Human Functional Brain Anatomy

人类功能性大脑解剖学

• 批准号: 6529696
• 负责人: GREGORY MCCARTHY
• 金额: $ 141.41万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529696
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; functional magnetic resonance imaging; neuroanatomy; neuropsychology

DESCRIPTION (provided by applicant) This Program Project will investigate the functional neuroanatomy of the human brain using high-field functional magnetic resonance imaging (functional MRI), electrophysiology, and behavior. The four scientific projects are strongly linked by their focus on the relationship between brain and behavior. The projects are organized into a logical progression from sensory processing through response selection. Project 1 considers the relationship between performance in elemental visual psychophysical tasks and the quantitative structural anatomy of primary visual cortex (Vl). This project is technically challenging and depends upon high-resolution fMRI-based retinotopic mapping to discriminate V1 from other visual areas. Project 2 also focuses upon early visual processing, however its emphasis is upon changes in processing as a function of directed attention. Project 3 builds directly upon Project 2 by investigating the domain specificity (space or feature) of attended visual attributes that must be maintained in a transient memory store for later processing. Project 3 also investigates the role of response processing and sequential expectancies in prefrontal cortex. Project 4 will investigate the manner in attention is attracted automatically or reflexively by novel and/or distracting stimuli. The scientific projects are supported by three Cores. Core A is administrative. Core B will develop methods in high-field functional MRI designed to improve the functional resolution of brain imaging. This core will develop and implement methods to improve the specificity of the MR signal to brain parenchyma, to recover signal lost to large scale susceptibility artifacts in ventral frontal and medial temporal regions, and to improve the spatial and temporal resolution of BOLD contrast. Core C will develop and implement methods for experimental control, physiological monitoring, and analysis of structural and functional image data.

描述(由申请人提供) 该计划项目将研究人类的功能神经解剖学 使用高场功能磁共振成像(功能MRI)的大脑， 电生理学和行为学。这四个科学项目是强有力的 他们把注意力集中在大脑和行为之间的关系上。这个 项目被组织成一个从感觉加工到逻辑进程的过程 通过回答选择。项目1考虑的是 在基本视觉心理物理任务中的表现和量化 初级视皮层(Vl)的结构解剖。从技术上讲，这个项目 具有挑战性，并依赖于基于高分辨率fMRI的视网膜定位 将V1与其他视觉区域区分开来。项目2还侧重于早期 视觉处理，然而，它的重点是处理的变化作为一个 定向注意的功能。项目3通过以下方式直接在项目2上构建 研究被关注视觉的领域特异性(空间或特征) 必须在临时内存存储中维护以备以后使用的属性 正在处理。项目3还调查了响应处理的作用和 前额叶皮质的连续预期。项目4将调查 注意的方式被新奇和/或 令人分心的刺激。这些科学项目由三个核心支持。堆芯 A是行政性的。Core B将开发高场功能MRI的方法 旨在提高脑成像的功能分辨率。这个核心将 开发和实施方法以提高磁共振信号的特异性 脑实质，以恢复因大规模敏感性而丢失的信号 前额腹侧和内侧颞区的伪影，并改善 空间和时间分辨率的大胆对比。核心C将开发和 实施实验控制、生理监测和 结构和功能图像数据的分析。