PEDIATRIC ONCOLOGY PROGRAM

儿科肿瘤学项目

• 批准号: 6589984
• 负责人: Robert L Garcea
• 金额: $ 25.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-06 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6589984
• 关键词: Burkitt's lymphoma; Epstein Barr virus; acute lymphocytic leukemia; biological signal transduction; bone marrow transplantation; brain neoplasms; chimeric proteins; chromosome translocation; clinical research; cytogenetics; human subject; neoplasm /cancer genetics; oncogenic virus; oncology; pediatric neoplasm /cancer; transcription factor; virus related neoplasm /cancer

Description: (Applicant's Description) The Pediatric Oncology Program is comprised of clinical oncologists, surgeons, pathologists, and basic scientists whose interests are related to the diseases of pediatric cancer patients. The overall goal of the Pediatric Oncology Program is to reduce the cancer burden in the pediatric population by its research, education, and clinical programs. To accomplish this goal, the Program has established an integrated group of members, organized in four focus areas: 1) clinical investigations, 2) a clinical and research bone marrow transplant (BMT) program, 3) clinical translational research in leukemias, cytogenetics, and brain tumors, 4) basic science research in DNA tumor viruses, lymphocyte signal transduction, and fusion protein transcription factors created by chromosomal translocations in childhood ALL. The clinical program is an active participant in the Children?s Cancer Group (CCG), and utilizes investigator-initiated protocols developed by Cancer Center members and by the cooperative group whenever possible. Each year approximately 150 new oncology patients are evaluated and/or treated by the oncology staff, and an additional 25-35 children are transplanted on various protocols in the pediatric BMT unit. Protocol development over the past year has included 13 investigator-initiated and 49 CCG protocols, with 153 patients enrolled. Program members are highly interactive with respect to clinical protocol development, translational research, and basic research, as evidenced by the fact that 36% of the 132 publications have intra-or inter-program collaborations despite the fact that most members are new. Future plans will build upon this foundation of interaction in specific areas including: 1)continue integration of Pediatric and Adult programs in Neuro-oncology and BMT; 2)development of a Cancer Genetics Clinic to serve as a focus for new translational and basic research; 3)establishment of a clinical and basic research interest group for studying EBV-related lymphoproliferative disease; 4)increased research in cancer survivorship; and 5)faculty career development for new translational and basic scientists interested in areas related to Pediatric Oncology. This is one of a few approved Pediatric Oncology programs within NCI designated Comprehensive Cancer Centers whose growth has been supported by the UCCC and whose growth is projected to continue in the next five years.

描述：(申请者描述)儿科肿瘤学专业是 由临床肿瘤学家、外科医生、病理学家和基础 对儿童癌症疾病感兴趣的科学家 病人。儿科肿瘤学计划的总体目标是减少 儿科人群的癌症负担由其研究、教育和 临床项目。为了实现这一目标，该方案建立了一个 整合的成员小组，按四个重点领域组织：1)临床 调查，2)临床和研究骨髓移植(BMT) 方案，3)白血病的临床翻译研究，细胞遗传学，和 脑肿瘤，4)DNA肿瘤病毒，淋巴细胞的基础科学研究 信号转导和融合蛋白转录因子 儿童ALL的染色体易位。临床方案是一项积极的 儿童-S癌症小组的参与者，并利用 由研究人员发起的由癌症中心成员和 只要有可能，就组成合作小组。每年大约有150个新的肿瘤科 由肿瘤科工作人员对患者进行评估和/或治疗，并另外 在儿科BMT中，25-35名儿童通过不同的方案进行移植 单位。 在过去的一年里，礼仪的制定包括13名调查人员发起的 CCG方案49例，入选患者153例。计划成员高度重视 关于临床方案开发的互动、翻译 研究和基础研究，这一事实证明了132人中的36% 出版物有计划内或计划间的合作，尽管事实是 大多数成员都是新成员。未来的计划将建立在这一基础上 具体领域的互动包括：1)继续整合儿科 和成人神经肿瘤学和骨髓移植计划；2)癌症的发展 遗传学诊所将成为新的翻译和基础研究的重点； 3)建立临床和基础研究学习兴趣小组 EB病毒相关淋巴增生性疾病；4)增加癌症研究 生存能力；5)新的翻译和基础专业的教师职业发展 对儿科肿瘤学相关领域感兴趣的科学家。这是一个 NCI指定的综合性儿科肿瘤学项目寥寥无几 由UCCC支持的癌症中心，其增长是 预计在未来五年内将继续下去。