权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Piezoelectric polymer nanostructures for tissue growth stimulation.

用于刺激组织生长的压电聚合物纳米结构。

基本信息

批准号：
2108505
负责人：
金额：
--
依托单位：
University of Cambridge
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2018
资助国家：
英国
起止时间：
2018 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2108505
关键词：
Piezoelectric polymer nanostructures tissue growth

项目摘要

Piezoelectric polymer nanostructures for tissue growth stimulation.Description: Cell stimulation can occur via three main methods; chemical, mechanical and electronic. This project will explore the latter two techniques via the medium of piezoelectric nanowires, which can be utilised to produce mechanical stimulation via the application of an electric field. In addition the application of the electric field itself is expected to influence cell growth and behaviour. It is eventually hoped that sufficient control of tissue stimulation may be achieved to create tissue interfacing devices, to replace less biocompatible synthetic devices.Key Objectives: The project aims to identify and develop a suitable biocompatible piezoelectric material whose properties can be controlled at the nanoscale through process control. These will then be integrated with electrical detection capability using an aerosol-jet printing technique that will provide micron-level electrical access to the piezoelectric nanostructures, thus resulting in a bio-electromechanical interfacing platform. This platform will then be deployed to study and control the behaviour of a variety of different cell types, with efforts towards targeted cell and tissue growth and stimulation.Novel Science: The ability to dynamically control the electromechanical environment of biological material at the cellular level will shed new light on the mechanisms determining cell signalling and behaviour. Importantly, this project will provide a powerful tool to manipulate the local environment of cells using external electric fields that could lead to advances in directed tissue growth and regeneration.

用于组织生长刺激的压电聚合物纳米结构。描述：细胞刺激可以通过三种主要方法发生;化学，机械和电子。该项目将通过压电纳米线介质探索后两种技术，压电纳米线可用于通过施加电场产生机械刺激。此外，电场本身的应用预计会影响细胞生长和行为。最终希望能够实现对组织刺激的充分控制，以创建组织界面装置，以取代生物相容性较差的合成装置。主要目标：该项目旨在识别和开发一种合适的生物相容性压电材料，其性能可以通过过程控制在纳米级进行控制。然后，这些将使用气溶胶喷射印刷技术与电检测能力集成，该技术将提供对压电纳米结构的微米级电访问，从而产生生物机电接口平台。该平台将用于研究和控制各种不同细胞类型的行为，努力实现靶细胞和组织的生长和刺激。新科学：在细胞水平上动态控制生物材料机电环境的能力将为决定细胞信号和行为的机制提供新的思路。重要的是，该项目将提供一个强大的工具，使用外部电场来操纵细胞的局部环境，这可能导致定向组织生长和再生的进步。