Miniaturised 3D biomedical imaging: multimodal miniature microscope development

微型化 3D 生物医学成像：多模态微型显微镜的开发

• 批准号: 2104149
• 金额: --
• 依托单位: University of Strathclyde
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2104149
• 关键词: Miniaturised; 3D; biomedical; imaging; multimodal

The aim of the PhD project is the development of novel cost-effective, miniaturised biomedical imaging systems using MEMS (Microelectromechanical Systems) technology and active micro-optics. Emerging imaging technologies have contributed immensely to the understanding of biomedical development processes and interactions in recent times, with two Nobel Prices related to biomedical imaging techniques awarded in the last 5 years alone. These novel techniques are however still costly, limiting distribution and accessibility in less funded labs and developing countries.Tackling this availability gap, an approach of miniaturisation for the development of a miniaturised light sheet microscopy (LSM) system with complementary photoacoustic microscopy (PAM) readout is targeted in this studentship. LSM has the benefit of fast 3D fluorescence imaging with low light doses and low photo toxicity, allowing investigations of long term biomedical processes, while PAM has seen an increased research interest in recent years, with tomographic and optical resolution schemes implementing the benefit of label free, deep tissue imaging in biomedical applications. The project will develop new techniques to miniaturise and combine multiple imaging modalities, looking at increasing imaging depth and imaging potential in thick biological samples. This miniaturisation will be based on optical Microelectromechanical Systems (MEMS) technology, micro-optics and 3D-printing, with the student receiving support and gaining experience on all technological parts of this through the supervisors and further members of our research group working on biomedical imaging systems.The PhD position will benefit and contribute to a wider program of research on miniaturised biomedical imaging systems, sponsored by a RAEng Engineering for Development Research Fellowship which has active collaborative partners in developing countries, specifically India (Indian Institute of Technology Gandhinagar), as well as the United States (Stanford University) and Japan (University of Tokyo). The student will be expected to be integrated and contribute to these collaborative involvements, including the aim to spend time at the laboratories of collaborators.

博士项目的目的是开发新型的具有成本效益的，使用MEMS（微机电系统）技术和有源微光学的生物医学成像系统。近年来，新兴的成像技术为理解生物医学发展过程和相互作用做出了巨大贡献，仅在过去5年中就有两项与生物医学成像技术相关的诺贝尔奖。然而，这些新技术仍然昂贵，限制了资金较少的实验室和发展中国家的分布和可及性。为了解决这一可用性差距，本奖学金的目标是开发具有互补光声显微镜（PAM）读数的单光子片层显微镜（LSM）系统。LSM具有快速3D荧光成像的优点，具有低光剂量和低光毒性，允许长期生物医学过程的研究，而PAM近年来已经看到了越来越多的研究兴趣，断层扫描和光学分辨率方案实现了生物医学应用中无标记深层组织成像的好处。该项目将开发新技术，以增强和联合收割机多种成像模式，着眼于增加成像深度和厚生物样品的成像潜力。该专业将基于光学微机电系统（MEMS）技术，微光学和3D打印，学生将获得支持，并通过主管和我们研究小组的其他成员在生物医学成像系统方面获得所有技术部分的经验。博士学位将有利于并有助于更广泛的生物医学成像系统研究计划，该研究金在发展中国家有积极的合作伙伴，特别是印度（印度理工学院甘地讷格尔）以及美国（斯坦福大学）和日本（东京大学）。学生将被期望融入并为这些合作参与做出贡献，包括在合作者的实验室度过时间的目标。