PROCEDURES TO ASSESS THE HAZARDS OF A SUPERFUND SITE

对超级基金场址的危害和风险评估是制定清理战略和确定场址优先次序的重要先决条件。德克萨斯A&M大学超级基金基础研究计划（SBRP）的主要主题是进行基础研究，以减少复杂混合物风险评估的不确定性，并提高科学和公众对整体风险评估过程的信心。SBRP包括四个生物科学项目，两个工程研究（项目5和6），和人口研究。毒理学研究包括以下研究：（1）确定内分泌干扰的机制;（2）调查复杂混合物的遗传毒性相互作用;（3）了解压力调节蛋白对细胞保护的影响;以及（4）确定敏感基因型项目5将开发化学干预技术，以补救与不同类别的超级基金污染物相关的风险。暴露评估和建模（项目6）研究将侧重于确定三个研究领域的主要污染物。环境评估的数据将用于建立有毒化学品向野生动物或人类迁移和吸收的模型，并估计与环境有关的剂量，供毒理学研究（项目1-3）测试。还将在项目6中开展研究，调查复杂混合物的生物利用率，对有希望的污染混合物补救技术进行实地试验，并对有希望的污染环境补救技术进行实地试验。最后，项目7（环境污染、遗传因素和先天性畸形）将综合所有研究的结果，并调查污染物暴露程度不同的地区化学品引起的人类健康问题。这项研究将得到服务核心、行政和培训核心以及一个侧重于公众和利益攸关方社区沟通和教育的外联核心的支持。

Hazard and risk assessment of Superfund sites is an important prerequisite for development of strategies for cleanup and for site prioritization. The major theme of the Superfund Basic Research Program (SBRP) at Texas A&M University us to conduct fundamental research to reduce uncertainties with risk assessment of complex mixtures, and to improve scientific and public confidence in the overall risk assessment process. The SBRP consists of four biological science projects, two engineering studies (Projects 5 and 6), and a population study. The toxicological research include research to: (1) identify mechanisms of endocrine disruption; (2) investigate the genotoxic interactions of complex mixtures; (3) understand the affect of a stress regulation protein on cytoprotection; and (4) identify sensitive genotypes Project 5 will develop chemical intervention technologies to remediate risks associated with different classes of Superfund contaminants. Exposure Assessment and Modeling (Project 6) studies will focus on identification of the major contaminants in three study areas. The data from environmental assessments will be used to model the transport and uptake of toxic chemicals to wildlife or humans, and to estimate environmentally relevant doses for testing in toxicological studies (Projects 1-3). Studies will also be conducted in Project 6 to investigate bioavailability of complex mixtures and to conduct field trials of promising techniques for remediation of contaminated mixtures and to conduct field trials of promising techniques for remediation of contaminated environments. Finally, Project 7 (Environmental Contamination, Genetic Factors and Congenital Malformations) will integrate ongoing results from all studies and investigate chemical-induced human health problems in regions with different levels of contaminant exposure. This research will be supported by service cores, administrative and training cores, and an outreach core that will focus on communication and education of the public and stakeholder community.