Locomotor Experience Applied Post-Stroke (LEAPS)

中风后应用运动体验 (LEAPS)

• 批准号: 7681296
• 负责人: Pamela W. Duncan
• 金额: $ 228.15万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-25 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7681296
• 关键词: Acute; Adopted; Adult; Affect; Aftercare; Age; Biomechanics; Body Weight; Cardiovascular system; Chronic; Chronic Phase; Clinical Research; Clinical Trials; Clinical Trials Design; Communities; Control Groups; Development; Educational Intervention; Effectiveness of Interventions; Equilibrium; Exercise; Foundations; Frequencies; Funding; Gait; Goals; Grant; Hip Fractures; Home environment; Impairment; Incidence; Individual; Intervention; Life; Locomotor Recovery; Measures; Modality; Monitor; Motor; Outcome; Outcome Measure; Participant; Patient Self-Report; Patients; Persons; Phase; Publishing; Quality of life; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Recovery; Recruitment Activity; Rehabilitation Research; Rehabilitation therapy; Reporting; Research Personnel; Residual state; Risk; Screening procedure; Severities; Site; Speed; Stroke; Structure; Support System; Survivors; Testing; Therapeutic; Time; Training; Training Programs; Treatment Efficacy; Walkers; Walking; Weight; clinical practice; clinical research site; clinically relevant; clinically significant; cost effectiveness; depression; design; disability; experience; falls; improved; indexing; neuroregulation; post stroke; primary outcome; programs; response; skills; stroke rehabilitation; success

DESCRIPTION (provided by applicant): Locomotor training using body weight support and a treadmill as a therapeutic modality for the rehabilitation of walking post-stroke is being rapidly adopted into clinical practice. A recent Cohrane review highlighted the urgent need for a well-designed trial to determine the effectiveness of this intervention. The proposed objective of the Locomotor Experience Applied Post-Stroke (LEAPS) trial is to conduct a 5 year, phase-Ill, single-blind, multi-site (5 clinical sites) randomized clinical trial (RCT) to assess if there is a difference in the proportion of subjects who successfully recover walking ability between a specialized locomotor training program (LTP) that includes use of body weight support and a treadmill as a rehabilitation modality provided 2 months post-stroke (LTP-early) or 6 months post-stroke (LTP-late) and a non-specific, low intensity exercise (control) intervention. The study is designed to be a definitive RCT with the primary outcome being successful recovery of walking (achieving a 0.4 m/s gait speed or greater for persons with initial severe gait impairment (< 0.4 m/s) or as having achieved a 0.8 m/s gait speed or greater for persons with initial moderate gait impairment (> 0.4 m/s - < 0.8 m/s) at 1 year post-stroke. We will also determine if the timing of LTP delivery (early vs. late) affects the improvement in gait speed at 1 year and whether initial locomotor impairment severity interacts with the timing of LTP delivery. The LTP and control interventions will be delivered for 36 sessions over 12 weeks. We will recruit 400 adults, age 18 or older, within 30 days poststroke onset with moderate to severe walking ability. After screening and baseline assessment, subjects will be stratified by baseline locomotor impairment severity as determined by overground walking speed and randomly assigned to 1 of 3 groups: (a) LTP-Early; (b) LTP-Late or (c) Control. The effect of number of treatment sessions will be determined by changes in gait speed taken pre-treatment, post-12, post-24, and post-36 sessions. Our ultimate goal is to provide evidence to guide post-stroke rehabilitation practice and reduce disability in persons post-stroke.

描述（由申请人提供）：使用体重支撑和跑步机作为治疗方式的运动训练，用于恢复后，卒中后恢复行走的方式正在迅速采用临床实践。最近的Cohrane评论强调了迫切需要进行精心设计的试验来确定这种干预的有效性。运动后的运动经验的提议目标是进行5年的5年，相，单盲，多站点（5个临床站点）随机临床试验（RCT），以评估受试者的比例是否有差异，这些受试者的比例是否有差异，这些受试者的比例是否在2个月之间恢复了一个专业运动训练（LTP）的步行能力（LTP），并使用了一个专业的体重支持（LTP），该模式的使用量（LTP）是一项锻炼的一项锻炼，该主题是否有一定的体重量（LTP），该主题是否有差异。冲程后（LTP）或中风后6个月（LTP-LATE）和非特异性的低强度运动（对照）干预。该研究的目的是确定的RCT，主要结果是成功恢复步行（对于初始严重步态损伤（<0.4 m/s）的人达到0.4 m/s的步态速度或更高，或者达到0.8 m/s步态或更高的步态速度或更高的人，对于初始步态障碍的人来说，该研究的人（> 0.4 m/s-/s-/s s）是否会在1年中<0.8 m/s）。交付（早期与晚期）在1年的步态速度上的改善，最初的运动障碍严重程度与LTP的时间相互作用，而LTP的时间和控制干预措施是否会在12周内交付36周。通过地面步行速度和3组中的1个确定的障碍：（a）LTP - （b）LTP late或（c）控制次数。冲程后。

项目成果

Protocol for the Locomotor Experience Applied Post-stroke (LEAPS) trial: a randomized controlled trial.

• DOI: 10.1186/1471-2377-7-39
• 发表时间: 2007-11-08
• 期刊: BMC neurology
• 影响因子: 2.6
• 作者: Duncan PW;Sullivan KJ;Behrman AL;Azen SP;Wu SS;Nadeau SE;Dobkin BH;Rose DK;Tilson JK;LEAPS Investigative Team
• 通讯作者: LEAPS Investigative Team

The quest for the "Holy Grail" of ischemic stroke cytoprotection: Statins may not be the answer.

寻找缺血性中风细胞保护的“圣杯”：他汀类药物可能不是答案。

• DOI: 10.1212/wnl.0b013e3181c6785c
• 发表时间: 2009
• 期刊: Neurology
• 影响因子: 9.9
• 作者: Goldstein,LarryB;Suarez,JoseI
• 通讯作者: Suarez,JoseI

Association Rule Mining to Examine Predictors for the Outcome of Gait Rehabilitation Programs in Stroke Survivors.

• DOI: 10.1097/phm.0000000000001912
• 发表时间: 2022-06-01
• 期刊: AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
• 影响因子: 3
• 作者: Yen, Sheng-Che;Wang, Xiaofan;Wang, Inga;Corkery, Marie B.;Chui, Kevin K.;Chou, Chun-An
• 通讯作者: Chou, Chun-An

The Interface of Clinical Decision-Making With Study Protocols for Knowledge Translation From a Walking Recovery Trial.

• DOI: 10.1097/npt.0000000000000158
• 发表时间: 2017-01
• 期刊: Journal of neurologic physical therapy : JNPT
• 作者: Hershberg JA;Rose DK;Tilson JK;Brutsch B;Correa A;Gallichio J;McLeod M;Moore C;Wu S;Duncan PW;Behrman AL
• 通讯作者: Behrman AL

Does exercise tolerance testing at 60 days poststroke predict rehabilitation performance?

中风后 60 天的运动耐量测试能否预测康复表现？

• DOI: 10.1016/j.apmr.2013.01.031
• 发表时间: 2013
• 期刊: Archives of physical medicine and rehabilitation
• 影响因子: 4.3
• 作者: Rose,DorianK;Behrman,AndreaL;Nadeau,StephenE;Martin,AnatoleD;Schofield,RichardS;Tilson,JulieK;Cen,StevenY;Lu,Xiaomin;Wu,SamuelS;Azen,Stan;Duncan,PamelaW;LEAPSInvestigativeTeam
• 通讯作者: LEAPSInvestigativeTeam