Enhancement of the Biological-Pharmaceutical Animal Facility

生物医药动物设施的强化

• 批准号: 8185225
• 负责人: HAROLD F STILLS
• 金额: $ 48.45万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8185225
• 关键词: Academic Medical Centers; Allergens; Ambulatory Care Facilities; Animal Housing; Animals; Area; Biological; Biomedical Research; Environment; Floor; Funding; House mice; Housing; Infectious Agent; Instruction; Kentucky; Laboratories; Laboratory Animals; Laboratory Research; Malignant Neoplasms; Mus; Patients; Pharmacologic Substance; Pharmacy facility; Procedures; Process; Recruitment Activity; Research; Research Personnel; Rodent; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; University Hospitals; animal facility; animal resource; biosecurity; college; improved; research facility

DESCRIPTION (provided by applicant): The University of Kentucky (UK) Division of Laboratory Animal Resources (DLAR) requests $484,475 to purchase individually ventilated caging (IVC) and animal transfer stations. This proposal will equip 3 rooms in a suite of 4 presently unoccupied rodent housing rooms with shared procedure rooms and provide desperately needed caging capacity in the newly constructed Biological-Pharmaceutical (Bio-Pharm) Building animal facility. The Bio-Pharm facility is a modern research facility and the largest academic and research building in the State of Kentucky. The facility was constructed and the lower four levels (basement- animal facility and NMR facility, floors 1&2-academic instruction, floor 3- research) outfitted with state funding. The fourth and fifth research laboratory floors are presently being completed with university funding with an anticipated March 2011 occupancy. These two floors will support an increased emphasis on research in the College of Pharmacy and expansion of cancer related research at the university. Additional successful investigators are presently being recruited for these areas of emphasis. The requested caging will maximize potential housing capabilities and provide optimal animal housing environments while reducing labor requirements for these additional investigators. The additional caging capability will also permit NIH-funded UK investigators to move their mouse housing from the nearby Lexington Veterans Administration (Lexington VA) facility to UK facilities that are much closer to their laboratories. This relocation will reduce the transport of animals from the Lexington VA to UK research laboratories, a process that jeopardizes animal biosecurity and exposes patients at the Lexington VA Hospital, the UK A. B. Chandler Medical Center, and the UK Clinic (outpatient facility) to rodent allergens and potentially infectious agents. The acquisition of the requested caging will permit the university to maximize use of the newly constructed animal facility and improve the ability of the university to support NIH-funded investigators using mice in biomedical research.

描述（由申请人提供）：肯塔基大学（英国）实验动物资源部门（DLAR）申请484,475美元用于购买单独通风笼（IVC）和动物转移站。该方案将为目前空置的4个啮齿动物住房房间中的3个房间配备共享的手术室，并在新建的生物制药大楼动物设施中提供急需的笼子容量。生物制药设施是一个现代化的研究设施，也是肯塔基州最大的学术和研究建筑。该设施的建造和较低的四层（地下室-动物设施和核磁共振设施，1层和2层-学术教学，3层-研究）配备了国家资助。第四层和第五层研究实验室目前正在大学资助下完工，预计2011年3月投入使用。这两层楼将支持药学院的研究重点和大学癌症相关研究的扩展。目前正在为这些重点领域征聘更多成功的调查人员。所要求的笼子将最大限度地提高潜在的住房能力，并提供最佳的动物住房环境，同时减少这些额外调查员的劳动力需求。额外的笼子能力也将允许美国国立卫生研究院资助的英国研究人员将他们的老鼠住房从附近的列克星敦退伍军人管理局（列克星敦VA）设施转移到离他们实验室更近的英国设施。这次搬迁将减少从列克星敦退伍军人医院到英国研究实验室的动物运输，这一过程危及动物生物安全，并使列克星敦退伍军人医院、英国a.b.钱德勒医疗中心和英国诊所（门诊设施）的病人暴露于啮齿动物过敏原和潜在的传染性病原体。获得要求的笼子将允许大学最大限度地利用新建的动物设施，并提高大学支持nih资助的研究人员在生物医学研究中使用老鼠的能力。