PEDIATRIC ONCOLOGY PROGRAM

儿科肿瘤学项目

• 批准号: 6589984
• 负责人: Robert L Garcea
• 金额: $ 25.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-06 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6589984
• 关键词: Burkitt's lymphoma; Epstein Barr virus; acute lymphocytic leukemia; biological signal transduction; bone marrow transplantation; brain neoplasms; chimeric proteins; chromosome translocation; clinical research; cytogenetics; human subject; neoplasm /cancer genetics; oncogenic virus; oncology; pediatric neoplasm /cancer; transcription factor; virus related neoplasm /cancer

Description: (Applicant's Description) The Pediatric Oncology Program is comprised of clinical oncologists, surgeons, pathologists, and basic scientists whose interests are related to the diseases of pediatric cancer patients. The overall goal of the Pediatric Oncology Program is to reduce the cancer burden in the pediatric population by its research, education, and clinical programs. To accomplish this goal, the Program has established an integrated group of members, organized in four focus areas: 1) clinical investigations, 2) a clinical and research bone marrow transplant (BMT) program, 3) clinical translational research in leukemias, cytogenetics, and brain tumors, 4) basic science research in DNA tumor viruses, lymphocyte signal transduction, and fusion protein transcription factors created by chromosomal translocations in childhood ALL. The clinical program is an active participant in the Children?s Cancer Group (CCG), and utilizes investigator-initiated protocols developed by Cancer Center members and by the cooperative group whenever possible. Each year approximately 150 new oncology patients are evaluated and/or treated by the oncology staff, and an additional 25-35 children are transplanted on various protocols in the pediatric BMT unit. Protocol development over the past year has included 13 investigator-initiated and 49 CCG protocols, with 153 patients enrolled. Program members are highly interactive with respect to clinical protocol development, translational research, and basic research, as evidenced by the fact that 36% of the 132 publications have intra-or inter-program collaborations despite the fact that most members are new. Future plans will build upon this foundation of interaction in specific areas including: 1)continue integration of Pediatric and Adult programs in Neuro-oncology and BMT; 2)development of a Cancer Genetics Clinic to serve as a focus for new translational and basic research; 3)establishment of a clinical and basic research interest group for studying EBV-related lymphoproliferative disease; 4)increased research in cancer survivorship; and 5)faculty career development for new translational and basic scientists interested in areas related to Pediatric Oncology. This is one of a few approved Pediatric Oncology programs within NCI designated Comprehensive Cancer Centers whose growth has been supported by the UCCC and whose growth is projected to continue in the next five years.

描述：（申请人的描述）小儿肿瘤学计划是 包括临床肿瘤学家，外科医生，病理学家和基本 与小儿癌症有关的科学家 患者。小儿肿瘤学计划的总体目标是减少 儿科人群的癌症负担通过其研究，教育和 临床计划。为了实现这一目标，该计划已经建立了一个 综合成员组，在四个重点领域组织：1）临床 研究，2）临床和研究骨髓移植（BMT） 计划，3）白血病，细胞遗传学和 脑肿瘤，4）DNA肿瘤病毒的基础科学研究，淋巴细胞 信号转导和融合蛋白转录因子由 童年时期的染色体易位。临床计划是一个活跃的 参与儿童癌症组（CCG），并使用 癌症中心成员制定的研究者发起的协议和 尽可能的合作小组。每年大约有150个新肿瘤学 肿瘤学人员对患者进行评估和/或治疗 25-35名儿童在小儿BMT中的各种方案上移植 单元。 过去一年的协议开发包括13个调查员发起的 和49种CCG方案，有153例患者。计划成员高度 关于临床方案开发，翻译的交互 研究和基础研究，这一事实证明了132个中的36％ 尽管事实是 大多数成员都是新成员。未来计划将基于这个基础 特定领域的相互作用包括：1）继续整合小儿 以及神经肿瘤学和BMT的成人计划； 2）癌症的发展 遗传学诊所将成为新的转化和基础研究的重点； 3）建立一个研究临床和基础研究兴趣小组 与EBV相关的淋巴增生性疾病； 4）增加癌症的研究 生存； 5）新的翻译和基本的教师职业发展 对与小儿肿瘤学有关的领域感兴趣的科学家。这是一个 NCI指定综合的批准的小儿肿瘤学计划 癌症中心的增长得到了UCCC的支持，其增长是 预计将在未来五年内持续。