A VISUAL CUE MODEL TO INVESTIGATE COCAINE REWARD

研究可卡因奖励的视觉提示模型

• 批准号: 6515327
• 负责人: Chana K. Akins
• 金额: $ 11.11万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515327
• 关键词: brain mapping; cocaine; craving; cues; dopamine; drug abuse; neurochemistry; psychopharmacology; quail; reinforcer; substance abuse related behavior; visual stimulus

DESCRIPTION: (Provided by Applicant) Candidate: Chana K. Akins, Ph.D., is an Assistant Professor in the Department of Psychology at the University of Kentucky. She has served in a tenure-track faculty position for 5 years, during which time she has had 10 publications, and has been awarded two small NSF Minority Planning grants and an NIH Minority Investigator Supplement. Her primary focus has involved studying learning in the sexual behavior system. Her immediate goals are to shift her research focus from animal learning to psychopharmacology and behavioral neuroscience. She would like to improve her knowledge base and acquire mentored-training and experience in these areas to enable her to accomplish her long term goals of developing an independent high-quality research program in psychopharmacology and neuroscience, and of securing independent extramural funding. This application will help her to accomplish those goals. Research: Distal cues that elicit approach to drugs are often visual cues. In humans, these visual cues can elicit the cocaine-related conditioned responses that induce craving. To date, there is no animal model of cocaine reward that is used to focus specifically on the role of visual cues in drug-seeking behavior. Although rodent models have been widely used to study drug reward, because of the limited visual capacity of this species, they may not serve as adequate subjects for examining the relationship between visual cues and drug reward. In addition, although primates have a well-developed visual capacity, they do not lend themselves well to invasive neurochemical and neurobiological techniques. Therefore, this application proposes to use an avian species to conduct behavioral studies to assess the role of visual cues on drug reward, psychopharmacological studies to assess the role of dopamine in cocaine reward, neurochemical studies to localize dopamine systems in the avian brain. Environment: The candidate's sponsoring institution, the University of Kentucky, provides laboratory equipment, space, and access to faculty and staff in order for Dr. Akins to successfully accomplish the goals of the application. In addition, the University of Kentucky Medical Center provides a large number of members of the Society for Neuroscience and consists of a local NIDA (Neuroscientists Interested in Drug Abuse) group. In addition, Dr. Akins will benefit from courses in pharmacology and neuroscience that the University offers. The department and sponsoring institution are committed and fully supportive of releasing Dr. Akins from other duties so that she can devote the required percentage of time for the development of a research career.

描述：（申请人提供） 候选人：查纳K. Akins博士，是系里的助理教授 他是肯塔基州大学心理学教授。她曾在一个终身教职的职位上工作 教师职位5年，在此期间，她有10个出版物， 并已获得两个小NSF少数民族规划赠款和一个NIH少数民族 研究者补充。她的主要重点是研究学习， 性行为系统。她的近期目标是将她的研究重点 从动物学习到精神药理学和行为神经科学。她 我想提高她的知识基础，并获得指导培训， 在这些领域的经验，使她能够实现她的长期目标， 在精神药理学方面发展独立的高质量研究项目 和神经科学，以及获得独立的校外资金。这 应用程序将帮助她实现这些目标。 研究：引起接近药物的远端线索通常是视觉线索。在 人类，这些视觉线索可以引起可卡因相关的条件反射， 会让人产生渴望到目前为止，还没有可卡因奖励的动物模型， 用于专门关注视觉线索在寻找毒品中的作用 行为尽管啮齿动物模型已被广泛用于研究药物奖赏， 由于该物种的视觉能力有限，它们可能无法作为 检查视觉线索与药物之间关系的足够受试者 奖励此外，虽然灵长类动物有发达的视觉能力， 它们不适合于侵入性神经化学和神经生物学 技术.因此，本申请提出使用禽类物种来 进行行为研究，以评估视觉线索对药物奖励的作用， 精神药理学研究来评估多巴胺在可卡因奖赏中的作用， 神经化学研究来定位鸟类大脑中的多巴胺系统。 环境：候选人的赞助机构， 肯塔基州，提供实验室设备，空间，并获得教职员工 为了让阿金斯博士成功实现申请的目标。 此外，肯塔基州大学医学中心提供了大量 由神经科学学会成员组成，并由当地NIDA （对药物滥用感兴趣的神经科学家）此外，艾金斯博士将 受益于药理学和神经科学课程， 的提供.本署及赞助院校致力及 支持释放博士阿金斯从其他职责，使她能够致力于 研究职业发展所需的时间百分比。