Alcohol and Multimodal Brain Imaging

酒精和多模式脑成像

• 批准号: 6620467
• 负责人: KSENIJA MARINKOVIC
• 金额: $ 15.67万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6620467
• 关键词: alcoholism /alcohol abuse; arousal; attention; behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; clinical research; dosage; electroencephalography; ethanol; functional magnetic resonance imaging; human middle age (35-64); human subject; impulsive behavior; magnetoencephalography; neural information processing; neurotoxicology; personality; postdoctoral investigator; psychic activity level; psychomotor function; psychopharmacology; stimulus /response; substance abuse related behavior; young adult human (21-34)

DESCRIPTION (provided by applicant): Although alcohol intoxication affects functioning at multiple levels of the neuraxis, executive abilities in situations of increased complexity or novelty are especially disrupted. Alcohol may interfere with cognitive assessment of novel cues and the capacity to inhibit impulsive responses, contributing to the societally-important hazards, poor impulse control and alcohol dependence. The overall goal of the proposed research is to identify spatial and temporal characteristics of the brain circuits involved in novelty processing and response disinhibition and to determine their dose-related sensitivity to the acute effects of alcohol. A multimodal approach integrates respective advantages of complementary neuroimaging methods. Functional magnetic resonance imaging (fMRI) will be used in order to determine where the alcohol-induced, changes are occurring. Excellent temporal resolution of magneto- (MEG) and electro-encephalography (EEG) will elucidate the timing of these abnormalities. Furthermore, the candidate's preliminary work suggests that concurrent measures of sympathetic arousal are crucial for interpreting the effects of alcohol upon the integrated response to novelty. Functional investigations will focus on the acute disruptive effects of alcohol on the distributed neural systems underlying novelty processing, inhibitory control and arousal. Healthy subjects will serve as their own controls as they participate in alcohol (low and high dose) and placebo conditions at two different levels of task complexity. In order to achieve these goals, the candidate seeks training in 1) fMRI measurement and analytic techniques including event-related FMRI design, cortical reconstruction and multimodal integration and 2) psychopharmacology of alcohol and drug use and dependence. The integrated training and research program will enable the candidate to independently apply these multimodal imaging tools to advance our knowledge of alcohol's effects on the brain.

描述（由申请人提供）： 虽然酒精中毒会影响多个层面的功能， 在复杂性或新奇性增加的情况下的执行能力 尤其受到干扰。 酒精可能会干扰认知评估 新的线索和抑制冲动反应的能力，有助于 对社会有重要影响的危险，冲动控制不良和酒精依赖。 本研究的总体目标是确定空间和时间 参与新奇处理的大脑回路的特征， 反应解除抑制，并确定其剂量相关的敏感性， 酒精的急性效应。 多模式方法整合了各自的 互补神经影像学方法的优势。 功能磁 将使用核磁共振成像（fMRI）来确定 酒精引起的变化正在发生。 出色的时间分辨率， 磁（MEG）和脑电图（EEG）将阐明 这些异常。 此外，候选人的初步工作表明， 交感神经兴奋的同步测量对于解释 酒精对新奇综合反应的影响。 功能 调查将集中在酒精对大脑的急性破坏性影响上。 新奇处理的分布式神经系统，抑制控制 和兴奋 健康受试者将作为他们自己的对照，因为他们参加了 酒精（低剂量和高剂量）和安慰剂条件下的两种不同水平的 任务复杂度 为了实现这些目标，候选人寻求 1）fMRI测量和分析技术培训，包括 事件相关功能磁共振成像设计、皮质重建和多模态整合 2）酒精和药物使用和依赖的精神药理学。 的 综合培训和研究计划将使候选人能够 独立地应用这些多模态成像工具， 酒精对大脑的影响