Low-field NMR and MRI using in situ parahydrogen hyperpolarisation
使用原位仲氢超极化的低场 NMR 和 MRI
基本信息
- 批准号:2107388
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2018
- 资助国家:英国
- 起止时间:2018 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) spectroscopy are powerful tools for applications that range from synthetic chemistry to medical diagnosis. However, these methods suffer from low sensitivity because only tens out of every million atomic nuclei in the sample being studied are actually detected. For example, the fraction of the 1H nuclei that are detected in standard NMR experiments is approximately 3.5 ppm for every Tesla of magnetic field that is applied. Therefore, only relatively large quantities of substances can be investigated and expensive high-magnetic-field devices are required. One promising route to dramatically improving magnetic resonance is through the use of hyperpolarisation. This is the name given to methods that increase the fraction of detected nuclei by perturbing the nuclear spin state populations far from equilibrium. One of the areas of magnetic resonance made possible by hyperpolarisation is the use of low-cost NMR and MRI devices that generate the necessary magnetic field using either simple electromagnets (tens of mT) or even the Earth's magnetic field (50 uT). The aims of this project are to develop optimised hyperpolarisation strategies for uT-mT NMR and MRI and to explore the potential applications of this technology, particularly as a low-cost analytical tool for industrial use. The focus will be on the SABRE (signal amplification by reversible exchange) method, which uses a form of hydrogen gas known as parahydrogen (p-H2), to generate the hyperpolarisation effect. Specifically, SABRE uses a transition metal complex to catalytically transfer polarisation from parahydrogen (the singlet nuclear spin isomer of H2) to a molecule of interest in solution thereby increasing the detectability of the target molecule by many orders of magnitude. A key feature of SABRE is that the exchange reaction step, where the polarisation transfer takes place, must be carried out in a very low field of a few mT in order for the transfer to be efficient. In the standard approach, SABRE polarisation transfer is achieved over a period of seconds in a mT field (called the polarisation transfer field or PTF) and then the sample is transported (either manually or under flow) to the NMR spectrometer for signal detection at a much stronger field (> 1T). In this project, the SABRE polarisation transfer and the subsequent NMR detection will be carried out in situ, without the need to shuttle the sample between two different fields. The in situ approach will be exploited to directly probe the polarisation transfer process and so obtain new physical insights into the SABRE technique for a range of chemical systems. These insights will be used to design and implement new methods for optimising polarisation transfer, particularly for diagnostically important nuclei such as 13C. The optimised hyperpolarisation methods will then be used to develop novel methods to obtain chemically diagnostic information in the uT - mT regime, where chemical shift resolution is unavailable. This will include the use of imaging as well as NMR parameters such as molecular self-diffusion, heteronuclear scalar (J) coupling, and NMR relaxation rates to differentiate the hyperpolarised responses from different chemical species.
磁共振成像(MRI)和核磁共振(NMR)光谱学是应用范围从合成化学到医学诊断的强大工具。然而,这些方法的灵敏度很低,因为在被研究的样品中,每一百万个原子核中只有几十个真正被检测到。例如,在标准的核磁共振实验中,每施加一个特斯拉的磁场,检测到的1H原子核的比例约为3.5 ppm。因此,只有相对大量的物质才能被研究,并且需要昂贵的高磁场设备。一个有希望显著改善磁共振的途径是使用超极化技术。这是一种通过干扰远离平衡态的核自旋态居群来增加被探测到的核的比例的方法。超极化使磁共振成为可能的一个领域是使用低成本的核磁共振和核磁共振设备,这些设备使用简单的电磁铁(几十mT)甚至地球磁场(50 uT)产生必要的磁场。该项目的目的是为uT-mT NMR和MRI开发优化的超极化策略,并探索该技术的潜在应用,特别是作为工业使用的低成本分析工具。重点将放在SABRE(可逆交换信号放大)方法上,该方法使用一种被称为对氢(p-H2)的氢气形式来产生超极化效应。具体来说,SABRE使用过渡金属配合物将对氢(H2的单线态核自旋异构体)的极化催化转移到溶液中的感兴趣分子,从而将目标分子的可探测性提高了许多数量级。SABRE的一个关键特点是,交换反应步骤,即极化转移发生的地方,必须在几mT的非常低的场中进行,以便有效地转移。在标准方法中,在mT场(称为极化转移场或PTF)中,SABRE极化转移在几秒钟内实现,然后将样品(手动或流式)传输到核磁共振光谱仪,以便在更强的场(bbb1t)下进行信号检测。在这个项目中,SABRE极化转移和随后的核磁共振检测将在原位进行,而不需要在两个不同的场之间穿梭样品。原位方法将被用于直接探测极化转移过程,从而为一系列化学系统获得SABRE技术的新物理见解。这些见解将用于设计和实施优化极化转移的新方法,特别是对于诊断上重要的原子核,如13C。优化的超极化方法将用于开发新的方法,以获得uT - mT体系中的化学诊断信息,其中化学位移分辨率不可用。这将包括使用成像以及核磁共振参数,如分子自扩散、异核标量(J)耦合和核磁共振弛豫率,以区分来自不同化学物质的超极化反应。
项目成果
期刊论文数量(0)
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其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
- DOI:
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LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
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2021 - 期刊:
- 影响因子:0
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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