PROCEDURES TO ASSESS THE HAZARDS OF A SUPERFUND SITE

评估超级基金场所危害的程序

• 批准号: 6518053
• 负责人: Stephen H. Safe
• 金额: $ 103.52万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-12-12 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6518053
• 关键词: environmental toxicology

Hazard and risk assessment of Superfund sites is an important prerequisite for development of strategies for cleanup and for site prioritization. The major theme of the Superfund Basic Research Program (SBRP) at Texas A&M University us to conduct fundamental research to reduce uncertainties with risk assessment of complex mixtures, and to improve scientific and public confidence in the overall risk assessment process. The SBRP consists of four biological science projects, two engineering studies (Projects 5 and 6), and a population study. The toxicological research include research to: (1) identify mechanisms of endocrine disruption; (2) investigate the genotoxic interactions of complex mixtures; (3) understand the affect of a stress regulation protein on cytoprotection; and (4) identify sensitive genotypes Project 5 will develop chemical intervention technologies to remediate risks associated with different classes of Superfund contaminants. Exposure Assessment and Modeling (Project 6) studies will focus on identification of the major contaminants in three study areas. The data from environmental assessments will be used to model the transport and uptake of toxic chemicals to wildlife or humans, and to estimate environmentally relevant doses for testing in toxicological studies (Projects 1-3). Studies will also be conducted in Project 6 to investigate bioavailability of complex mixtures and to conduct field trials of promising techniques for remediation of contaminated mixtures and to conduct field trials of promising techniques for remediation of contaminated environments. Finally, Project 7 (Environmental Contamination, Genetic Factors and Congenital Malformations) will integrate ongoing results from all studies and investigate chemical-induced human health problems in regions with different levels of contaminant exposure. This research will be supported by service cores, administrative and training cores, and an outreach core that will focus on communication and education of the public and stakeholder community.

超级基金场址的危害和风险评估是制定清理战略和确定场址优先次序的重要前提。德克萨斯A&M大学超级基金基础研究计划（SBRP）的主要主题是开展基础研究，以减少复杂混合物风险评估的不确定性，并提高科学和公众对整体风险评估过程的信心。SBRP包括四个生物科学项目、两个工程研究（项目5和6）和一个人口研究。毒理学研究包括：(1)确定内分泌干扰的机制；(2)研究复杂混合物的遗传毒性相互作用；(3)了解应激调节蛋白在细胞保护中的作用；项目5将开发化学干预技术，以补救与不同类别的超级基金污染物相关的风险。暴露评估和建模（项目6）研究将侧重于确定三个研究领域的主要污染物。来自环境评估的数据将用于模拟有毒化学品对野生动物或人类的运输和吸收，并估计与环境有关的剂量，以便在毒理学研究中进行测试（项目1-3）。项目6还将进行研究，以调查复杂混合物的生物利用度，并对修复受污染混合物的有前途的技术进行实地试验，并对修复受污染环境的有前途的技术进行实地试验。最后，项目7（环境污染、遗传因素和先天性畸形）将综合所有正在进行的研究结果，并在不同程度接触污染物的区域调查化学品引起的人类健康问题。这项研究将由服务核心、行政和培训核心，以及一个专注于公众和利益相关者社区的沟通和教育的外展核心来支持。