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DNA Damage and Cellular Defense

DNA 损伤和细胞防御

基本信息

批准号：
7529422
负责人：
ALAN J TOWNSEND
金额：
$ 1.14万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-11 至 2012-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7529422
关键词：
Accounting Acridines Alkylating Agents Alkylation Alternative Medicine Animal Cancer Model Animals Antioxidants Apoptosis Apoptotic Applications Grants Area Award Basic Science Biochemistry Biological Assay Biology Bypass Cancer Center Cancer Etiology Carcinogens Carrier Proteins Categories Cell Cycle Cell Death Cells Cervical Intraepithelial Neoplasia Chemical Agents Chemicals Chemistry Chemoprevention Chemopreventive Agent Class Clinical Research Clinical Trials Collaborations Comprehensive Cancer Center of Wake Forest University Cultured Cells Curcumin Cytotoxic Chemotherapy Cytotoxic agent DNA DNA Adducts DNA Damage DNA Repair DNA Repair Pathway DNA Sequence DNA biosynthesis DNA lesion DNA-Directed DNA Polymerase Defect Defense Mechanisms Development Diagnosis Dithiolthione Drug Metabolic Detoxication Drug resistance Early Diagnosis Enzyme Induction Enzymes Evolution Experimental Genetics Exposure to Faculty Failure Ferritin Foundations Funding Future Genes Genetic Genetic Counseling Genomics Germ-Line Mutation Glutathione Glutathione S-Transferase Goals Grant Growth Human Hydroxyl Radical Individual Investigation Ionizing radiation Iron Iron Chelation Knowledge Learning Lesion Life Style Link Maintenance Malignant Neoplasms Malignant neoplasm of lung Mammalian Cell Mediating Membrane Metabolic Activation Mismatch Repair Modification Molecular Structure Mutagenesis Mutagens Mutation NADPH Oxidase Nature Numbers Oncogenic Oxidants Oxidation-Reduction Oxidative Stress Pathologic Mutagenesis Pathway interactions Peer Review Pharmaceutical Preparations Phase Phenotype Pilot Projects Platinum Compounds Play Population Predisposition Prevention Process Production Productivity Prognostic Marker Proteins Publications Radiation Radiation therapy Radiation-Sensitizing Agents Radio Range Rapid Access to Intervention Development Reactive Oxygen Species Recruitment Activity Recurrence Regulation Regulator Genes Replication Error Research Research Personnel Resistance Resolvase Role Scientist Services Signal Transduction Single-Stranded DNA Solutions Source Specificity Subgroup Sulfur Sulindac Testing Therapeutic Topical application Toxic effect Translating Translational Research Translations Water Work Xenobiotics aging population analog anticancer research base brain irradiation injury caffeic acid phenethyl ester cancer cell cancer diagnosis cancer prevention cancer risk cancer therapy carcinogenesis cell growth cell injury chemical carcinogen chemotherapeutic agent chemotherapy cysteinesulfenic acid cytotoxic cytotoxicity demographics drug development drug efficacy environmental carcinogenesis expression cloning human study improved innovation interest killings macromolecule member neoplastic cell novel novel therapeutics oltipraz prenatal prevent programs repaired response sensor spleen exonuclease three dimensional structure trend tumor

项目摘要

The DNA Damage and Cellular Defense (DDCD) Program is a highly interactive group of 23 members of the Comprehensive Cancer Center of Wake Forest University, representing 7 Departments and Sections. The overall scientific goal within the DDCD Program is to understand the mechanisms and processes whereby cells sustain - or alternatively, mitigate by prevention or repair - damage to DNA or other critical macromolecular structures. The Program encourages translational strategies that employ either novel chemotherapeutics or chemopreventive agents. Research focus in the DDCD program can be represented within two thematic aims: 1) To determine mechanisms of damage to DNA and other macromolecules by chemical agents or radiation, and how this damage results in detrimental carcinogenic effects or beneficial anticancer effects (in chemc¿ and radiation therapy); and 2) To identify cellular defense mechanisms that function in prevention of carcinogenesis and modulation of tumor sensitivity to cytotoxic chemotherapy and radiation therapy. The DDCD Program has a strong funding and productivity record. Total NCI and other peer-reviewed funding has more than tripled from $1.81M to $6.28M since the previous review. Members are highly interactive, with 54 of 203 intra-programmatic publications (26.6%) and 18 inter-programmatic publications (8.9%). Also, a number of grant co-investigatorships have resulted from both established and new collaborations (66.7% of grants have a formal collaboration with another CCCWFU member). Members rely on CCCWFU core lab services in support of their research, and have made efficient use of CCCWFU pilot funding: many pilot projects have matured into grant applications and some into funded grants. The Program meets in a biweekly seminar format, and holds an annual retreat. Three new monthly interest subgroups have begun, one on signaling functions of antioxidant enzymes, a second on DNA damage, repair, and mutagenesis, and a third group of clinicians and basic scientists to develop new translational research collaborations in lung cancer.

DNA损伤和细胞防御（DDCD）计划是一个由23名成员组成的高度互动的小组，维克森林大学综合癌症中心，代表7个部门和部门。的 DDCD计划的总体科学目标是了解机制和过程，细胞维持-或替代地，通过预防或修复来减轻-对DNA或其他关键细胞的损伤。大分子结构该计划鼓励翻译策略，采用或小说化学治疗剂或化学预防剂。DDCD计划中的研究重点可以代表在两个主题目标：1）确定DNA和其他大分子的损伤机制，化学试剂或辐射，以及这种损害如何导致有害的致癌作用或有益的抗癌作用（在化学和放射治疗）;和2）确定细胞防御机制，在预防致癌作用和调节肿瘤对细胞毒性化疗的敏感性方面的作用，放射治疗DDCD计划拥有强大的资金和生产力记录。NCI和其他共计自上次审查以来，同行审查的资金从181万美元增加到628万美元，增加了两倍多。成员互动性强，203份计划内出版物中有54份（26.6%）和18份计划间出版物出版物（8.9%）。此外，一些赠款共同赞助机构已成立，新的合作（66.7%的赠款与另一个CCCWFU成员有正式合作）。成员依靠CCCWFU核心实验室服务来支持他们的研究，并有效地利用CCCWFU 试点供资：许多试点项目已发展到赠款申请阶段，有些项目已成为有资金支持的赠款。的该计划以双周研讨会的形式举行，并举行年度务虚会。三个新的月息小组已经开始，一个关于抗氧化酶的信号功能，第二个关于DNA损伤，修复和诱变，以及第三组临床医生和基础科学家开发新的翻译肺癌的研究合作。