Application of novel cellular target engagement technologies to interrogate the IL23R-JAK/TyK2-STAT signalling pathway

许多生物学过程是基于内源性配体的结合和形成信号级联的一部分的其他蛋白质-蛋白质相互作用。了解这些信号级联的核心组成部分和相互作用仍然是难以捉摸的一些细胞机制与有限的工具可用于帮助解卷积。这项研究旨在利用NanoBRET示踪剂和蛋白质-蛋白质相互作用（PPI）技术来靶向和更好地了解细胞背景下已知信号通路（IL 23 R/JAK家族/STAT）的元件。

Many biological processes are predicated on the binding of endogenous ligands and other protein-protein interactions that form part of a signaling cascade. Understanding the core components and interactions of these signaling cascades is still elusive for a number of cellular mechanisms with limited tools available to aid deconvolution. This study seeks to utilise the NanoBRET Tracer and protein-protein interaction (PPI) technology to target and better understand elements of a known signaling pathway (IL23R/JAK family/STAT) in a cellular context.