Neurobehavioral Correlates of Craniosynostosis

在这项为期5年的多部位纵向研究中，将招募四种类型的单缝合线颅缝闭塞的婴儿：矢状面、异位面、右侧单侧冠状面和左侧单侧冠状面（n=258）。一个病例匹配的健康正常婴儿“对照”组（n=285）也将被跟踪。长期目标是绘制单缝线融合的神经行为过程，并更好地了解发育中的头盖骨如何影响人类大脑的生长和功能。具体目的是：(1)明确在婴儿期和幼儿期的三个时间点（颅整形手术前和术后两次，18个月和36个月）进行单缝线融合和不进行单缝线融合的婴儿的神经行为发育和父母适应；(2)在颅缝闭闭患儿中，通过术前CT扫描，明确神经行为发育与骨脑组织异常的关系；(3)在单冠状关节闭锁患儿中，明确神经行为发育与基因突变的关系；(4)建立颅缝闭合婴儿36个月预后预测模型；(5)确定颅骨整形手术年龄与手术前后神经行为发育的关系。这项研究将在西雅图、芝加哥、圣路易斯和亚特兰大的医疗中心进行。西雅图儿童医院和地区医疗中心是牵头机构。

In this multi-site, 5-year longitudinal study, infants with one of four types of single-suture craniosynostosis will be recruited: sagittal, metopic, right unilateral coronal, and left unilateral coronal (n=258). A case-matched "control" group of healthy, normal infants (n=285) will also be followed. The long-term objectives are to chart the neurobehavioral course of single-suture fusions and to better understand how the developing cranium affects human brain growth and function. Specific aims are to: (1) Clarify the neurobehavioral development and parental adjustment of infants with and without single-suture fusions at three time points in infancy and early childhood (just prior to cranioplastic surgery and twice post-surgery, at 18 and 36 months of age); (2) Among children with craniosynostosis, clarify relations between neurobehavioral development and abnormality in bone and brain tissue as indicated by measures taken pre-surgery CT scans; (3) Among children with unicoronal synostosis, clarify relations between neurobehavioral development and presence of genetic mutations; (4) Develop predictive models of 36-month outcomes for infants with craniosynostosis; and (5) Determine the relation between age of cranioplastic surgery and pre- and post- surgery neurobehavioral development. This research will take place in medical centers located in Seattle, Chicago, St. Louis and Atlanta. Seattle's Children's Hospital and Regional Medical Center is the lead agency.