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BLADDER OUTLET OBSTRUCTION INDUCED NEUROPLASTICITY

BLADDER OUTLET OBSTRUCTION INDUCED NEUROPLASTICITY
膀胱出口梗阻引起的神经可塑性
批准号:
6650206
负责人:
Peter Zvara
金额:
$9.96万
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-08-15 至 2004-07-31

项目摘要

项目成果

Peter Zvara的其他基金

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中文摘要
翻译
描述(由申请人提供)良性前列腺增生(BPH)是一种恶性肿瘤
英文摘要
DESCRIPTION (provided by applicant) Benign prostatic hyperplasia (BPH) is the most common cause of bladder outflow obstruction (BOO). This condition is commonly associated with uninhibited urinary bladder contractions. Irritative voiding symptoms, a consequence of uninhibited bladder contractions are very bothersome to a large population of aging men, adversely affecting their quality of life. The overall hypothesis for this research proposal is that the marked changes in the neural control of voiding function that occur following BPH are mediated by multiple factors, including: (1) changes in the properties of urinary bladder afferent neurons induced by peripheral organ (bladder) dysfunction and (2) changes in the properties of interneuronal populations in the spinal cord. Thus, we propose that reorganization of spinal micturition circuitry occurs in response to changes in neural-target organ interactions. We plan to examine the effects of BOO on the neurochemical, organizational and morphological properties of afferent and spinal neurons involved in the micturition reflex pathway. This research proposal aims to provide a more thorough understanding of the wiring diagram for lower urinary tract reflexes and the functions of neurotransmitters in these reflexes. In the first part of our study we will assess neurochemical changes in neurons involved in the micturition reflex that project to the periphery following BOO. Peripheral and spinal neurons projecting to the bladder will be identified following injection of the tracer into the urinary bladder. Subsequently, immunohistochemical techniques will be used to determine changes in the expression of neuroactive compounds in these neurons. A second group of experiments will use pharmacological techniques to evaluate the role of neuroactive compounds in the central micturition pathway following chronic BOO. The effect of selective inhibitors of these neuroactive compounds on the micturition reflexes following BOO and in sham-operated controls will be determined with the use of the cystometrography (recording pressure changes in the urinary bladder during filling and micturition). In the third part of this research project, we propose to determine the organization of urinary bladder interneurons and parasympathetic preganglionic neurons in the. lumbosacral spinal cord. Changes in connectivity between the various spinal elements will be assessed following BOO.
期刊论文(2)
专著(0)
科研奖励(0)
会议论文
Increased expression of neuronal nitric oxide synthase in bladder afferent cells in the lumbosacral dorsal root ganglia after chronic bladder outflow obstruction.
慢性膀胱流出道梗阻后腰骶背根神经节膀胱传入细胞中神经元一氧化氮合酶的表达增加。
DOI: 10.1016/j.brainres.2003.12.016
发表时间: 2004
期刊: Brain research.
影响因子: --
作者: [Zvara,Peter, Folsom,JeffreyB, KlimentJr,Jan, Dattilio,AbbeyL, Moravcikova,Adriana, Plante,MarkK, Vizzard,MargaretA]
通讯作者: Vizzard,MargaretA
Differential expression of bladder neurotrophic factor mRNA in male and female rats after bladder outflow obstruction.
膀胱流出道梗阻后雄性和雌性大鼠膀胱神经营养因子 mRNA 的差异表达
DOI: 10.1016/s0022-5347(05)64244-9
发表时间: 2002
期刊: The Journal of urology
影响因子: --
作者: [Zvara,Peter, KlimentJr,Jan, DeRoss,AnthonyL, Irwin,BrianH, Malley,SusanE, Plante,MarkK, Vizzard,MargaretA]
通讯作者: Vizzard,MargaretA
The Role of TRPV3 Ion Channel in Bladder Function and Sensory Signaling
The Role of TRPV3 Ion Channel in Bladder Function and Sensory Signaling
Correlation of Urinary Bladder Afferent Activity and Function in Awake Mice
Correlation of Urinary Bladder Afferent Activity and Function in Awake Mice
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