PEDIATRIC ONCOLOGY PROGRAM

儿科肿瘤学项目

• 批准号: 6664439
• 负责人: Robert L Garcea
• 金额: $ 25.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-06 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6664439
• 关键词: Burkitt's lymphoma; Epstein Barr virus; acute lymphocytic leukemia; biological signal transduction; bone marrow transplantation; brain neoplasms; chimeric proteins; chromosome translocation; clinical research; cytogenetics; human subject; neoplasm /cancer genetics; oncogenic virus; oncology; pediatric neoplasm /cancer; transcription factor; virus related neoplasm /cancer

Description: (Applicant's Description) The Pediatric Oncology Program is comprised of clinical oncologists, surgeons, pathologists, and basic scientists whose interests are related to the diseases of pediatric cancer patients. The overall goal of the Pediatric Oncology Program is to reduce the cancer burden in the pediatric population by its research, education, and clinical programs. To accomplish this goal, the Program has established an integrated group of members, organized in four focus areas: 1) clinical investigations, 2) a clinical and research bone marrow transplant (BMT) program, 3) clinical translational research in leukemias, cytogenetics, and brain tumors, 4) basic science research in DNA tumor viruses, lymphocyte signal transduction, and fusion protein transcription factors created by chromosomal translocations in childhood ALL. The clinical program is an active participant in the Children?s Cancer Group (CCG), and utilizes investigator-initiated protocols developed by Cancer Center members and by the cooperative group whenever possible. Each year approximately 150 new oncology patients are evaluated and/or treated by the oncology staff, and an additional 25-35 children are transplanted on various protocols in the pediatric BMT unit. Protocol development over the past year has included 13 investigator-initiated and 49 CCG protocols, with 153 patients enrolled. Program members are highly interactive with respect to clinical protocol development, translational research, and basic research, as evidenced by the fact that 36% of the 132 publications have intra-or inter-program collaborations despite the fact that most members are new. Future plans will build upon this foundation of interaction in specific areas including: 1)continue integration of Pediatric and Adult programs in Neuro-oncology and BMT; 2)development of a Cancer Genetics Clinic to serve as a focus for new translational and basic research; 3)establishment of a clinical and basic research interest group for studying EBV-related lymphoproliferative disease; 4)increased research in cancer survivorship; and 5)faculty career development for new translational and basic scientists interested in areas related to Pediatric Oncology. This is one of a few approved Pediatric Oncology programs within NCI designated Comprehensive Cancer Centers whose growth has been supported by the UCCC and whose growth is projected to continue in the next five years.

描述：（申请人描述）儿科肿瘤学项目是 包括临床肿瘤学家、外科医生、病理学家和基础 研究儿童癌症的科学家 患者儿科肿瘤学项目的总体目标是减少 癌症负担在儿科人口通过其研究，教育， 临床方案。为了实现这一目标，该方案建立了一个 综合小组成员，组织在四个重点领域：1）临床 2）临床和研究骨髓移植（BMT） 项目，3）白血病，细胞遗传学的临床转化研究， 脑肿瘤，4）DNA肿瘤病毒，淋巴细胞的基础科学研究 信号转导和融合蛋白转录因子， 儿童ALL中的染色体易位。临床项目是一个积极的 参与儿童？的癌症组（CCG），并利用 由癌症中心成员和 只要有可能，合作伙伴。每年约有150个新的肿瘤 患者由肿瘤科工作人员进行评估和/或治疗， 在儿科BMT中，25-35名儿童根据各种方案进行移植 单位 在过去一年中， 和49个CCG方案，153例患者入组。节目组成员高度 与临床协议开发、翻译 研究和基础研究，这一事实证明，132个 出版物有内部或跨计划的合作，尽管事实上， 大多数成员是新成员。未来的计划将建立在这一基础上， 具体领域的互动，包括：1）继续整合儿科 神经肿瘤学和BMT的成人课程; 2）癌症的发展 遗传学诊所作为新的转化和基础研究的重点; 3)建立临床和基础研究兴趣小组， EB病毒相关淋巴增生性疾病; 4）癌症研究增加 生存;和5）教师职业发展的新的翻译和基础 对儿科肿瘤学相关领域感兴趣的科学家。这是一个 在NCI指定的综合性项目中，少数批准的儿科肿瘤学项目 癌症中心的发展得到了UCCC的支持，并且其发展是 预计将在未来五年继续。