IMPROVING RECOVERY AFTER STROKE

改善中风后的恢复

• 批准号: 6563301
• 负责人: Pamela W. Duncan
• 金额: $ 23.07万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-15 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6563301
• 关键词: clinical research; clinical trials; comorbidity; depression; exercise; functional ability; gait; human old age (65+); human subject; human therapy evaluation; neuromuscular system; outcomes research; person with disability; rehabilitation; stroke

Description: A major focus of this OAIC is to conduct IDSs designed to improve the function and independence of older Americans recovering from stroke. The primary goal of this project is to determine if a physiologically based 12-week program of therapeutic exercise which targets upper and lower extremity strength, balance, endurance, and upper extremity use can improve key impairments and functional performance (motor function, balance, endurance, gait and upper extremity function) in individuals following a stroke. The secondary goals are to determine the clinical significance of the intervention and examine the mechanism underlying the treatment effect. Three elements of clinical significance will be addressed: 1) the effects on disability outcomes (physical function domain of M0S-36, proportion achieving community ambulation, reduction of recurrent falls, instrumental activities of daily living, physical and social role domains of M0S-36 and self-reported improvement); 2) the influence of potential modifiers of treatment effects (depression, social support, self-efficacy, and co-morbidity) on disability outcomes; and 3) the comparative costs of the intervention and usual care. The three mechanistic factors that will be explored include the effects the interventions have on impairment in disability outcomes, on postural control, and on the biomechanical characteristics of gait. The long-term goal is to design effective exercise interventions to enhance stroke recovery. The study is a randomized clinical trial of a therapist-supervised program of therapeutic exercise delivered at the subject's home. The study will recruit 180 adults, aged 50 years and older, who are 30 to 90 days post-stroke, who are discharged to the community from acute rehabilitative services, and who meet the criteria for mild to moderate stroke. After screening and baseline assessment, participants will be randomly assigned to a usual-care control group or to the group receiving therapeutic exercises three times a week. The primary outcome measures will be those taken immediately post-intervention, with long-term treatment effects assessed at six months after the intervention.

描述：此OAIC的主要重点是进行旨在的IDSS 改善从中恢复过的老年美国人的功能和独立性 中风。该项目的主要目标是确定生理上是否 基于12周的治疗锻炼计划，该计划针对上和下部 肢体强度，平衡，耐力和上肢使用可以改善 关键障碍和功能性能（运动功能，平衡， 耐力，步态和上肢功能） 中风。次要目标是确定 干预并检查治疗效果的基础机制。三 将解决具有临床意义的要素：1）对 残疾结果（M0S-36的身体功能域，比例实现 社区流动，减少反复跌倒，工具活动 M0S-36和自我报告的日常生活，身体和社会角色领域 改进）; 2）潜在的治疗效果修饰符的影响 （抑郁，社会支持，自我效能和合并症）关于残疾 结果； 3）干预和通常护理的比较成本。 将要探索的三个机械因素包括效果 干预措施对残疾结果的损害，姿势控制， 以及步态的生物力学特征。长期目标是 设计有效的运动干预措施以增强中风恢复。 该研究是一项随机临床试验 在受试者的家中进行的治疗运动。该研究将招募 180名成年人，年龄在50岁及以上的成年人，中风后30至90天，谁 从急性康复服务中解雇给社区，谁 符合轻度至中度中风的标准。筛选和基线后 评估，参与者将被随机分配给通常的护理控制 每周三次接受治疗运动的小组或进行治疗练习。这 主要结果指标将是干预后立即采取的措施， 长期治疗效果在六个月后评估 干涉。