Neural and metabolic activity in vision and attention

视觉和注意力的神经和代谢活动

• 批准号: 6650701
• 负责人: JACK L GALLANT
• 金额: $ 18.52万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6650701
• 关键词: Macaca; action potentials; attention; behavior test; behavioral /social science research tag; biosensor device; brain electrical activity; brain imaging /visualization /scanning; charge coupled device camera; digital imaging; electrodes; electroencephalography; electrophysiology; fiber optics; fluorescent dye /probe; hemodynamics; metabolism; neurophysiology; oxygen transport; technology /technique development; ultrasound blood flow measurement; vision

DESCRIPTION (provided by applicant): Current methods for functional imaging of the human brain do not record neural activity directly, but instead measure metabolic activity consequent to neural activity. In contrast, much of our understanding of the function of the human brain comes from electrophysiological studies in animals that allow direct access to the neural signals underlying cognitive function. It is difficult to bridge the gap between neural and metabolic activity; their interrelationship is quite complex and depends on several biological and experimental factors. We propose to investigate the relationship between neural, metabolic and hemodynamic processes by use of a novel multispectral probe that allows simultaneous measurement of neural, metabolic and hemodynamic signals: spiking activity from multiple isolated single cells, local field potentials, EEG, local perfused 02 and local blood flow. This system will be used to quantify and characterize the relationship between neurophysiological and metabolic measures in an awake behaving animal model of human cognitive function. Subsequent experiments will use the multispectral probe to investigate neural, metabolic and hemodynamic signals in basic studies of visual function. A multispectral probe that is flexible and cheap enough to be integrated with daily neurophysiological recordings will enable a wide range of neurophysiologists to routinely make simultaneous measurements of neural, metabolic and hemodynamic activity. Information gained by the routine use of such a probe by the wider neurophysiological community could have dramatic effects on our interpretation and understanding of data acquired in neuroimaging experiments.

描述（由申请人提供）： 当前人脑功能成像的方法不会直接记录神经活动，而是测量与神经活动有关的代谢活性。相反，我们对人脑功能的大部分理解都来自动物的电生理研究，这些研究允许直接进入认知功能的神经信号。很难弥合神经和代谢活性之间的差距。他们的相互关系非常复杂，取决于几个生物学和实验因素。我们建议通过使用一种新型的多光谱探针来研究神经，代谢和血液动力学过程之间的关系，该探针允许同时测量神经，代谢和血液动力学信号：来自多个孤立的单个单个细胞，局部田间电位，EEG，EEG，EEG，EEG，局部灌注02和局部血液流的峰值活性。该系统将用于量化和表征神经生理学和代谢度量之间的关系，这是人类认知功能的醒目的动物模型。随后的实验将使用多光谱探针在视觉功能的基本研究中研究神经，代谢和血液动力学信号。一种柔性且便宜的多光谱探针，足以与每日神经生理记录整合在一起，这将使各种神经生理学家常规地同时测量神经，代谢和血液动力学活性。通过常规使用更广泛的神经生理学界对这种探测的常规使用所获得的信息可能会对我们对神经影像实验中获得的数据的解释和理解产生巨大影响。