Next Generation 3T MRI Scanner

下一代 3T MRI 扫描仪

• 批准号: 10415722
• 负责人: JACK L GALLANT
• 金额: $ 200万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-28 至 2024-06-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415722
• 关键词: Advisory Committees; Area; Basic Science; Brain; Brain imaging; California; Certification; Cognitive; Collaborations; Communities; Computer software; Contracts; Development; Diffusion; Engineering; Environment; Foundations; Funding; Grant; Head and neck structure; Hour; Human; Image; Laboratories; Magnetic Resonance Imaging; Maintenance; Manufacturer Name; Methods; Minor; Modernization; Outcome; Phase; Public Health; Request for Applications; Research; Research Personnel; Sales; San Francisco; Scanning; Signal Transduction; Slice; Specific qualifier value; Speed; System; Taxes; Training; United States National Institutes of Health; Universities; Update; arterial spin labeling; cost; experience; imaging facilities; improved; instrument; neuroimaging; next generation; operation; prisma; transmission process

1. PROJECT SUMMARY/ABSTRACT This application requests a Siemens Prisma 3 Tesla MRI system to be located in the Brain Imaging Center (BIC) at the University of California, Berkeley (UCB). The MRI user community at UCB currently consists of 12 major and 6 minor users on campus, at Lawrence Berkeley National Laboratory (LBNL), and at the University of California at San Francisco (UCSF). Together these researchers are supported by 36 current NIH grants and 15 other Federal and foundation grants that all depend on 3T MRI. Since 2008 this community has made use of a 3 Tesla Siemens Tim Trio MRI scanner that is located within and supported by the UCB BIC. However, this system is rapidly becoming obsolete. It no longer receives software or hardware updates from the manufacturer, and it cannot support some of the most modern neuroimaging methods. This request is for a modern MRI scanner that will enable application of advanced neuroimaging methods with significantly increased sensitivity relative to our current scanner. The specified instrument is a Magnetom Prisma 3 Tesla scanner with Tim XR gradients (maximum gradient amplitude of 80 mT/m with a 200 T/m/s slew rate). The system will have parallel transmission and phased-array receive coils: a 32 channel coil that will offer maximum SNR and continuity with the same coil on the Trio, and a 64 channel coil that will offer maximum coverage of the head and neck. A complete software suite will be available for advanced neuroimaging applications, such as simultaneous multi-slice, diffusion imaging and arterial spin labeling. The BIC at UCB provides a strong environment for supporting the requested instrument. The BIC co-Directors are Prof. Jack Gallant, a computational cognitive neuroscientist, and Prof. Chunlei Liu, an MRI physicist. BIC staff consists of Dr. Ben Inglis, an MRI physicist and two development engineers. These highly experienced staff will be directly responsible for scanner maintenance, upkeep and development, and for user training and certification. Operation and use of the instrument will be overseen by an independent advisory committee. UC Berkeley has committed support for the sales tax liability and minor renovations. The cost of the maintenance contract and support staff will be borne by hourly recharge billed through the BIC. Substantial NIH-funded research at UC Berkeley depends on the availability of a state-of-the-art 3T human MRI scanner. The requested instrument will improve scanning capacity in the areas of software, hardware, brain coverage, signal quality and comfort. The instrument will provide significantly improved signal quality and sensitivity over our current scanner, thereby improving all scientific outcomes. It will also facilitate collaboration between Berkeley investigators and those at other imaging facilities who are already using the Prisma scanner. Thus, the requested instrument will facilitate basic research and speed its application toward improving public health.

1.项目总结/摘要 此应用程序要求将西门子Prisma 3特斯拉磁共振系统安装在脑成像中心 (BIC)，加州大学伯克利分校(UCB)。UCB的MRI用户社区目前有12个 校园、劳伦斯·伯克利国家实验室(LBNL)和大学的主要用户和6名次要用户 加州大学旧金山分校(UCSF)。这些研究人员总共得到了36项目前NIH拨款的支持 以及其他15项联邦和基金会拨款，它们都依赖于3T核磁共振。自2008年以来，这个社区已经取得了 使用位于UCB BIC内部并由其支持的3特斯拉西门子TIM Trio磁共振扫描仪。 然而，这个系统正在迅速变得过时。它不再从以下地址接收软件或硬件更新 制造商，它不能支持一些最现代的神经成像方法。 这一要求是为了一种现代核磁共振扫描仪，它将能够应用先进的神经成像方法 与我们目前的扫描仪相比，敏感度显著提高。指定的仪器是磁力机 带TIM XR梯度的Prisma 3特斯拉扫描仪(最大梯度幅度80mT/m，200T/m/S 转换率)。该系统将有并行传输和相控阵接收线圈：一个32通道线圈， 将提供最大的SNR和连续性，与三重奏上相同的线圈，和一个通道线圈，将提供 最大限度地覆盖头部和颈部。高级版将提供完整的软件套件 神经成像应用，如多层同时成像、扩散成像和动脉自旋标记。 联合银行的BIC为支持所要求的文书提供了强有力的环境。BIC联席董事 分别是计算认知神经学家杰克·加兰特教授和核磁共振物理学家刘春雷教授。比克 工作人员包括本·英格利斯博士，一名核磁共振物理学家和两名开发工程师。这些经验丰富的人 工作人员将直接负责扫描仪的维护、维护和开发，以及用户培训和 认证。该文书的运作和使用将由一个独立的咨询委员会监督。加州大学 伯克利已承诺支持销售税负担和小规模翻新。维护费 合同和支持人员将通过BIC支付每小时充值费用。 加州大学伯克利分校由NIH资助的大量研究取决于是否有最先进的3T人类 核磁共振扫描仪。所要求的仪器将在软件、硬件、 大脑覆盖率、信号质量和舒适性。该仪器将提供显著改善的信号质量和 比我们目前的扫描仪更灵敏，从而改善了所有科学成果。它还将促进合作 伯克利大学的调查人员和其他成像设施中已经在使用棱镜扫描仪的人之间的关系。 因此，所要求的仪器将促进基础研究，并加快其应用，以改善公众 健康。