Wake Forest NeuroNext Clinical Site (WAKENN)

维克森林 NeuroNext 临床站点 (WAKENN)

• 批准号: 10214708
• 负责人: Pamela W. Duncan
• 金额: $ 31万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10214708
• 关键词: Academic Medical Centers; Academy; Adult; Advocacy; African American; Alzheimer' s Disease Core Center; American; American Indians; Baptist Church; Bioinformatics; Capsicum; Catchment Area; Childhood; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical Trials Design; Cohort Studies; Collaborations; Communities; Community Care Networks; Community Health; Community Physician; Computerized Medical Record; Consent; Contracts; County; Data; Data Collection; Data Coordinating Center; East Indian; Enrollment; Ensure; Environment; Epidemiology; Feedback; Funding; Genomics; Geography; Goals; Growth; Health; Health Sciences; Health system; Hispanic Americans; Hispanics; Hospitals; Image; Incentives; Income; Individual; Infrastructure; Institutes; K-Series Research Career Programs; Lead; Leadership; Link; Mentors; Mentorship; Mississippi; Multi-Institutional Clinical Trial; Native Americans; Neurologic; Neurologist; Neurology; Neurosciences; North Carolina; Occupational activity of managing finances; Outcome; Patient Recruitments; Patient-Focused Outcomes; Patients; Performance; Physicians; Population; Primary Health Care; Process; Protocols documentation; Public Health; Registries; Reporting; Reproducibility; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Rivers; Rural; Rural Appalachia; Rural Community; Scientist; Site; Special Population; Specimen; System; Training; Translational Research; Translations; Transportation; Underserved Population; United States; United States National Institutes of Health; Virginia; clinical research site; clinical trial participant; community engagement; data integrity; data management; design; experience; federal poverty level; forest; health equity; innovation; member; mid-career faculty; nervous system disorder; next generation; novel; operation; outreach; outreach program; patient health information; practice-based research network; programs; recruit; retention rate; skills; socioeconomics; sound; translational scientist; voucher

Wake Forest Baptist Health (WFBH) is committed to providing neurology clinical trials to our historically underrepresented and geographically diverse patients across our 6-hospital health system and our 26-county catchment area. Joining the NeuroNEXT network as a clinical site would bring the currently uncovered Southeast Atlantic into the national network and enhance it with our diverse patient mix. Three-quarters of our patients live in rural communities and a substantial proportion are below the federal poverty level. Of note, North Carolina has the largest population of American Indians east of the Mississippi River, and one of the fastest-growing Hispanic populations in the nation. Furthermore, WFBH is one of the few fully integrated academic health systems in the U.S. We bring experience in clinical trials, dedicated leadership, and a successful track record of training the next generation of clinician-scientists in neurology. With a strong commitment of institutional resources from our new CEO/Dean, WFBH has robust research infrastructure that includes our CTSA-funded Clinical and Translational Science Institute (CTSI), Maya Angelou Center for Health Equity, NIA-funded Pepper Older Americans Independence and Alzheimer’s Disease Core Centers, and an outstanding Division of Public Health Sciences with extensive experience with multi-site clinical trials and working with NIH coordinating centers. WFBH is also dedicated to training a diverse next generation of neuroscience investigators. WFBH has received 12 Neuroscience K awards in the last 5 years and Neurology is an institutional leader in clinical trial revenues (17.5% of non-NIH income received by WFBH). With these multiple strengths, we will contribute meaningfully to the NeuroNEXT network by carrying out these Specific Aims: AIM 1: To leverage our geographically, ethnically, and economically diverse catchment area to effectively enroll and retain clinical trial participants from historically underserved populations. This includes western North Carolina and southern Virginia, rural Appalachia, and large urban, Hispanic, and African American populations. AIM 2: To engage our patient community in the research process, leveraging our current stakeholder outreach infrastructure to promote NeuroNEXT trials. AIM 3: To leverage the resources of our integrated academic medical center to incentivize, coordinate, and transparently track clinical trial creation, growth, and implementation. AIM 4: To recruit and train the next generation of neurology researchers to design and implement meaningful and reproducible clinical trials. Our experienced co-PIs, Drs. Brashear and Duncan, together with the entire WFBH research leadership, are enthusiastic in offering to the NeuroNEXT network our unique patient mix, strong investigative group, robust research environment for neurology clinical trials, efficient regulatory and contract execution teams, and expertise in conducting efficient and reproducible trials of promising therapies for neurologic disorders.

Wake Forest Baptist Health（WFBH）致力于在我们的6院卫生系统和我们26县的集水区中为我们历史上代表性不足和地理上多样的患者提供神经病学临床试验。加入Neuronext网络作为临床站点，将将目前未发现的东南大西洋带入国家网络，并通过我们的潜水员患者组合来增强它。我们四分之三的患者生活在农村社区，很大一部分居住在联邦贫困水平以下。值得注意的是，北卡罗来纳州是密西西比河以东的美洲印第安人人口最多，也是美国增长最快的西班牙裔人口之一。此外，WFBH是美国为数不多的全面综合学术卫生系统之一，我们带来了临床试验，专门领导力以及成功培训下一代神经学临床科学家的成功记录。 WFBH凭借我们新任首席执行官/院长的机构资源的坚定承诺，具有强大的研究基础设施，其中包括我们的CTSA资助的临床和转化科学研究所（CTSI）（CTSI），Maya Angelou健康公平中心，NIA资助的Pepper Pepper Elderans Indepential和Arzheimer Disease Science的NIA资助的Pepper Science和Alzheimer Science Sciences science science science science sciences science sciences sci ci， NIH协调中心。 WFBH还致力于培训潜水员的下一代神经科学研究者。在过去的5年中，WFBH已获得12项神经科学K奖，而神经病学是临床试验的机构领导者揭示（WFBH获得的非NIH收入的17.5％）。有了这些多种优势，我们将通过执行这些特定目标来为Neuronext网络做出有意义的贡献：目标1：利用我们的地理位置，种族和经济上不同的集水区域，以有效地入学并保留来自历史悠久的人群中的临床试验参与者。其中包括北卡罗来纳州西部和南弗吉尼亚州，粗糙的阿巴拉契亚以及大型城市，西班牙裔和非裔美国人人口。目标2：吸引我们的患者社区参与研究过程，利用我们当前的利益相关者外展基础设施来促进神经元素网络试验。目标3：利用我们综合学术医学中心的资源激励，协调和透明地跟踪临床试验创建，成长和实施。目标4：招募和培训下一代神经病学研究人员，以设计和实施有意义且可重复的临床试验。我们经验丰富的共同案例，博士。 Brashear和Duncan以及整个WFBH研究领导者都热情地提供神经网络网络，我们独特的患者组合，强大的调查小组，针对神经病学临床试验的强大研究环境，有效的监管和合同执行团队以及对神经系统疾病的有效治疗方法进行有效和可重复的试验的专家。