Neurobehavioral Correlates of Craniosynostosis

颅缝早闭的神经行为相关性

• 批准号: 6606145
• 负责人: MATTHEW Louis SPELTZ
• 金额: $ 84.83万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6606145
• 关键词: age difference; brain; child behavior; child psychology; clinical research; cognition; compression; computed axial tomography; craniosynostosis; emotional adjustment; gene mutation; genetic screening; human subject; mathematical model; memory; model design /development; neuropsychological tests; neuropsychology; orthopedics; parent offspring interaction; parents; pathologic process; preschool child (1-5); prognosis; psychomotor function

In this multi-site, 5-year longitudinal study, infants with one of four types of single-suture craniosynostosis will be recruited: sagittal, metopic, right unilateral coronal, and left unilateral coronal (n=258). A case-matched "control" group of healthy, normal infants (n=285) will also be followed. The long-term objectives are to chart the neurobehavioral course of single-suture fusions and to better understand how the developing cranium affects human brain growth and function. Specific aims are to: (1) Clarify the neurobehavioral development and parental adjustment of infants with and without single-suture fusions at three time points in infancy and early childhood (just prior to cranioplastic surgery and twice post-surgery, at 18 and 36 months of age); (2) Among children with craniosynostosis, clarify relations between neurobehavioral development and abnormality in bone and brain tissue as indicated by measures taken pre-surgery CT scans; (3) Among children with unicoronal synostosis, clarify relations between neurobehavioral development and presence of genetic mutations; (4) Develop predictive models of 36-month outcomes for infants with craniosynostosis; and (5) Determine the relation between age of cranioplastic surgery and pre- and post- surgery neurobehavioral development. This research will take place in medical centers located in Seattle, Chicago, St. Louis and Atlanta. Seattle's Children's Hospital and Regional Medical Center is the lead agency.

在这项为期 5 年的多地点纵向研究中，将招募患有四种类型单缝颅缝早闭之一的婴儿：矢状型、同位型、右单侧冠状型和左单侧冠状型（n=258）。 还将对病例匹配的健康、正常婴儿（n=285）“对照”组进行跟踪。 长期目标是绘制单缝融合的神经行为过程，并更好地了解发育中的颅骨如何影响人类大脑的生长和功能。 具体目标是： (1) 阐明有或没有单缝融合的婴儿在婴儿期和幼儿期三个时间点（颅骨整形手术之前和手术后两次，18 个月和 36 个月时）的神经行为发育和父母调整； (2) 对于颅缝早闭患儿，根据术前CT扫描采取的措施，明确神经行为发育与骨和脑组织异常之间的关系； (3) 在单冠骨联的儿童中，阐明神经行为发育与基因突变存在之间的关系； (4) 开发颅缝早闭婴儿36个月结局的预测模型； (5)确定颅骨整形手术年龄与手术前后神经行为发育之间的关系。这项研究将在西雅图、芝加哥、圣路易斯和亚特兰大的医疗中心进行。 西雅图儿童医院和地区医疗中心是牵头机构。