Alcohol and Multimodal Brain Imaging

描述（由申请人提供）： 尽管酒精中毒会影响多个层面的功能 神经轴，在复杂性或新颖性增加的情况下的执行能力 受到特别干扰。 酒精可能会干扰认知评估 新颖的线索和抑制冲动反应的能力，有助于 对社会具有重要意义的危害、冲动控制能力差和酒精依赖。 拟议研究的总体目标是确定空间和时间 参与新奇事物处理的大脑回路的特征 反应去抑制并确定其与剂量相关的敏感性 酒精的急性影响。 多式联运方法整合了各自的 互补神经影像学方法的优点。 功能性磁性 将使用磁共振成像（fMRI）来确定 酒精引起的变化正在发生。 出色的时间分辨率 磁图（MEG）和脑电图（EEG）将阐明 这些异常。 此外，候选人的初步工作表明 交感神经兴奋的同时测量对于解释至关重要 酒精对新奇事物综合反应的影响。 功能性 调查将集中于酒精对身体的严重破坏性影响 新奇处理、抑制控制的分布式神经系统 和唤醒。 健康受试者在参与时将作为自己的对照 酒精（低剂量和高剂量）和安慰剂条件下的两个不同水平 任务复杂性。 为了实现这些目标，候选人寻求 1) fMRI 测量和分析技术的培训，包括 事件相关的 FMRI 设计、皮质重建和多模态集成 2）酒精和药物使用和依赖性的精神药理学。 的 综合培训和研究计划将使候选人能够 独立应用这些多模态成像工具来提高我们的知识 酒精对大脑的影响。

DESCRIPTION (provided by applicant): Although alcohol intoxication affects functioning at multiple levels of the neuraxis, executive abilities in situations of increased complexity or novelty are especially disrupted. Alcohol may interfere with cognitive assessment of novel cues and the capacity to inhibit impulsive responses, contributing to the societally-important hazards, poor impulse control and alcohol dependence. The overall goal of the proposed research is to identify spatial and temporal characteristics of the brain circuits involved in novelty processing and response disinhibition and to determine their dose-related sensitivity to the acute effects of alcohol. A multimodal approach integrates respective advantages of complementary neuroimaging methods. Functional magnetic resonance imaging (fMRI) will be used in order to determine where the alcohol-induced, changes are occurring. Excellent temporal resolution of magneto- (MEG) and electro-encephalography (EEG) will elucidate the timing of these abnormalities. Furthermore, the candidate's preliminary work suggests that concurrent measures of sympathetic arousal are crucial for interpreting the effects of alcohol upon the integrated response to novelty. Functional investigations will focus on the acute disruptive effects of alcohol on the distributed neural systems underlying novelty processing, inhibitory control and arousal. Healthy subjects will serve as their own controls as they participate in alcohol (low and high dose) and placebo conditions at two different levels of task complexity. In order to achieve these goals, the candidate seeks training in 1) fMRI measurement and analytic techniques including event-related FMRI design, cortical reconstruction and multimodal integration and 2) psychopharmacology of alcohol and drug use and dependence. The integrated training and research program will enable the candidate to independently apply these multimodal imaging tools to advance our knowledge of alcohol's effects on the brain.