Human Functional Brain Anatomy

人类功能性大脑解剖学

• 批准号: 6647604
• 负责人: GREGORY MCCARTHY
• 金额: $ 139.74万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6647604
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; functional magnetic resonance imaging; neuroanatomy; neuropsychology

DESCRIPTION (provided by applicant) This Program Project will investigate the functional neuroanatomy of the human brain using high-field functional magnetic resonance imaging (functional MRI), electrophysiology, and behavior. The four scientific projects are strongly linked by their focus on the relationship between brain and behavior. The projects are organized into a logical progression from sensory processing through response selection. Project 1 considers the relationship between performance in elemental visual psychophysical tasks and the quantitative structural anatomy of primary visual cortex (Vl). This project is technically challenging and depends upon high-resolution fMRI-based retinotopic mapping to discriminate V1 from other visual areas. Project 2 also focuses upon early visual processing, however its emphasis is upon changes in processing as a function of directed attention. Project 3 builds directly upon Project 2 by investigating the domain specificity (space or feature) of attended visual attributes that must be maintained in a transient memory store for later processing. Project 3 also investigates the role of response processing and sequential expectancies in prefrontal cortex. Project 4 will investigate the manner in attention is attracted automatically or reflexively by novel and/or distracting stimuli. The scientific projects are supported by three Cores. Core A is administrative. Core B will develop methods in high-field functional MRI designed to improve the functional resolution of brain imaging. This core will develop and implement methods to improve the specificity of the MR signal to brain parenchyma, to recover signal lost to large scale susceptibility artifacts in ventral frontal and medial temporal regions, and to improve the spatial and temporal resolution of BOLD contrast. Core C will develop and implement methods for experimental control, physiological monitoring, and analysis of structural and functional image data.

描述（由申请人提供） 本项目将研究人类的功能性神经解剖学 大脑使用高场功能性磁共振成像（功能性MRI）， 电生理学和行为学。这四个科学项目是强有力的 通过他们对大脑和行为之间关系的关注而联系起来。的 项目被组织成一个逻辑的进程，从感官处理 通过响应选择。项目1考虑了 在基本视觉心理物理任务中的表现和定量 初级视皮层（V1）结构解剖。该项目在技术上 具有挑战性，并依赖于高分辨率fMRI为基础的视网膜定位映射， 将V1与其他视觉区域区分开来。项目2也关注早期 视觉处理，然而，它的重点是在处理的变化， 集中注意力的功能。项目3直接建立在项目2的基础上， 调查领域特异性（空间或特征）的关注视觉 必须保存在临时存储器中以供以后使用的属性 处理.项目3还研究了响应处理的作用， 前额叶皮层的连续预期项目4将调查 注意力的方式是自动或反射性地被小说和/或 分心的刺激这些科学项目得到三个核心的支持。核心 A是行政。核心B将开发高场功能性MRI方法 旨在提高大脑成像的功能分辨率。核心将 开发和实施方法，以提高MR信号的特异性， 脑实质，以恢复大范围敏感性丢失的信号 在腹侧额叶和内侧颞区的伪影，并改善 BOLD对比度的空间和时间分辨率。核心C将开发和 实施实验控制、生理监测和 分析结构和功能图像数据。