Next Generation 3T MRI Scanner

下一代 3T MRI 扫描仪

• 批准号: 10415722
• 负责人: JACK L GALLANT
• 金额: $ 200万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-28 至 2024-06-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415722
• 关键词: Advisory Committees; Area; Basic Science; Brain; Brain imaging; California; Certification; Cognitive; Collaborations; Communities; Computer software; Contracts; Development; Diffusion; Engineering; Environment; Foundations; Funding; Grant; Head and neck structure; Hour; Human; Image; Laboratories; Magnetic Resonance Imaging; Maintenance; Manufacturer Name; Methods; Minor; Modernization; Outcome; Phase; Public Health; Request for Applications; Research; Research Personnel; Sales; San Francisco; Scanning; Signal Transduction; Slice; Specific qualifier value; Speed; System; Taxes; Training; United States National Institutes of Health; Universities; Update; arterial spin labeling; cost; experience; imaging facilities; improved; instrument; neuroimaging; next generation; operation; prisma; transmission process

1. PROJECT SUMMARY/ABSTRACT This application requests a Siemens Prisma 3 Tesla MRI system to be located in the Brain Imaging Center (BIC) at the University of California, Berkeley (UCB). The MRI user community at UCB currently consists of 12 major and 6 minor users on campus, at Lawrence Berkeley National Laboratory (LBNL), and at the University of California at San Francisco (UCSF). Together these researchers are supported by 36 current NIH grants and 15 other Federal and foundation grants that all depend on 3T MRI. Since 2008 this community has made use of a 3 Tesla Siemens Tim Trio MRI scanner that is located within and supported by the UCB BIC. However, this system is rapidly becoming obsolete. It no longer receives software or hardware updates from the manufacturer, and it cannot support some of the most modern neuroimaging methods. This request is for a modern MRI scanner that will enable application of advanced neuroimaging methods with significantly increased sensitivity relative to our current scanner. The specified instrument is a Magnetom Prisma 3 Tesla scanner with Tim XR gradients (maximum gradient amplitude of 80 mT/m with a 200 T/m/s slew rate). The system will have parallel transmission and phased-array receive coils: a 32 channel coil that will offer maximum SNR and continuity with the same coil on the Trio, and a 64 channel coil that will offer maximum coverage of the head and neck. A complete software suite will be available for advanced neuroimaging applications, such as simultaneous multi-slice, diffusion imaging and arterial spin labeling. The BIC at UCB provides a strong environment for supporting the requested instrument. The BIC co-Directors are Prof. Jack Gallant, a computational cognitive neuroscientist, and Prof. Chunlei Liu, an MRI physicist. BIC staff consists of Dr. Ben Inglis, an MRI physicist and two development engineers. These highly experienced staff will be directly responsible for scanner maintenance, upkeep and development, and for user training and certification. Operation and use of the instrument will be overseen by an independent advisory committee. UC Berkeley has committed support for the sales tax liability and minor renovations. The cost of the maintenance contract and support staff will be borne by hourly recharge billed through the BIC. Substantial NIH-funded research at UC Berkeley depends on the availability of a state-of-the-art 3T human MRI scanner. The requested instrument will improve scanning capacity in the areas of software, hardware, brain coverage, signal quality and comfort. The instrument will provide significantly improved signal quality and sensitivity over our current scanner, thereby improving all scientific outcomes. It will also facilitate collaboration between Berkeley investigators and those at other imaging facilities who are already using the Prisma scanner. Thus, the requested instrument will facilitate basic research and speed its application toward improving public health.

1.项目总结/摘要 该应用程序要求将Siemens Prisma 3 Tesla MRI系统置于脑成像中心 (BIC)在加州大学伯克利分校（UCB）。UCB的MRI用户社区目前由12个 在校园，劳伦斯伯克利国家实验室（LBNL）和大学的主要和6个次要用户 在旧金山弗朗西斯科（UCSF）的加州。这些研究人员共同得到了36个现有NIH赠款的支持 以及其他15个联邦和基金会的赠款，都依赖于3 T MRI。自2008年以来，该社区 使用位于UCB BIC内并由其支持的3 Tesla Siemens Tim Trio MRI扫描仪。 然而，这一制度正在迅速过时。它不再接收软件或硬件更新 制造商，它不能支持一些最现代的神经成像方法。 这项要求是一个现代化的MRI扫描仪，将使先进的神经成像方法的应用， 相对于我们现有的扫描仪，灵敏度显著提高。指定的仪器是磁共振仪 Prisma 3 Tesla扫描仪，带Tim XR梯度（最大梯度振幅为80 mT/m，200 T/m/s 转换速率）。该系统将具有并行发射和相控阵接收线圈：32通道线圈， 将提供最大的信噪比和连续性与相同的线圈在三重奏，和一个64通道线圈，将提供 最大限度地覆盖头部和颈部。一个完整的软件套件将提供先进的 神经成像应用，如同步多切片、扩散成像和动脉自旋标记。 UCB的BIC为支持所要求的工具提供了强大的环境。BIC联合董事 是Jack Gallant教授，计算认知神经科学家，和Chunlei Liu教授，MRI物理学家。BIC 工作人员包括本英格利斯博士，MRI物理学家和两名开发工程师。这些经验丰富的 工作人员将直接负责扫描仪的维护、保养和开发以及用户培训， 认证该文书的运作和使用将由一个独立的咨询委员会监督。UC 伯克利已承诺支持销售税的责任和小的装修。维持费用 合同和支持人员的费用将通过BIC按小时收费来承担。 加州大学伯克利分校的大量NIH资助的研究取决于最先进的3 T人类的可用性 核磁共振扫描仪。所要求的仪器将提高软件、硬件、 大脑覆盖率、信号质量和舒适度。该仪器将提供显著改善的信号质量， 灵敏度超过我们目前的扫描仪，从而改善所有的科学成果。它还将促进合作 伯克利研究人员和其他成像机构已经使用棱镜扫描仪的人员之间进行了合作。 因此，所要求的工具将促进基础研究，并加快其应用，以改善公众 健康