）源的方法。我们将采用一种专有方法来生成带电的液滴，这些液滴将经过电荷抑制，以形成挥发分析物而不会产生ES阳性离子。正离子光谱仅是由于Pi引起的。通过这种方式，PI的好处可以扩展到非易失性和热不稳定的化合物。事实证明，PI是分析多种化合物的通用电离源，在许多情况下，通过ES离子化（ESI）或大气压化学电离（PCI）无法检测到化合物。 PI特别适合类似药物的化合物，并且不太容易受到影响ESI和APCI质谱的竞争和离子抑制。该提案是一个重新提交，其中包含新的结果，可以极大地提高成功的可能性。我们有信心，如果提供SBIR种子资金来测试第一阶段的可行性并解决II阶段的研发问题，则ES/PI来源将立即商业化。 ES/PI源也可以作为ES电离源起作用，从而为大分子提供双ESI和PI功能。后一种策略将导致在制药行业的快速接受和广泛使用。拟议的商业应用：制药行业在速度，定量和一般性方面对分子分析技术的需求越来越大。双重ESI/PI来源的开发将大大扩展功能，并将被广泛接受为增强的ESI源。