Neurobehavioral Correlates of Craniosynostosis

颅缝早闭的神经行为相关性

• 批准号: 6606145
• 负责人: MATTHEW Louis SPELTZ
• 金额: $ 84.83万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6606145
• 关键词: age difference; brain; child behavior; child psychology; clinical research; cognition; compression; computed axial tomography; craniosynostosis; emotional adjustment; gene mutation; genetic screening; human subject; mathematical model; memory; model design /development; neuropsychological tests; neuropsychology; orthopedics; parent offspring interaction; parents; pathologic process; preschool child (1-5); prognosis; psychomotor function

In this multi-site, 5-year longitudinal study, infants with one of four types of single-suture craniosynostosis will be recruited: sagittal, metopic, right unilateral coronal, and left unilateral coronal (n=258). A case-matched "control" group of healthy, normal infants (n=285) will also be followed. The long-term objectives are to chart the neurobehavioral course of single-suture fusions and to better understand how the developing cranium affects human brain growth and function. Specific aims are to: (1) Clarify the neurobehavioral development and parental adjustment of infants with and without single-suture fusions at three time points in infancy and early childhood (just prior to cranioplastic surgery and twice post-surgery, at 18 and 36 months of age); (2) Among children with craniosynostosis, clarify relations between neurobehavioral development and abnormality in bone and brain tissue as indicated by measures taken pre-surgery CT scans; (3) Among children with unicoronal synostosis, clarify relations between neurobehavioral development and presence of genetic mutations; (4) Develop predictive models of 36-month outcomes for infants with craniosynostosis; and (5) Determine the relation between age of cranioplastic surgery and pre- and post- surgery neurobehavioral development. This research will take place in medical centers located in Seattle, Chicago, St. Louis and Atlanta. Seattle's Children's Hospital and Regional Medical Center is the lead agency.

在这项为期5年的多点纵向研究中，有四种类型的单缝合骨融合的婴儿将被纳入研究对象：矢状缝、后缝、右冠和左冠(n=258)。另一组为健康、正常的婴儿(n=285)，与病例相匹配的“对照组”。长期目标是绘制单缝融合的神经行为过程图，并更好地了解发育中的颅骨如何影响人类大脑的生长和功能。具体目的是：(1)阐明在婴幼儿和儿童早期的三个时间点(就在颅骨成形术前和术后两次，18和36个月时)进行单线融合的婴儿的神经行为发育和父母的适应；(2)在颅缝融合的儿童中，阐明神经行为发育与手术前CT扫描所显示的骨和脑组织异常之间的关系；(3)在单冠融合的儿童中，澄清神经行为发育与基因突变的存在之间的关系；(4)建立颅缝融合婴儿36个月预后的预测模型；(5)确定颅骨整形手术患者年龄与手术前后神经行为发育的关系。这项研究将在西雅图、芝加哥、圣路易斯和亚特兰大的医疗中心进行。西雅图儿童医院和地区医疗中心是牵头机构。