EMERGENCY POWER AND QUARANTINE CAGING

应急电源和隔离笼

• 批准号: 6602217
• 负责人: HAROLD F STILLS
• 金额: $ 10.59万
• 依托单位: WRIGHT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6602217
• 关键词: animal care; animal colony; biomedical device power system; building /facility design /renovation; isolation /quarantine; laboratory mouse

DESCRIPTION (provided by applicant): This alteration and renovation project has two primary specific aims. The first aim is to install a diesel emergency electrical generator to provide electrical power to the LAR facility during power outages. The continuous operation of lighting; heating, ventilation, and air-conditioning equipment is critical to providing a stable environment for laboratory animals housed and used in biomedical research. Electrical power is also critical to many of the PHS-funded projects using animals at WSU including those involving retinal degeneration, hyperbaric environmental conditions, and surgical procedures. Electrical failure would result in a catastrophic loss of these vital functions resulting in variations or the invalidation of biomedical research results along with potential animal illness and death. Because of the animal facility's basement location, the effect of electrical failure is compounded by the resulting lack of service elevator function, severely hampering animal removal and relocation during emergencies. For these reasons, the Guide for the Care and Use of Laboratory Animals states, "in the event of power failure, an alternative or emergency power supply should be available to maintain critical services... ." The second aim is to increase the LAR's capability to receive and quarantine mice from other institutions. Quarantine and isolation of incoming animals is a critical component of the veterinary preventive medical program to prevent the introduction and spread of infectious diseases throughout the facility. The steadily increasing level of externally funded biomedical research at WSU along with the increased utilization of genetically modified mice from various research centers has dramatically increased the need for animal quarantine and isolation. This has resulted in a number of animal rooms being occupied by a small number of animals undergoing quarantine while other investigators, including PHS-funded investigators, are unable to order animals due to the unavailability of animal rooms. The purchase of a negative pressure high efficiency particulate air (HEPA)-filtered animal rack system for mice and a biological safety cabinet for animal manipulations will permit quarantine of incoming mice from multiple institutions in a single animal room, instead of many, freeing additional animal rooms for biomedical research efforts.

描述（由申请人提供）： 这一改造和翻新项目有两个主要具体目标。 第一个目标是安装一台柴油应急发电机，以便在停电时为LAR设施提供电力。 照明、供暖、通风和空调设备的连续运行对于为生物医学研究中饲养和使用的实验室动物提供稳定的环境至关重要。 电力对于华盛顿州立大学许多使用动物的PHS资助项目也至关重要，包括涉及视网膜变性、高压环境条件和外科手术的项目。 电气故障将导致这些重要功能的灾难性丧失，导致生物医学研究结果的变化或失效沿着潜在的动物疾病和死亡。 由于动物设施位于地下室，电力故障的影响因服务电梯功能的缺乏而加剧，严重阻碍了紧急情况下动物的迁移和重新安置。 由于这些原因，《实验动物护理和使用指南》规定，“在发生电源故障时，应提供替代或应急电源，以维持关键服务. .“第二个目的是加强实验室接收和检疫来自其他机构的老鼠的能力。 检疫和隔离传入动物是兽医预防性医疗计划的关键组成部分，以防止传染病在整个设施中的引入和传播。 在WSU，外部资助的生物医学研究水平稳步提高，沿着来自各个研究中心的转基因小鼠的利用率增加，这大大增加了对动物检疫和隔离的需求。 这导致一些动物房被少数接受检疫的动物占用，而其他研究者，包括PHS资助的研究者，由于没有动物房而无法订购动物。 购买用于小鼠的负压高效微粒空气（HEPA）过滤动物架系统和用于动物操作的生物安全柜将允许在单个动物室而不是许多动物室中隔离来自多个机构的传入小鼠，从而释放更多的动物室用于生物医学研究工作。